Novel Platform for Advanced MR Imaging of Animals

用于动物高级 MR 成像的新型平台

• 批准号: 7421051
• 负责人: Shahin Pourrahimi
• 金额: $ 79.32万
• 依托单位: SUPERCONDUCTING SYSTEMS, INC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-20 至 2011-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7421051
• 关键词: Address; Administrator; American; Animals; Area; Arts; Attention; Biocompatible Materials; Biological; Biomedical Research; Businesses; Caliber; Capital; Clinical; Code; Communities; Development; Diagnosis; Disease; Early Diagnosis; Economics; Engineering; Equipment; Facility Construction Funding Category; Foundations; Functional Imaging; Funding; General Hospitals; Genetically Engineered Mouse; Goals; Human; Image; Imagery; Imaging Techniques; Industry; Institution; Investigation; Laboratories; Laboratory Animals; Lead; Letters; Localized; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Manufacturer Name; Marketing; Massachusetts; Medical; Medical Research; Microscopy; Modeling; Motion; Mus; Noise; Numbers; Performance; Pharmaceutical Preparations; Phase; Physiological; Process; Production; Rattus; Research; Research Personnel; Resolution; Screening for cancer; Signal Transduction; Site; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Spectrum Analysis; Speed; Staging; Structure; System; Technology; Temperature; Testing; Today; United States National Institutes of Health; base; cancer therapy; commercialization; concept; cost; cryostat; design; improved; in vivo; innovation; instrument; magnetic field; metabolic abnormality assessment; molecular imaging; new technology; novel; novel strategies; programs; research facility; response; size; skills; tool; tumor; water diffusion

DESCRIPTION (provided by applicant): Addressing Market Needs The in-vivo MR imaging of rats and mice is widely used for modeling human cancers and developing cancer treatment drugs. An investigation into MR imaging techniques suitable for the early detection of cancer, together with its diagnosis and treatment, has shown the need for improved sensitivity, increased throughput and higher spatial and temporal resolution, in fact resolution approaching the practical resolution limits set by water diffusion and physiological motion. This clearly points to the need for higher magnetic fields. Difficult siting requirements and high magnet costs associated with such technology represent a strong barrier to investigators' access to an advanced imaging instrument of such a kind. Research in this area would greatly benefit from an increase in the number of high field MR platforms to study a larger number of genetically engineered mice as well as mice with viable human tumor models. Product Description The decision to develop and manufacture an advanced self-shielded, 14.1 T, 160 mm i.d. superconducting MRI magnet with a 1.2 m long room temperature bore can be justified because of applications that will be enabled and the need to demonstrate technology. It is the most convenient bore size for installing high performance gradients for small animal imaging and it will demonstrate technologies that can lay the foundation for manufacturing compact and economical MRI superconducting magnets operating at fields of 12 T to 20 T. Innovation impact The development of Stern's novel approach to magnet design and fabrication opens the door for fulfilling the market need for more compact and affordable high-field self-shielded MRI magnets. Furthermore, because this industry segment comprises very few suppliers, the emergence of a new competitor is expected to lead to further improvements in their performance and economy. Funding of the Phase II program will provide an opportunity for Stern to achieve milestones critical to its business development in serving the bio-medical market. Demonstration of its "enabling technologies" applied in an operational high-field MR platform would be a most valuable result of the project. The existence of a tangible "proof of concept" is expected to provide Stern with the momentum to generate the funding necessary for developing commercial products, both for animal and human MR magnets. The expected installation of the proof of concept model will be an added valuable contribution to the bio-medical research community. In Phase III, one of Stern's business goals will be to transfer its novel technologies to even larger magnets and, eventually, to human research and clinical MRI platforms. This transfer constitutes the company's main expansion scenario. This process will also establish a competitive US manufacturer of high-field MR magnet systems.

描述（由申请人提供）：满足市场需求大鼠和小鼠的体内 MR 成像广泛用于人类癌症建模和开发癌症治疗药物。对适用于癌症早期检测及其诊断和治疗的 MR 成像技术的研究表明，需要提高灵敏度、增加通量以及更高的空间和时间分辨率，事实上分辨率接近水扩散设定的实际分辨率极限和生理运动。这清楚地表明需要更高的磁场。与这种技术相关的困难选址要求和高磁体成本对研究人员获得此类先进成像仪器构成了巨大障碍。该领域的研究将大大受益于高场磁共振平台数量的增加，以研究更多的基因工程小鼠以及具有可行人类肿瘤模型的小鼠。 产品说明 决定开发和制造先进的自屏蔽 14.1 T、160 mm 内径。由于将要实现的应用以及演示技术的需要，具有 1.2 m 长室温孔的超导 MRI 磁体是合理的。它是安装用于小动物成像的高性能梯度的最方便的孔径尺寸，它将展示为制造在 12 T 至 20 T 磁场下运行的紧凑且经济的 MRI 超导磁体奠定基础的技术。 创新影响 Stern 磁体设计和制造的新颖方法的发展为满足市场对更紧凑、更经济的高场自屏蔽 MRI 磁体的需求打开了大门。此外，由于该行业细分市场的供应商很少，因此新竞争对手的出现预计将导致其绩效和经济的进一步改善。第二阶段计划的资金将为斯特恩公司提供一个机会，以实现对其服务生物医学市场的业务发展至关重要的里程碑。展示其在可操作的高场磁共振平台中应用的“使能技术”将是该项目最有价值的成果。切实的“概念验证”的存在预计将为斯特恩提供动力，以筹集开发动物和人类磁共振磁体商业产品所需的资金。概念验证模型的预期安装将为生物医学研究界做出额外的宝贵贡献。在第三阶段，斯特恩的业务目标之一是将其新技术转移到更大的磁体，并最终转移到人类研究和临床 MRI 平台。本次转让构成公司主要扩张场景。这一过程还将在美国建立一家具有竞争力的高场 MR 磁体系统制造商。