Support for GENESIS

支持创世纪

• 批准号: 7619161
• 负责人: JAMES M BOWER
• 金额: $ 32.47万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7619161
• 关键词: 19 year old; Access to Information; Biological; Biological Models; Book Chapters; Books; Brain; Brazil; Code; Collaborations; Communities; Computer software; Continuing Education; Data; Databases; Development; Education; Educational Curriculum; Educational process of instructing; European Union; Extensible Markup Language; Foundations; Functional disorder; Funding; Grant; Growth; India; Instruction; Internet; Japan; Laboratories; Latin America; Link; Maintenance; Marines; Measures; Medical; Medical Education; Medical Students; Medicine; Methods; Mexico; Modeling; Molecular; Morphology; Nature; Nervous system structure; Neurobiology; Neurons; Online Systems; Pathway interactions; Peer Review; Physicians; Play; Publications; Publishing; Recording of previous events; Reporting; Research; Role; Series; Stream; Structure; Students; Support System; System; Technology; Text; Time; Translational Research; United States National Institutes of Health; Universities; Update; Wood material; base; biological research; clinical Diagnosis; college; computational neuroscience; design; flexibility; journal article; medical schools; meetings; model development; multi-scale modeling; open source; prototype; relating to nervous system; simulation; software development; software systems; tool

DESCRIPTION (provided by applicant): The General Neural Simulation System (GENESIS) was first released for general use in 1988 as part of the first Methods in Computational Neuroscience Meeting at the Marine Biological Laboratory in Woods Hole, MA. Since its original release 19 years ago, GENESIS has provided one of the foundations for the growth of computational neuroscience both continuing to support education as well as research. With respect to summer courses, GENESIS continues to be part of the course in Woods Hole, as well as courses offered in the European Union, Mexico, India, Japan, and recently a new course in Brazil for Latin America. At last count GENESIS has also provided support for courses in at least 61 colleges and universities around the world where it has been used both as an instruction tool in realistic modeling of the nervous system, and as a simulation based tool for neurobiological education in general. The Book of GENESIS (Bower and Beeman, 1994, 1998), which was designed to support both computational and neurobiological instruction has sold more than 6,000 copies worldwide with more than double that number of copies having been distributed with the text now freely available on the Internet (Bower and Beeman, 2003). This substantial support for the use of GENESIS in instruction has also provided the base for extensive and growing use of this software system in biological research. Although certainly an underestimate, we are aware of 297 published GENESIS-dependent peer reviewed journal articles and book chapters not directly related to research in the P.I.'s laboratory. Further, more than a third of those reports (103) have been published during the period January 2004 to June 2007 (approximately the duration of the current NIH grant). As measured by the subjects of these publications, use of GENESIS has a growing emphasis on two types of simulations, those of large scale networks (using the parallel version of the platform), and those involving molecular biological modeling. GENESIS remains the only simulation system specifically designed from the outset to link multi-scale modeling efforts. With this grant, we seek continuing funding to support the expanding use of GENESIS, but also and importantly, to complete the implementation of a new version of the GENESIS platform. While maintaining backwards compatibility, GENESIS 3.0 is a complete rewrite and redesign of the system, replacing a 19-year-old structure. The rewrite will update and upgrade core GENESIS functionality while adding important new features, including model history control and tracking, a new web browser interface, and new features to support education as well as scholarly publication of models. Project Narrative Biological simulation technology is becoming an increasingly important part of both basic and translational research in medicine. The GENESIS system supported by this grant is one of the most used software systems supporting this type of research in the US, and will provide continuing support for the use and further development of this modeling platform. Newly proposed extensions include applications to medical education and scientific publishing as well as the continuing efforts to understand brain function and dysfunction.

描述（由申请人提供）：一般的神经模拟系统（Genesis）于1988年首次发布供一般用途，作为马萨诸塞州伍兹霍尔的海洋生物学实验室的计算神经科学会议的第一个方法的一部分。自19年前最初发行以来，创世记为计算神经科学增长的基础之一提供了一个继续支持教育和研究的基础。关于夏季课程，Genesis继续成为伍兹霍尔（Woods Hole）课程的一部分，以及欧盟，墨西哥，印度，日本的课程，以及最近在巴西为拉丁美洲提供的新课程。最终，Genesis还为世界各地的至少61所大学和大学提供了支持，在这些课程中，它既被用作神经系统现实建模的指导工具，又是基于模拟的神经生物学教育工具。旨在支持计算和神经生物学教学的《创世纪书》（Bower and Beeman，1994，1998）已在全球范围内售出了6,000多份，其中已在Internet上免费提供的文本（Bower and Beeman和Beeman，2003年），其副本已售出了两倍以上。对在教学中使用创世纪的大力支持也为在生物学研究中广泛使用该软件系统的使用提供了基础。尽管肯定是低估的，但我们知道有297个已发表的依赖于创世纪的同行评审的期刊文章和书籍章节与P.I.实验室的研究不直接相关。此外，在2004年1月至2007年6月的期间（大约是当前NIH赠款的持续时间），这些报告中有三分之一以上已发表。正如这些出版物的主题衡量的那样，Genesis的使用越来越重视两种类型的模拟，即大规模网络的模拟（使用平台的并行版本）以及涉及分子生物学建模的模拟。 Genesis仍然是从一开始就专门设计的唯一一个模拟系统，可以链接多尺度建模工作。有了这笔赠款，我们寻求持续的资金来支持创世纪的扩大使用，但也重要的是，以完成新版本的Genesis平台的实现。在保持向后兼容的同时，Genesis 3.0是对系统的完整改写和重新设计，取代了19岁的结构。重写将更新和升级核心创世纪功能，同时添加重要的新功能，包括模型历史控制和跟踪，新的Web浏览器界面以及支持教育的新功能以及模型的学术发布。项目叙事生物模拟技术正成为医学基础研究和转化研究的越来越重要的部分。该赠款支持的创世纪系统是支持美国此类研究的最常用的软件系统之一，并将为该建模平台的使用和进一步开发提供持续的支持。新提出的扩展包括在医学教育和科学出版中的申请以及了解大脑功能和功能障碍的持续努力。