Testing Intervention Strategies for Addressing Obesity and Binge Eating

测试解决肥胖和暴食问题的干预策略

基本信息

批准号：
9768477
负责人：
Andrea Kass Graham
金额：
$ 14.97万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9768477
关键词：
Address Adult Affect Behavior Disorders Behavior Therapy Behavioral Binge Eating Body Weight Changes Body Weight decreased Clinical Clinical Trials Comorbidity Data Data Analyses Drops Eating Eating Disorders Ensure Environment Food Future Goals Health Health Care Costs Health Services Accessibility Impairment Individual Intervention Medical Mentored Research Scientist Development Award Mentorship Metabolic syndrome Methods Morbidity - disease rate Obesity Outcome Overweight Participant Patients Population Protocols documentation Public Health Quality of life Randomized Recurrence Research Research Personnel Risk Shapes Subgroup Testing Time Training Training Support United States National Institutes of Health Universities Weight Weight Gain Weight maintenance regimen adult obesity base career compliance behavior cost design digital experience follow-up health care quality improved improved outcome intervention effect mortality negative affect novel obesity treatment personalized care personalized intervention pilot trial post intervention preservation programs prototype psychologic psychosocial recruit retention rate self help skills success therapy design trial design usability user centered design weight loss intervention

项目摘要

PROJECT SUMMARY Obesity is a significant public health problem, with medical and psychosocial morbidities, impaired quality of life, increased mortality, and substantial health care costs. Up to 30% of treatment-seeking individuals with obesity have comorbid binge eating, an eating disorder behavior characterized by eating a large amount of food and experiencing loss of control. First-line interventions are face-to-face treatments for obesity or binge eating, but current approaches fail to address both conditions and cannot reach all people in need. To tackle comorbid obesity and binge eating, an intervention needs to be designed that: 1) targets both weight and binge eating; 2) improves the efficiency of the intervention while preserving its potency; and 3) is scalable to large populations of users. Thus, I propose a research agenda to design a mobile intervention that targets obesity and binge eating, which aligns with the NIH’s call for research that enhances the precision of intervention delivery. I will conduct two studies with adults with obesity (BMI ≥30) and recurrent binge eating (≥12 binge episodes in the past 3 months). First, I will employ a user-centered design approach to design a 16- session guided self-help, mobile intervention that combines components of psychological and behavioral weight loss (BWL) interventions. Overvaluation of weight and shape, unhealthy weight control practices, and negative affect are key treatment targets in psychological interventions for binge eating, but are not components of BWL. Thus, I will design an intervention that integrates these three components as adjuncts to BWL. I will conduct usability testing to inform intervention refinements prior to a pilot trial (Aim 1). Second, I will conduct a randomized pilot trial to determine the feasibility of delivering the intervention protocol and to generate preliminary data on the effect of the intervention on changes in weight and binge eating at 16 weeks (post-intervention) and 3 months post-intervention (follow-up) (Aims 2 & 3). I will use a 23 full factorial trial design to randomly assign participants to a combination of the 3 components (n=8 conditions) in order to isolate which of the 3 intervention components are active ingredients. I will apply the Multiphase Optimization Strategy framework to optimize the intervention. These aims support my training plan in which I will receive expert mentorship and training in user-centered design and usability testing (Training Goal 1); using novel frameworks and efficient trial designs (Training Goal 2); and longitudinal data analysis of clinical trials (Training Goal 3). Expertise of the mentorship team, along with the academic and training environment of Northwestern University, will ensure my success. Results of this study will be used to optimize the intervention, which I will then test in a subsequent R01 trial. This K01 Mentored Research Scientist Development Award will equip me with the skills and data to facilitate my career goal of becoming a leader in increasing access to high- quality health care for obesity and weight-related issues, such as binge eating, using scalable interventions.

项目概要肥胖是一个重大的公共卫生问题，会导致医疗和社会心理疾病、生活质量受损高达 30% 的寻求治疗的人患有这种疾病。肥胖症伴有暴食症，这是一种饮食失调行为，其特征是吃大量食物食物和失控的一线干预措施是面对面治疗肥胖或暴饮暴食。但目前的方法无法解决这两种情况，也无法惠及所有有需要的人。肥胖和暴食共存，需要设计一项干预措施：1) 针对体重和暴食饮食；2）提高干预效率，同时保持其效力；3）可大规模扩展；因此，我提出了一个研究议程来设计针对用户群体的移动干预措施。肥胖和暴饮暴食，这符合 NIH 的呼吁，即提高研究的准确性我将对患有肥胖症（BMI ≥30）和经常暴饮暴食的成年人进行两项研究。（过去 3 个月内连续观看 12 集以上）首先，我将采用以用户为中心的设计方法来设计 16-。会议引导的自助、移动干预结合了心理和行为的组成部分减肥（BWL）干预措施对体重和体形的高估、不健康的体重控制做法以及负面情绪是暴食心理干预的关键治疗目标，但并非如此因此，我将设计一种干预措施，将这三个组成部分作为辅助手段进行整合。 BWL。我将在试点之前进行可用性测试，以告知干预措施的改进（目标 1）。进行随机试点试验以确定实施干预方案的可行性并生成有关干预措施对 16 周时体重变化和暴饮暴食影响的初步数据（干预后）和干预后 3 个月（随访）（目标 2 和 3）我将使用 23 项全析因试验。设计将参与者随机分配到 3 个组件的组合（n=8 条件），以便隔离 3 种干预成分中的哪一种是活性成分，我将应用多相优化。这些目标支持我将接受的培训计划。以用户为中心的设计和可用性测试方面的专家指导和培训（培训目标 1）；框架和有效的试验设计（培训目标 2）和临床试验的纵向数据分析；（培训目标 3）。导师团队的专业知识，以及学术和培训环境。西北大学将确保我的研究结果将用于优化干预措施，然后我将在随后的 R01 试验中测试该 K01 指导研究科学家发展奖。为我提供技能和数据，以促进我的职业目标，即成为增加获得高水平机会的领导者使用可扩展的干预措施，针对肥胖和体重相关问题（例如暴饮暴食）提供高质量的医疗保健。