Renovating Existing SPF Macaque Housing Space for the WNPRC

为 WNPRC 翻新现有 SPF 猕猴住房空间

• 批准号: 7433958
• 负责人: Saverio Vincent Capuano
• 金额: $ 48.02万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7433958
• 关键词: Adult; Animal Housing; Animals; Applications Grants; Area; Breeding; Cercopithecine Herpesvirus 1; Diarrhea; Discipline of Nursing; Effectiveness; Female; Funding; Health; Housing; Human Resources; Incidence; Macaca; Macaca mulatta; Primates; Research; Research Personnel; Research Proposals; Research Support; SIV; Services; Simian Retroviruses; Virus; Wisconsin; animal breeding; germ free condition; improved; male; programs

DESCRIPTION (provided by applicant): Currently, the Specific Pathogen Free rhesus macaque breeding colony of the Wisconsin National Primate Research Center consists of 187 adult breeding animals(134 females and 53 males), 102 offspring that will be utilized as replacement breeders as they mature (75 females, 27 males), and 38 nursing offspring (22 females, 16 males).The viruses that have been eliminated from this breeding colony are Cercopithecine herpesvirus 1, Type D Simian Retrovirus, Simian T-Lymphotropic Virus, and Simian Immunodeficiency Virus. Despite the fact that the colony has been reproductively successful since its inception in 2002, the incidence of diarrhea in the portion of the colony that is housed in stationary caging is quite high. The personnel of the Animal Services Division of the Center believe that the incidence of diarrhea is related directly to the stationary cages where these animals are housed. The specific aim of this revised grant proposal is to obtain funding to replace all of the stationary caging that remains in the Specific Pathogen Free area with contemporary mobile caging. Funding of this renovation project will have positive effects on the overall health of the SPF colony; will improve the effectiveness and efficiency of the Division's husbandry program; and will provide the Center's investigators with the specific pathogen free macaques and research support they require to successfully perform their funded research proposals.

描述（由申请人提供）：目前，威斯康星州国家灵长类动物研究中心的特定特定病原体的猕猴育种cloy菌clo菌colony由187种成人育种动物（134名女性和53名男性）组成，102个后代，将被用作成熟的繁殖者（75位女性，27名男性），和38名女性妇女（228岁的女性）（228岁的女性）（228岁的女性）（228岁的女性）（22岁）从这种繁殖群体中消除的是Cercopithecine疱疹病毒1，D型拟南芥逆转录病毒，Simian T-淋巴细胞性病毒和Simian免疫缺陷病毒。尽管自2002年成立以来，该殖民地一直在生殖成功，但在固定笼中容纳的殖民地部分腹泻的发生率很高。该中心动物服务部的人员认为，腹泻的发病率与这些动物所容纳的固定笼直接相关。这项修订的赠款提案的具体目的是获得资金，以替代使用现代移动笼中保留在特定无病原体区域中的所有固定笼子。这个翻新项目的资金将对SPF殖民地的整体健康产生积极影响；将提高该部门的饲养计划的有效性和效率；并将为中心的调查人员提供他们成功执行其资助的研究建议所需的特定无病原体猕猴和研究支持。