EXPLORING MODIFIABLE FACTORS FOR FOLIC ACID RESISTANT SPINA BIFIDA

探索叶酸耐药性脊柱裂的可改变因素

• 批准号: 9022193
• 负责人: MARTHA M. WERLER
• 金额: $ 31万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9022193
• 关键词: EXPLORING; MODIFIABLE; FACTORS; FOLIC; ACID

 DESCRIPTION (provided by applicant): The prevalence of spina bifida has decreased since folic acid fortification, but an estimated 800 pregnancies are affected each year in the US to women who ingested at least the recommended daily amount (400 micrograms) of folic acid. Because spina bifida is a serious condition that has substantial impacts on families and society, further strategies for prevention are warranted. Using data collected in a large US case-control study from years 1976 to the present, preventable risk factors for folic acid-resistant spina bifid will be identified. The Boston University Slone Epidemiology Center Birth Defects Study is a unique resource with detailed data on mothers of over 1100 spina bifida cases and 9000 controls on folic acid intakes. These data allow mothers to be classified according to sufficient o insufficient intake of folic acid during the periconceptional period. Further, detailed data are available on many other potential risk factors. In this project, we will explore whether maternal folic acid intake modifies associations between spina bifida risks and maternal early pregnancy antiepileptic use, antimicrobial use, and failed oral contraceptive use. In addition, we will exploe whether maternal folic acid intake, physical activity, diet quality, or inter-pregnancy interval modifies associations between spina bifida risk and maternal Hispanic ethnicity, indicators of low socioeconomic status, obesity, and early pregnancy fever. Further, patterns of folic acid intake among control women will be assessed, according to maternal occupational class and type and by parity and inter-pregnancy interval lengths, to identify target groups of women for interventions. Lastly, findings from National Birth Defects Prevention Study will be replicated with Slone Epidemiology Birth Defects Study data on maternal use of antihistamines, anti-nauseants, and non-steroidal anti-inflammatory drugs. Findings from this project will lead toward the ultimate goal of eliminating the occurrence of spina bifida.

 描述（由申请人提供）：自叶酸强化以来，脊柱裂的患病率有所下降，但在美国，每年至少摄入推荐量（400 微克）脊柱的女性估计有 800 名怀孕受到影响。裂开是一种对家庭和社会产生重大影响的严重疾病，需要使用 1976 年美国大型病例对照研究中收集的数据来制定进一步的预防策略。波士顿大学斯隆流行病学中心出生缺陷研究是一个独特的资源，拥有超过 1100 例脊柱裂病例的母亲和 9000 名叶酸摄入对照者的详细数据。这些数据可以根据围孕期叶酸摄入量是否充足进行分类。此外，该项目还提供了许多其他潜在风险因素的详细数据。我们将探讨孕产妇叶酸摄入量是否会改变孕产妇脊柱裂风险与孕早期抗癫痫药物使用、抗菌药物使用和口服避孕药失败之间的关联。此外，我们还将探讨孕产妇叶酸摄入量、体力活动、饮食质量或其他因素之间的关系。 -怀孕间隔改变脊柱裂风险与母亲西班牙裔、低社会经济地位指标、肥胖和早孕发烧之间的关联。此外，将根据母亲的职业评估对照妇女的叶酸摄入模式。最后，国家出生缺陷预防研究的结果将与单独出生缺陷流行病学研究关于母亲使用抗组胺药、抗恶心药的数据进行重复。该项目的研究结果将导致消除脊柱裂的最终目标。