GENETIC ARCHITECTURE OF THE BABOON CRANIOFACIAL COMPLEX

狒狒颅面复合体的遗传结构

• 批准号: 7562482
• 负责人: Richard J Sherwood
• 金额: $ 5.31万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562482
• 关键词: Address; Adolescent; Animal Model; Animals; Architecture; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Development; Funding; Genetic; Genotype; Grant; Heritability; Human; Individual; Institution; Measures; Morphogenesis; Morphology; Nature; Numbers; Papio; Phenotype; Pilot Projects; Research; Research Personnel; Resources; Sampling; Skeleton; Source; United States National Institutes of Health; Variant; Work; craniofacial; craniofacial complex; cranium; model development; programs; trait; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate objective of this NIH-funded model development study (R21 DE016408), made possible by preliminary data collection supported by the SNPRC Pilot Study Program (see Project number 0386), is to elucidate fundamental aspects of the genetic architecture of the baboon craniofacial complex in order to develop an appropriate animal model for study of the genetic contributions to human craniofacial morphogenesis. It is extending the cross-sectional data available for approximately 400 adolescent and young adult baboons to a sample of nearly 800 pedigreed, genotyped animals. Understanding the nature of genetic influences on the regions of the cranium are of critical importance to a wide variety of clinicians. Heritability estimates for various traits provide important information when attempting to reconstruct or surgically alter the craniofacial skeleton in a growing individual. The significance of this research will be the elucidation of the genetic architecture of the growing craniofacial complex. Recent work in humans has revealed that many endocranial traits are significantly heritable, and traits located in different developmental components of the cranium appear to be under differential genetic control. Examination of genetic contributions to normal variation in the baboon craniofacial complex is addressed in two specific aims: 1) Collect quantitative measures of craniofacial morphology in baboons in order to characterize variation in biomedically-relevant phenotypes. 2) Explore fundamental aspects of the genetic architecture of craniofacial morphology in baboons.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项由NIH资助的模型开发研究（R21 DE016408）的最终目标是由SNPRC Pilot研究计划支持的初步数据收集（请参阅项目编号0386），是为了阐明baboon颅面复合物的基本颅面建筑的基本方面，以开发适当的动物模型的人类crphial crphial conteni conteni conteni conteni conteni conteni conteni conteni conteni conteni conteni贡献。 它正在扩展大约400名青少年和年轻狒狒的横截面数据，以将近800种基因分型动物的样本。 了解遗传影响对颅骨区域的性质对于各种临床医生至关重要。 在尝试重建或手术改变成长中的颅面骨骼时，各种特征的遗传力估计提供了重要信息。 这项研究的意义将是阐明不断增长的颅面复合物的遗传结构。 人类最近的工作表明，许多族裔性状都是显着的，并且位于颅骨不同发育成分的特征似乎处于差异遗传控制之下。 在两个具体目的中解决了对狒狒颅面复合物正常变异的遗传贡献的检查：1）收集狒狒中颅面形态的定量测量，以表征生物医学相关的表型的变化。 2）探索狒狒颅面形态的遗传结构的基本方面。