2013 Oxidative Stress and Disease Gordon Research Conference & Seminar

2013年氧化应激与疾病戈登研究会议

• 批准号: 8525506
• 负责人: Enrique Cadenas
• 金额: $ 5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-15 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8525506
• 关键词: Address; Age; Alzheimer' s Disease; American; Bioenergetics; Brain; Clinical; Cognition; Cognitive; Collaborations; Communication; Consensus; Development; Diabetes Mellitus; Discipline; Disease; Educational workshop; Energy Metabolism; Environment; Feedback; Fees; Foundations; Funding; Funding Agency; Future Generations; Individual; Inflammation; Inflammatory; Inflammatory Response; Insulin Resistance; International; Intervention; Investigation; Memory Loss; Mentors; Mentorship; Metabolic; Metabolism; Nature; Nerve Degeneration; Neurodegenerative Disorders; Oral; Oxidation-Reduction; Oxidative Stress; Participant; Postdoctoral Fellow; Preventive; Regulation; Request for Applications; Research; Research Personnel; Research Project Grants; Role; Science; Scientist; Solid; Switzerland; Synaptic plasticity; System; Techniques; Therapeutic Intervention; Training; Translations; abstracting; age related neurodegeneration; aging brain; career; career development; design; graduate student; interest; meetings; member; neuroimaging; novel; novel therapeutic intervention; posters; prevent; programs; public health relevance; response; symposium

DESCRIPTION (provided by applicant): The 7th Gordon Research Conference (GRC) on Oxidative Stress and Disease has been assembled around the theme The Metabolic - Inflammatory Axis in Brain Aging and Alzheimer's Disease and is designed from an interdisciplinary perspective to provide discovery, translational, and clinical scientists with the latest findings on the role of oxidative stress in energy metabolism and inflammatory responses in brain aging and neurodegeneration, with emphasis on Alzheimer's disease. The GRCs are internationally recognized for the high-quality and cutting-edge nature of their meetings. The 2013 GRC on Oxidative Stress and Disease, The Metabolic-Inflammatory Axis in Brain Aging and Alzheimer's Disease, will be held on 14-19 April 2013 at the Les Diablerets Conference Center, Switzerland. The scientific program focuses on bioenergetic deficits and activation of inflammatory responses, their redox (oxidative stress) regulation, and their role in synaptic plasticity and cognition in healthy brain aging and Alzheimer's. Dynamic interactions among these systems are examined in terms of their causative or in-tandem occurrence and how does the systemic environment, e.g., insulin resistance, diabetes, and inflammation, impact on brain function. The significance of addressing 'healthy' brain aging and Alzheimer's disease is established by the escalation of Alzheimer's, which currently (2012) impacts more than 5.4 million Americans of all ages, and is projected to rise by 30% by 2025. This 2013 GRC on Oxidative Stress and Disease brings together an international cadre of experts with a broad range of interests and approaches to healthy brain aging and to Alzheimer's disease; this provides a unique forum for in-depth discussions on cellular mechanisms and their forward translation into interventions to prevent, delay, or treat the memory loss and cognitive slowing associated with brain aging and exacerbated in Alzheimer's disease. This GRC is also an example of reverse translation inasmuch as clinical scientists using non-invasive neuroimaging techniques will share their findings with basic scientists. In addition, a Gordon Research Seminar (GRS) will be organized by junior investigators at the post-doctoral level. The GRS will be held the day before the GRC (13 April 2013) and is oriented towards junior investigators and aimed at (a) providing them with solid background on common mechanisms involved in brain aging and neurodegeneration in order to maximize the understanding of the science that will be discussed in the subsequent GRC; (b) promoting communications between young investigators that nurture potential collaborations, and creating a collegial mentorship from senior members for career and academic development. We fully anticipate that the scientific discussions, research talks, poster sessions and other close interactions among the participants of the GRC and the GRS will significantly advance their understanding of the mechanisms inherent in healthy brain aging or its progression into Alzheimer's disease and set the foundations for collaborative investigations aimed at promoting new therapeutic interventions for these disorders.

描述（由申请人提供）：第七届戈登氧化应激和疾病研究会议（GRC）围绕“脑衰老和阿尔茨海默病中的代谢-炎症轴”主题召开，从跨学科的角度设计，旨在提供发现、转化、和临床科学家 关于氧化应激在大脑衰老和神经退行性疾病中能量代谢和炎症反应中的作用的最新发现，重点是阿尔茨海默病。 GRC 因其会议的高质量和前沿性而获得国际认可。 2013 年氧化应激与疾病、大脑衰老和阿尔茨海默病的代谢炎症轴 GRC 将于 2013 年 4 月 14 日至 19 日在瑞士莱迪亚布勒雷会议中心举行。该科学计划的重点是生物能量缺陷和炎症反应的激活、氧化还原（氧化应激）调节，以及它们在突触可塑性和健康大脑衰老和阿尔茨海默病认知中的作用。这些系统之间的动态相互作用根据其因果或串联发生以及全身环境（例如胰岛素抵抗、糖尿病和炎症）如何影响大脑功能进行检查。解决“健康”大脑老化和阿尔茨海默氏病的重要性体现在阿尔茨海默氏病的不断升级，目前（2012 年）阿尔茨海默病影响着超过 540 万各个年龄段的美国人，预计到 2025 年将增加 30%。 2013 年 GRC氧化应激与疾病汇集了一批国际专家，他们对健康大脑老化和阿尔茨海默氏病有着广泛的兴趣和方法；这为深入讨论细胞机制及其向前转化为干预措施提供了一个独特的论坛，以预防、延迟或治疗与大脑衰老和阿尔茨海默病加剧相关的记忆丧失和认知减慢。该 GRC 也是逆向翻译的一个例子，因为使用非侵入性神经影像技术的临床科学家将与基础科学家分享他们的发现。此外，戈登研究研讨会（GRS）将由博士后级别的初级研究人员组织。 GRS 将于 GRC 前一天（2013 年 4 月 13 日）举行，面向初级研究人员，旨在 (a) 为他们提供有关大脑衰老和神经退行性变的常见机制的坚实背景，以便最大限度地理解科学这将在后续的 GRC 中讨论； (b) 促进年轻研究者之间的沟通，培养潜在的合作，并为职业和学术发展建立资深成员的同事指导。我们完全预计，GRC 和 GRS 参与者之间的科学讨论、研究讲座、海报会议和其他密切互动将显着增进他们对健康大脑衰老或其进展为阿尔茨海默病的固有机制的理解，并为以下领域奠定基础：旨在促进这些疾病的新治疗干预措施的合作研究。