GENETIC ARCHITECTURE OF THE BABOON CRANIOFACIAL COMPLEX

狒狒颅面复合体的遗传结构

• 批准号: 7349877
• 负责人: Richard J Sherwood
• 金额: $ 1.16万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-01 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349877
• 关键词: GENETIC; ARCHITECTURE; BABOON; CRANIOFACIAL; COMPLEX

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ultimate objective of the proposed pilot study is to elucidate fundamental aspects of the genetic architecture of the baboon craniofacial complex in order to develop an appropriate animal model for study of the genetic contributions to normal variation in the human craniofacial complex. Understanding the nature of genetic influences on the regions of the cranium is of primary concern to a wide variety of clinicians. As it becomes increasingly possible to incorporate gene therapy and tissue engineering when approaching repair of craniofacial dysmorphology, studies that elucidate the genetic underpinnings of continuous phenotypes typifying normal variation in craniofacial morphology are of critical importance. The significance of this research will be the elucidation of the genetic architecture of the craniofacial complex in a species in phylogenetic proximity to humans. Examination of genetic contributions to normal variation in the baboon craniofacial complex will be addressed in two specific aims: 1) Collect quantitative measures of craniofacial morphology in baboons in order to characterize variation in biomedically-relevant phenotypes. 2) Explore fundamental aspects of the genetic architecture of craniofacial morphology in baboons. Fourteen craniometric points will be marked on lateral cephalographs of a sample of 400 baboons from the Southwest National Primate Research Center. Twenty linear and 5 angular metrics will be taken for each animal based on the craniometric points. A maximum likelihood variance decomposition method for pedigree data using the algorithm implemented in the software program SOLAR is the analytic platform for the analyses. Heritability of each trait will be estimated, and genetic and environmental correlations matrices will be examined for all traits. Additionally, preliminary linkage analysis will begin to look for Quantitative Trait Loci (QTL) harboring genes influencing variation in adult craniofacial morphology in baboons. This study of the genetic architecture of the craniofacial complex in baboons will provide the necessary ground work needed to establish the baboon as an animal model for the study of genetic and non-genetic influences on craniofacial variation.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。拟议的试点研究的最终目标是阐明狒狒颅面配合物的遗传结构的基本方面，以开发适当的动物模型，以研究对人类颅颅配合物正常变异的遗传贡献。了解遗传影响对颅骨区域的性质是各种各样的临床医生的主要关注点。随着在接近颅面畸形的修复时，越来越有可能纳入基因治疗和组织工程，研究阐明了连续表型的遗传基础，这些遗传基础是颅面形态正常变化的连续表型的重要性。这项研究的意义将是阐明颅面复合物在某种物种中的遗传结构，在与人类的系统发育附近。在两个具体目的中将解决对狒狒颅面复合物正常变异的遗传贡献的检查：1）收集狒狒中颅面形态的定量测量，以表征生物医学相关的表型的变化。 2）探索狒狒颅面形态的遗传结构的基本方面。从西南国家灵长类动物研究中心的400个狒狒样品样品的侧面头造影仪将标记14个颅骨计量点。根据颅骨计量点，将对每只动物进行二十个线性和5个角度指标。使用软件程序太阳能中实现的算法的谱系数据的最大似然方差分解方法是分析的分析平台。将估算每个性状的遗传力，并将检查所有特征的遗传和环境相关性矩阵。此外，初步的连锁分析将开始寻找藏有基因的定量性状基因座（QTL），这些特质含有影响狒狒成人颅面形态变化的基因。这项对狒狒颅面复合物遗传结构的研究将为建立狒狒作为动物模型所需的必要基础工作，以研究对颅面变异的遗传和非遗传影响。