Research Core

研究核心

• 批准号: 7698457
• 负责人: George Fu Gao
• 金额: $ 12.3万
• 依托单位: NATIONAL CENTER FOR AIDS/STD CONTROL AND PREVENTION
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-29 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7698457
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adverse effects; Anti-Retroviral Agents; Caring; Characteristics; China; Chinese People; Chinese Traditional Medicine; Classification; Clinical; Clinical Data; Clinical Management; Clinical Research; Clinical Trials; Cohort Studies; Collection; Communicable Diseases; Conduct Clinical Trials; Data; Diagnostic; Diagnostic Procedure; Disease; Disease Progression; Economics; Effectiveness; Face; Guidelines; HIV; HIV Infections; HIV prevention trials network; HIV vaccine; Hand; Health Professional; Healthcare; Hepatitis C virus; Highly Active Antiretroviral Therapy; Hospitals; Immunologics; Incidence; Laboratories; Medical; Medicine; Modality; Monitor; Morbidity - disease rate; Numbers; Palliative Care; Palliative Medicine; Patients; Persons; Pharmaceutical Preparations; Prevalence; Preventive; Province; Randomized; Randomized Clinical Trials; Rate; Reporting; Research; Research Project Grants; Retrospective Studies; Screening procedure; Services; Site; Staging; Standards of Weights and Measures; Symptoms; Testing; Traditional Medicine; Training; Viral Load result; World Health Organization; antiretroviral therapy; clinical epidemiology; design; experience; innovation; mortality; pandemic disease; prospective; response

The first AIDS case was reported in 1985 in China. Since early 1994, the rate of HIV infection has rapidly increased in many provinces in China. AIDS is also becoming a significant health care concern in China, and it is expected that more and more HIV infected persons will begin to show clinical symptoms. As a result, three clinical HAART trails are being carried out in China since 1999. The data provide first-hand experience of treating HIV-infected patients in China. However, the problems with these drugs are their adverse side effects. Moreover, the drugs are too expensive to treat HIV infected persons and AIDS patients in China. The rise in HIV infection is a serious situation that calls for new innovations by the Chinese medical and health professionals in order to control the pandemic of HIV infection in China. To demonstrate the clinical and economic benefits of antiretroviral treatment over routine care, which usually consists of Chinese traditional herbal medicine, and palliative care. The specific aims for this project are: 1. To document the clinical presentations of patients with HIV through a retrospective clinical chart review. Presenting symptoms, OI presentations, stage of disease, diagnostic and monitoring tests used, treatment modalities, preventive treatments used, and mortality and morbidity parameters will be examined. 2. To characterize the clinical presentations of patients with HIV through a prospective collection of clinical data. Preventive care, screening, presenting symptoms, Ol presentations, diagnostic procedures, stage of disease by CD4/viral load. Data collected from Aims 1 and 2 will be used to accomplish Aim 4. 3. To provide systematic training in HIV clinical management to clinicians who will offer long-term HIV care to prevalent and incident cases determined through CIPRA activities. 4. To establish National Guidelines for the comprehensive clinical management of patients infected with HIV. 5. To conduct a randomized clinical trail to compare the efficacy of HAART with that of traditional Chinese medicine (TCM). 6. To evaluate the virologic responses (emphasize on rebound) and immunologic responses in HIV/HCV co-infected patients before, during and after HAART and treatment with TCM.

第一个艾滋病案件于1985年在中国报道。自1994年初以来，艾滋病毒感染率迅速增加 中国的许多省。艾滋病也在中国成为重要的医疗保健问题，预计会更多 更多的艾滋病毒感染者将开始表现出临床症状。结果，三个临床HAART步道正在 自1999年以来在中国进行。数据提供了治疗中国艾滋病毒感染患者的第一手经验。 但是，这些药物的问题是它们的不良副作用。而且，药物太昂贵了，无法治疗 艾滋病毒感染了中国的患者和艾滋病。艾滋病毒感染的兴起是一个严重的情况，需要新的 中国医学和卫生专业人员的创新是为了控制中国艾滋病毒感染的大流行。 为了证明抗逆转录病毒治疗对常规护理的临床和经济利益，这通常包括 中国传统草药和姑息治疗。该项目的具体目的是： 1。通过回顾性的临床图审查记录HIV患者的临床表现。呈现 症状，OI表现，疾病阶段，所使用的诊断和监测测试，治疗方式，预防性 将检查所使用的治疗，死亡率和发病参数将被检查。 2。通过前瞻性收集临床数据来表征HIV患者的临床表现。 预防性护理，筛查，表现症状，OL演示，诊断程序，疾病阶段 CD4/病毒负荷。从目标1和2收集的数据将用于完成目标4。 3。向临床医生提供艾滋病毒临床管理的系统培训，这些临床医生将提供长期的艾滋病毒护理 通过CIPRA活动确定的流行和事件案件。 4。建立针对感染艾滋病毒的患者的全面临床管理的国家指南。 5。进行一条随机临床步道，以将HAART与传统中药的功效进行比较 （TCM）。 6。评估艾滋病毒/HCV共感染的病毒学反应（强调反弹）和免疫反应 HAART之前，之中和之后的患者和TCM治疗。