RISK FACTORS FOR FOLIC ACID-RESISTANCE SPINA BIFIDA

叶酸抵抗性脊柱裂的危险因素

• 批准号: 8141377
• 负责人: MARTHA M. WERLER
• 金额: $ 19.62万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2014-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141377
• 关键词: RISK; FACTORS; FOLIC; ACID; RESISTANCE

DESCRIPTION (provided by applicant): The prevalence of spina bifida has decreased since folic acid fortification, but an estimated 800 cases are born each year in the US to women who ingested at least the recommended daily amount (400 ug) of folic acid. Because spina bifida is a serious condition that has substantial impacts on families and society, further strategies for prevention are warranted. Using data collected in a large US case-control study from years 1988 to the present, preventable risk factors for folic acid-resistant spina bifida will be identified. The Boston University Slone Epidemiology Center Birth Defects Study is a unique resource with detailed data on mothers of spina bifida cases and controls for vitamin supplementation and dietary intakes. These data allow mothers to be classified according to sufficient or insufficient intake of folic acid during the periconceptional period. Further, detailed data are available on many other potential risk factors. The mothers of as many as 463 folic acid resistant spina bifida cases would be compared to two different control groups. One control group would comprise mothers of spina bifida offspring who ingested insufficient amounts of folic acid and the other would comprise mothers of non-malformed offspring who ingested sufficient amounts of folic acid. Comparisons will be made for factors that have previously been suggested as risk factors for neural tube defects or spina bifida, including obesity, diabetes, upper respiratory illness, fever, heat source exposure, infertility, assisted reproductive technology, smoking, alcohol, caffeine, and medication exposures. In addition, to hypothesis testing, all risk factor data, including all medications, illnesses, and nutrients, will be screened to identify new preventable risk factors.

描述（由申请人提供）：自叶酸强化以来，脊柱裂的患病率已减少，但估计每年有800例在美国出生的妇女至少摄入推荐的每日数量（400 ug）叶酸。由于脊柱裂是一种严重的疾病，对家庭和社会产生了重大影响，因此有必要采取进一步的预防策略。使用从1988年到当前的美国大型病例对照研究中收集的数据，将确定抗叶酸的脊柱裂的可预防危险因素。波士顿大学Slone Slone流行病学中心的出生缺陷研究是一种独特的资源，拥有有关脊柱裂的母亲病例的详细数据，以及补充维生素的摄入量和饮食摄入量的控制。这些数据允许母亲根据叶酸的足够或不足的叶酸摄入。此外，还有许多其他潜在风险因素可获得的详细数据。将多达463个抗叶酸脊柱裂病例的母亲与两个不同的对照组进行比较。一个对照组将构成脊柱裂后代的母亲，他们摄入了不足的叶酸，另一个将构成不酸化后代的母亲，他们摄入了足够量的叶酸。将对以前被认为是神经管缺陷或脊柱裂的风险因素进行比较，包括肥胖，糖尿病，上呼吸道疾病，发烧，热源暴露，不育症，辅助生殖技术，吸烟，酒精，咖啡因和药物药物。此外，对于假设检验，将筛选所有危险因素数据，包括所有药物，疾病和营养，以识别可预防的危险因素。