Improving WNPRC Infrastructure to Support HIV/AIDS Research

改善 WNPRC 基础设施以支持艾滋病毒/艾滋病研究

• 批准号: 8219360
• 负责人: Saverio Vincent Capuano
• 金额: $ 91.55万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-22 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8219360
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Aging; Animals; Area; Breeding; Ensure; Floor; Funding; HIV; Housing; Individual; Macaca; Macaca mulatta; Mental Health; Pathogenesis; Primates; Protocols documentation; Research; Research Infrastructure; Research Personnel; SIV; Specific Pathogen Frees; United States National Institutes of Health; Well in self; Wisconsin; animal care; germ free condition; improved; programs; vaccine development

DESCRIPTION (provided by applicant): The Wisconsin National Primate Research Center (WNPRC) supports an active HIV/AIDS research program with greater than $8,000,000 in funding from the National Institutes of Health and private entities. WNPRC investigators infect rhesus macaques of Indian ancestry and cynomolgus macaques of Mauritian origin with Simian Immunodeficiency Virus (SIV) to study HIV pathogenesis and vaccine development. Currently, 205 macaques (153 rhesuses, 52 cynomolgus) assigned to 27 individual projects covered by 20 different animal care and use protocols are utilized for HIV/AIDS research at the WNPRC. WNPRC investigators acquire macaques for HIV/AIDS projects from the Center's own Specific Pathogen Free (SPF) breeding colony. This proposal seeks to acquire funding to replace aging stationary caging in the SPF breeding area with contemporary mobile caging. The proposal also seeks funding to augment the existing mobile caging to improve the psychological well being of the SPF colony and the SIV-infected macaques housed at the WNPRC. Finally, this proposal also seeks funding to upgrade the physical infrastructure (e.g., doors, flooring) of the SPF and SIV-infected macaque housing areas of the WNPRC. Successful completion of the aims outlined in this proposal will ensure that WNPRC investigators performing ZHIV/AIDS research are provided with quality animals and that the psychological health of these animals is protected.

描述（由申请人提供）：威斯康星州国家灵长类动物研究中心（WNPRC）支持一项活跃的艾滋病毒/艾滋病研究计划，其资金超过8,000,000美元，来自国立国家卫生研究院和私人实体。 WNPRC研究者感染了印度血统和毛毛猕猴的猕猴，以及拟南芥免疫缺陷病毒（SIV）研究HIV发病机理和疫苗发育。目前，在WNPRC上，将205个猕猴（153个恒河猴，52个Cynomolgus）分配给了20种不同的动物护理和使用方案的27个单独的项目。 WNPRC研究人员从中心自己的特定病原体（SPF）繁殖殖民地中获取猕猴为艾滋病毒/艾滋病项目。该提议旨在获得资金，以用当代移动笼替换SPF育种区域中的老化固定式笼子。该提案还寻求资金来增加现有的移动笼，以改善WNPRC中SPF殖民地和SIV感染的猕猴的心理健康。最后，该提案还寻求资金来升级SPF和SIV感染的WNPRC的SPF的物理基础设施（例如，门，地板）。该提案中概述的目标的成功完成将确保为进行ZHIV/AIDS研究的WNPRC研究人员提供优质的动物，并保护这些动物的心理健康。