Analytic Core C

分析核心C

基本信息

批准号：
9532076
负责人：
Enrique Cadenas
金额：
$ 37.28万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-08-15 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9532076
关键词：
Alleles Alzheimer&apos s Disease Alzheimer&apos s disease risk Animals Apolipoprotein E Archives Bioenergetics Bioinformatics Biological Biological Markers Blood specimen Brain Brain Diseases Clinical Clinical Data Complementary DNA Custom Data Analyses Databases Development Disease Early identification Estradiol Expression Profiling Freezing Gene Expression Profile Gene Expression Profiling Gene Targeting Generic Drugs Genes Genetic Genotype Goals Human Inflammatory Intervention Lead Link Literature Longevity Menopause Metabolic Mission Pathology Pathway Analysis Pathway interactions Perimenopause Phenotype Play Population Postmenopause Primary Cell Cultures Principal Component Analysis Progesterone Protein Isoforms Proteins RNA Regimen Regulation Research Research Infrastructure Resources Risk Rodent Role Sampling Standardization Steroids System Systems Biology Technology Tissue Sample Translating Woman aging brain analytical method apolipoprotein E-4 base brain metabolism brain tissue cognitive function data integration data management density endophenotype functional group lipid metabolism neuroimaging prevent programs steroid hormone tissue processing tool

项目摘要

PROJECT SUMMARY-ANALYTIC CORE C The mission of our Perimenopause in Brain Aging and Alzheimer's Disease Program Project (P3) is to discover biological transformations in brain that occur during the perimenopausal transition that lead to endophenotypes predictive of risk for Alzheimer's disease (AD). Our goals are to identify the mechanisms by which these transformations occur and to translate these discoveries into strategies to prevent conversion to an at-Alzheimer's-risk phenotype. To achieve our Perimenopausal Program Project mission, we have developed a set of integrated program-wide specific aims that span mechanistic discovery to clinical neuroimaging in ApoE genotyped perimenopausal and postmenopausal women to a global population through the ENIGMA network of neuroimages, clinical data and ApoE genetics. The mission of Analytic Core is to provide standardized steroid hormone regimens, sample archiving, processing and distribution, as well as analytic support across the Perimenopausal Program Project. The mission of Analytic Core is to provide standardized steroid hormone regimens, sample archiving, processing and distribution, as well as analytic support across the Program Project. To achieve this mission, the Analytic Core will provide two levels of support. The first level of support entails standardized steroid hormone regimens and sample management. The second level of support entails sample analysis and data interpretation on four major studies: LC-MS/MS steroid analysis, ApoE genotyping, custom array gene expression analysis, and bioinformatic gene functional analysis. Analytic Core was an instrumental and essential resource for the previous Progesterone Program Project and the currently ongoing Perimenopause Program Project. Through the infrastructure and analytic methods it has developed, Analytic Core will continue to play a crucial role in achieving the renewed Perimenopausal Program Project's mission and aims.

项目概要-分析核心 C 我们的围绝经期脑衰老和阿尔茨海默病计划项目 (P3) 的使命是发现围绝经期过渡期间大脑中发生的生物转变，从而导致内表型可预测阿尔茨海默病 (AD) 的风险。我们的目标是确定机制这些转变的发生以及将这些发现转化为预防策略转化为阿尔茨海默病风险表型。为了实现我们的围绝经期计划项目的使命，我们制定了一套综合计划范围内的具体目标，涵盖机械发现到全球 ApoE 基因分型围绝经期和绝经后女性的临床神经影像学通过神经图像、临床数据和 ApoE 遗传学的 ENIGMA 网络对人群进行分析。的使命分析核心是提供标准化的类固醇激素治疗方案、样本存档、处理和分布以及整个围绝经期计划项目的分析支持。的使命分析核心是提供标准化的类固醇激素治疗方案、样本存档、处理和分布以及整个计划项目的分析支持。为了实现这一使命，分析 Core将提供两个级别的支持。第一级支持需要标准化类固醇激素方案和样本管理。第二级支持需要样本分析和数据四项主要研究解读：LC-MS/MS 类固醇分析、ApoE 基因分型、定制芯片基因表达分析、生物信息基因功能分析。分析核心是一个工具性和之前的黄体酮计划项目和当前正在进行的项目的重要资源围绝经期计划项目。通过其开发的基础设施和分析方法， Analytic Core 将继续在实现更新的围绝经期计划中发挥关键作用项目的使命和目标。