Histories of Social Engagement and Cognitive Functioning

社会参与和认知功能的历史

• 批准号: 7653309
• 负责人: Teresa E SEEMAN
• 金额: $ 51.43万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-15 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7653309
• 关键词: Abuse Reporting; Address; Adult; Affect; Age; Attention; Biological; Biology; California; Cessation of life; Child; Childhood; Cognition; Cognitive; Cognitive aging; Conflict (Psychology); Coronary heart disease; Critiques; Data; Data Set; Databases; Dementia; Divorce; Elderly; Emotional; Etiology; Event; Exhibits; Faculty; Family; Fathers; Funding; Future; Goals; Grant; Health; Healthcare; Impaired cognition; Individual; Interdisciplinary Study; Intervention; Investigation; Knowledge; Lead; Life Cycle Stages; Light; Link; Measures; Mental Health; Occupations; Outcome; Parents; Participant; Pattern; Performance; Physiology; Population; Positioning Attribute; Published Comment; Recording of previous events; Relative (related person); Reporting; Research; Research Personnel; Risk; Risk Factors; Role; Sampling; Series; Siblings; Social support; Socioeconomic Status; Subgroup; Testing; Time; Twin Multiple Birth; Validity of Self Report; Variant; Wages; Woman; Work; affection; aged; cardiovascular risk factor; cognitive change; cognitive function; cohort; effective intervention; experience; health disparity; high risk; improved; innovation; member; men; mortality; novel; physical abuse; physical conditioning; public health research; relating to nervous system; response; sex; social; sound; success; therapy design; therapy development

In response to the request for a revised set of Specific Aims, we propose to address the first two aims outlined in our June 2008 submission for R01 AG 032271 ("Social Engagement Histories and Cognition"). These two aims can be completed in a 2-year period and would test significant hypotheses regarding the potentially.. important relationships between patterns of social engagement from childhood through later adulthood and · sUbsequentadultcognition. Results of the proposed analyses will provide needed information on whether and how social relationships influence adult cognition - information that is crucial to our ability to develop effective interventions to reduce risks to cognition. Availability of such interventions will only become more critical as the fraction of the US population aged 65 and older (Le., those at high risk for poor cognition and its associated health care and other financial burdens) continues to grow rapidly in coming decades. ' I n consideration for the wider goals of the ARRA, we also note that the proposed work would fund two positions - one each at UCLA and Brandeis - for data analysts. In each case, these are positions that will be terminated unless this funding is received due to lack of adequate alternative grant support. Funding from this application would also cover portions of salaries for investigators who, although already on faculty at UCLA, " 'are supported solely by research funds so that their positions must be terminated if insufficient funding is available to cover their time (Le., they are not supported by State of California funds). Results of the proposed work hold the potential to create further jobs to the extent that findings lead to further efforts to develop interventions - with both intervention development and subsequent implementation involving new job opportunities. The reviewers were satisfied with the way we had addressed the majority of prior comments. Below, we provide brief responses to the few remaining questions raised by reviewers. Overall, we were gratified that reviewers felt that we were "very responsive to prior critiques", including provision of information "persuasive that the cognitive assessment is a strong measure of cognition", and that ours was a "very strong and innovative resubmission". We were also pleased that reviewers felt our application was "highly innovative", "addresses a significant issue with an innovative and sound approach", "demonstrates how interdisciplinary studies can be integrated in novel and unique ways", and "generates a high degree of enthusiasm",

为了应对对一套修订的特定目标的要求，我们建议解决2008年6月提交R01 AG 032271（“社会参与历史与认知”）中概述的前两个目标。这两个目标可以在2年的时间内完成，并将检验有关潜在的潜在的重要假设。拟议分析的结果将提供有关社会关系是否以及如何影响成人认知的所需信息 - 这对于我们制定有效干预措施以减少认知风险的能力至关重要。这种干预措施的可用性只会变得更加关键，因为美国65岁及65岁及以上的人口的比例（LE，认知不良的风险及其相关的医疗保健和其他金融伯伦斯的风险很高）在未来几十年中继续迅速增长。 ``考虑到ARRA的更广泛目标，我们还指出，拟议的工作将为数据分析师提供两个职位 - 分别在UCLA和Brandeis中提供。在每种情况下，除非由于缺乏足够的替代赠款支持而获得资金，否则这些职位将被终止。该应用程序中的资金还将覆盖调查人员的一部分薪水，尽管他们已经在UCLA的教职员工，但仅受研究资金的支持，以便必须终止其头寸，如果不足的资金可用来支付时间来支付时间（LE。，他们都不是由加利福尼亚州资金提供的范围来实现的。实施涉及新的工作机会。 审稿人对我们处理大多数先前评论的方式感到满意。下面，我们对审阅者提出的剩下的几个问题提供了简短的回答。总体而言，我们对审稿人认为我们“对先前的批判性非常有反应”，包括提供信息，“有说服力的认知评估是认知的强烈衡量”，而我们的人是“非常强大且创新的重新提交”。我们也很高兴审稿人认为我们的应用是“高度创新的”，通过创新和合理的方法解决了一个重大问题，“展示了如何以新颖和独特的方式整合跨学科研究”，并“产生了高度的热情”，“