Cortical control and biomechanics of tongue movement

舌头运动的皮质控制和生物力学

基本信息

批准号：
10781477
负责人：
Nicholas G Hatsopoulos
金额：
$ 66.12万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-20 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10781477
关键词：
3-Dimensional Automobile Driving Behavior Behavioral Bilateral Biomechanics Brain Complement Data Degenerative Disorder Deglutition Deglutition Disorders Development Diet Modification Dysarthria Electrodes Elements Exercise Feeding behaviors Food Health Human Hydromorphone Implant Intramuscular Jaw Joints Left Link Liquid substance Macaca Macaca mulatta Malignant Neoplasms Malnutrition Mastication Mechanics Morbidity - disease rate Motor Cortex Movement Muscle Musculoskeletal System Neurons Neurosciences Operative Surgical Procedures Oral cavity Organ Patients Pneumonia Population Property Prosthesis Quality of life Research Research Project Summaries Role Shapes Signal Transduction Solid Speech Stroke Study models System Techniques Testing Tongue Traction Training Variant biomechanical model biomechanical test brain machine interface drinking exercise rehabilitation feeding grasp human mortality innovation insight kinematics meetings mind control motor control neural neuroprosthesis nonhuman primate noninvasive brain stimulation oral behavior orofacial pressure rehabilitation strategy sensory cortex tongue biomechanics tongue root

项目摘要

PROJECT SUMMARY This research will break new ground in sensorimotor neuroscience by relating cortical and muscle activity data to shape change in a soft-bodied organ, making it possible to evaluate the generalizability of basic principles of motor control across musculoskeletal systems. It will develop and test a computational biomechanical model of tongue function that relates muscle activity to tongue movements, complementing ongoing modeling studies of human tongues based on more limited kinematic and muscle activity data. By using variation in natural feeding behavior to elicit a range of hyolingual kinematics, the research will provide insight into the impact of dietary modification—a treatment for dysphagia—on hyolingual kinematics. This research will lay the groundwork for development of hyolingual neuroprostheses driven by cortical signals to facilitate chewing and swallowing after (e.g., cancer) surgery or degenerative diseases, and for better techniques for non-invasive brain stimulation, muscle stimulation, and rehabilitation exercises used in treatment of, e.g., dysphagia and dysarthria.

项目摘要这项研究将通过将皮质和肌肉活性数据与感觉运动神经科学的新基础打破。塑造柔软的器官中的变化，使得评估基本原理的普遍性跨肌肉骨骼系统的运动控制。它将开发和测试一个计算生物力学模型将肌肉活动与舌头运动相关的舌功能，完成了正在进行的建模研究人类舌头基于更有限的运动学和肌肉活动数据。通过在自然喂养中使用变化为引发一系列文明运动学的行为，这项研究将为饮食的影响提供洞察力修改 - 一种吞咽困难的治疗方法 - 文论运动学。这项研究将为由皮质信号驱动的文明的文论神经ph虫的发展，以促进咀嚼和吞咽（例如，癌症）手术或退化性疾病，以及用于非侵入性脑刺激的更好的技术，肌肉刺激和用于治疗，例如吞咽困难和颤音的康复运动。