Massachusetts Center for Birth Defects Research and Prevention: Birth Defects Study To Evaluate Pregnancy exposureS (BD STEPS Core and Stillbirth)

马萨诸塞州出生缺陷研究和预防中心：评估妊娠暴露的出生缺陷研究（BD STEPS 核心和死产）

• 批准号: 10764493
• 负责人: MARTHA M. WERLER
• 金额: $ 90万
• 依托单位: MASSACHUSETTS STATE DEPT OF PUB HEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2027-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10764493
• 关键词: Massachusetts; Center; Birth; Defects; Research

Project Summary / Abstract The Massachusetts (MA) Center for Birth Defects Research and Prevention (MCBDRP) proposes to continue its strong track record of conducting etiologic research to identify modifiable risk factors for structural birth defects through its participation in the Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS). We will enhance our contributions by leveraging our longstanding relationship with local universities to produce future birth defects researchers. The MCBDRP brings to BD-STEPS our expertise and leadership in pharmacoepidemiology and collaborative utilization of unique data resources to be applied to all three key areas of interest named in the Notice of Funding Opportunity. Our research will utilize existing data from the National Birth Defects Prevention Study and BD-STEPS, as well as data collected in the next iteration of BD- STEPS. The MCBDRP investigators are committed and successful mentors and collaborative partners, roles that will continue and expand within BD-STEPS. Over the three and a half year grant period, the MCBDRP will complete at least seven etiologic research projects of public health significance that will aid in counseling women in considering exposures that are less likely to result in a birth defect; these projects include: 1) Assessing anti-obesity medications that have been and will continue to be approved by FDA and assessing bariatric surgical procedures that are increasingly performed which may lead to beneficial weight loss, though it is uncertain how potential nutritional deficiencies may impact subsequent pregnancies; 2) Investigating attention deficit hyperactivity disorder medications, the use of which has increased dramatically; 3) Evaluating nicotinamide adenine dinucleotide pathway inhibitors and the potential preventive effect of supplementation with niacin; 4) Evaluating medication use during pregnancy by severity classifications of congenital anomalies; 5) Gauging the complex relationship among multiple risk factors to further our understanding of birth defects; 6) Examining anti-viral medications, which are key to preventing maternal-fetal transmission but for which little is known about their safety with respect to birth defects; and 7) Leveraging the MA State Public Health Laboratory’s reportable disease database to explore the role of infections before and during pregnancy on the development of birth defects. Through these activities, the MCBDRP will be an essential partner in BD-STEPS to achieve our overall goal of translating research findings into meaningful initiatives in birth defects prevention.

项目摘要 /摘要 马萨诸塞州（MA）先天缺陷研究与预防中心（MCBDRP）继续 它进行病因学研究以确定结构性出生的可修改风险因素的良好记录 缺陷通过参与先天缺陷研究以评估妊娠暴露（BD步骤）。我们 通过利用我们与当地大学的长期关系来生产我们的贡献 未来的出生缺陷研究人员。 MCBDRP带来了BD步骤，使我们的专业知识和领导才能 药物ePidemiology和合作利用独特的数据资源将应用于所有三个关键 在资助机会通知中命名的感兴趣领域。我们的研究将利用现有数据 国家出生缺陷预防研究和BD步骤，以及在BD-下一次迭代中收集的数据 步骤。 MCBDRP调查人员致力于成功的导师和合作伙伴，角色 这将继续并在BD步骤内扩展。在三年半的赠款期内，MCBDRP将 完成至少七个具有公共卫生意义的病因学研究项目，这些项目将有助于咨询 妇女正在考虑暴露不太可能导致先天缺陷的曝光；这些项目包括：1） 评估过去并且将继续获得FDA和评估批准的抗肥胖药物 减肥手术程序越来越多，可能导致体重减轻，尽管 不确定潜在的营养缺乏可能会影响随后的妊娠； 2）调查 注意缺陷多动障碍药物的使用急剧增加； 3）评估 烟酰胺腺嘌呤二核苷酸途径抑制剂和补充的潜在预防作用 与烟酸； 4）通过先天异常的严重性分类来评估怀孕期间用药的使用； 5）衡量多个危险因素之间的复杂关系，以进一步了解出生缺陷； 6） 检查抗病毒药物，这是防止母亲传播的关键，但几乎没有 知道他们在先天缺陷方面的安全； 7）利用MA州公共卫生 实验室可报告的疾病数据库，以探讨怀孕之前和期间感染的作用 出生缺陷的发展。通过这些活动，MCBDRP将成为BD步骤中的重要合作伙伴 为了实现我们将研究发现转化为预防先天缺陷的有意义举措的总体目标。