Electrical Impedance Spectroscopy and Imaging

电阻抗光谱和成像

• 批准号: 6232719
• 负责人: ALEXANDER HARTOV
• 金额: $ 18.71万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6232719
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; breast neoplasms; clinical research; diagnosis design /evaluation; digital imaging; early diagnosis; female; human subject; human tissue; image enhancement; mammography; neoplastic process; spectrometry; women's health

While X-ray mammography has proven to be a highly sensitive clinical tool which is likely to remain as the primary method of screening for breast cancer, there is room for some significant advances in the type of information that can be presented to the clinical mammographer. Project II hypothesizes that electrical impedance spectroscopy (EIS) imaging can become a valuable clinical technique for detecting and diagnosis breast cancer by providing complementary information to that of x-ray mammography. Data in the literature has repeatedly shown that there is not only significant inherent contrast in the electrical impedance of normal and cancerous breast tissue but also that there is not only significant inherent contrast in the electrical impedance of normal and cancerous breast tissue but also that spectroscopic data can provide information on the functional status of breast tissue that could be used to diagnose benign from malignant abnormalities. Hence, while EIS may be low in overall structural imaging resolution, the high soft tissue contrast and dispersion in the electrical impedance signatures of normal and pathological tissues make a compelling argument for the potential value of EIS in terms characterizing the functional status of the imaged tissue volume through the spatially-resolved spectroscopic information that would be provided-information that is not readily available through other imaging modalities. The specific aims of Project II can be summarized as (1) to develop a multi-channel (up to 128), multi-frequency (10KHs to 5MHz), dual mode (applied current or voltage) data acquisition system and concomitant clinical electrode interface to the breast which facilitates a safe, comfortable, efficiently administered patient examine while optimizing EIS imaging performance, (2) in conjunction with the Computational ore, to develop two and three dimensional EIS image reconstruction capabilities which exploit advanced model-based image reconstruction concepts such as adaptive dual meshing, multi-component objective function minimization, parallel processing, and multi-spectral imaging, (3) to evaluate and optimize EIS imaging system performance in preclinical processing, and multis-spectral imaging, (3) to evaluate and optimize EIS imaging system performance in preclinical studies involving tissue-equivalent phantoms having geometries relevant to breast tissue imaging and (4) in collaboration with the Clinical Core, to not only demonstrate the feasibility of administering EIS breast imaging exams on human subjects but also to initiate an evaluation of the efficacy of EIS breast imaging as a diagnostic tool by correlating results with patients having normal and abnormal mammograms. The work proposed represents a unique synthesis of existing and novel ideas which should lead to important new information/documentation concerning the potential value of EIS in breast cancer detection. Not only is the scientific rationale for pursuing EIS breast imaging strong, but the practical features of (i) ease of use, (ii) low-cost and (iii) non-ionizing interrogation also make the approach extremely attractive.

尽管事实证明，X射线乳房X线摄影是一种高度敏感的临床工具，可能仍然是筛查乳腺癌的主要方法，但可以向临床乳房X线摄影师介绍的信息类型有一些重大进展。项目II假设电阻抗光谱（EIS）成像可以通过提供X射线乳房X线摄影的互补信息来成为检测和诊断乳腺癌的宝贵临床技术。文献中的数据反复表明，正常乳腺组织和癌性乳腺组织的电阻抗不仅存在明显的固有对比度，而且不仅在正常和癌性乳腺组织的电阻抗中存在明显的固有对比度，而且光谱数据还可以提供有关可用于诊断出良性良性良性Abnormal normal normal Abnormal normal normals orignal normal normal normal Abnormal somanal normal normal Abnormal normal Abnormal normal Abnormans Abnormans Abnormans Abnormans normal normal normal normal normal normal的乳腺组织状态的信息。因此，虽然EIS的总体结构成像分辨率可能低，但正常和病理组织的电阻抗特征的高软组织对比度和分散性使EIS在表征EIS的潜在价值的术语中具有令人信服的论据，表征了通过空间分辨的光谱谱信息可用来提供的，这些术语表征了成像组织体积的功能状态，这些信息无法通过其他信息提供其他图像。 The specific aims of Project II can be summarized as (1) to develop a multi-channel (up to 128), multi-frequency (10KHs to 5MHz), dual mode (applied current or voltage) data acquisition system and concomitant clinical electrode interface to the breast which facilitates a safe, comfortable, efficiently administered patient examine while optimizing EIS imaging performance, (2) in conjunction with the计算矿石，开发两个和三维的EIS图像重建功能，这些功能可以利用基于先进的模型的图像重建概念，例如自适应双重网格，多组分目标函数最小化，并行处理，并平行处理以及多光谱图像，（3）评估和优化EIS Imibize系统的性能，以评估和优化EIS Imibize Semptrize Esimal Image tremprime tempemtral Imaging Imaging Imaging，（3）临床前研究的表现涉及与乳腺组织成像相关的几何形状以及（4）与临床核心合作的几何形状的表现，不仅可以证明对人类受试者进行EIS乳房成像检查的可行性，还可以通过诊断患者的诊断和abnsgragment and-abnsgragn和Absongragmins ands norkal ands abless norking and to norky hore乳房成像的功效。提出的工作代表了现有和新颖思想的独特综合，应导致有关EIS在乳腺癌检测中潜在价值的重要新信息/文档。追求EIS乳房成像的科学原理不仅是（i）易用性的实际特征，（ii）低成本和（iii）非电源审讯也使该方法非常有吸引力。