GENETIC ARCHITECTURE OF THE BABOON CRANIOFACIAL COMPLEX

狒狒颅面复合体的遗传结构

• 批准号: 7957904
• 负责人: Richard J Sherwood
• 金额: $ 3.25万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-06 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957904
• 关键词: Address; Adolescent; Animal Model; Animals; Architecture; Computer Retrieval of Information on Scientific Projects Database; Data; Data Collection; Development; Funding; Genetic; Genotype; Grant; Heritability; Human; Individual; Institution; Measures; Morphogenesis; Morphology; Nature; Papio; Phenotype; Pilot Projects; Primates; Research; Research Personnel; Resources; Sampling; Skeleton; Source; United States National Institutes of Health; Variant; Work; craniofacial; craniofacial complex; cranium; model development; programs; trait; young adult

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate objective of this NIH-funded model development study (R21 DE016408), made possible by preliminary data collection supported by the SNPRC Pilot Study Program (see Project number 0386), is to elucidate fundamental aspects of the genetic architecture of the baboon craniofacial complex in order to develop an appropriate animal model for study of the genetic contributions to human craniofacial morphogenesis. It is extending the cross-sectional data available for approximately 400 adolescent and young adult baboons to a sample of nearly 800 pedigreed, genotyped animals. Understanding the nature of genetic influences on the regions of the cranium are of critical importance to a wide variety of clinicians. Heritability estimates for various traits provide important information when attempting to reconstruct or surgically alter the craniofacial skeleton in a growing individual. The significance of this research will be the elucidation of the genetic architecture of the growing craniofacial complex. Recent work in humans has revealed that many endocranial traits are significantly heritable, and traits located in different developmental components of the cranium appear to be under differential genetic control. Examination of genetic contributions to normal variation in the baboon craniofacial complex is addressed in two specific aims: 1) Collect quantitative measures of craniofacial morphology in baboons in order to characterize variation in biomedically-relevant phenotypes. 2) Explore fundamental aspects of the genetic architecture of craniofacial morphology in baboons.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项由 NIH 资助的模型开发研究 (R21 DE016408) 的最终目标是阐明狒狒颅面复合体遗传结构的基本方面，该研究是通过 SNPRC 试点研究计划（参见项目号 0386）支持的初步数据收集而实现的。为了开发合适的动物模型来研究遗传对人类颅面形态发生的贡献。 它正在将大约 400 只青少年和年轻成年狒狒的可用横截面数据扩展到近 800 只纯种、基因分型动物的样本。 了解遗传对颅骨区域影响的本质对于众多临床医生来说至关重要。 当尝试重建或通过手术改变成长个体的颅面骨骼时，各种性状的遗传力估计提供了重要信息。 这项研究的意义在于阐明不断生长的颅面复合体的遗传结构。 最近对人类的研究表明，许多颅内特征具有显着的遗传性，位于颅骨不同发育部分的特征似乎受到不同的遗传控制。 检查遗传对狒狒颅面复合体正常变异的贡献有两个具体目标：1）收集狒狒颅面形态的定量测量，以表征生物医学相关表型的变异。 2) 探索狒狒颅面形态遗传结构的基本方面。