Substance Use Among Children of Alcoholics

酗酒者儿童的药物使用情况

• 批准号: 7340558
• 负责人: LAURIE A CHASSIN
• 金额: $ 63.46万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7340558
• 关键词: Accounting; Address; Adolescence; Adolescent; Adult; Affect; Age; Alcohol or Other Drugs use; Alcoholism; Belief; Child; Computer Assisted; Condition; Data; Dependence; Development; Disease; Drug effect disorder; End Point; Etiology; Event; Fathers; Generations; Heterogeneity; Individual Differences; Interview; Longitudinal Studies; Mails; Marriage; Mediating; Mediator of activation protein; Methods; Modeling; Natural History; Neighborhoods; Outcome; Parenting behavior; Parents; Participant; Pathway interactions; Performance; Prevention; Process; Prospective Studies; Psychopathology; Records; Regulation; Research; Risk; Risk Factors; Role; Sampling; Schools; Social Environment; Socialization; Specificity; Stress; Substance Use Disorder; Symptoms; Temperament; Testing; adolescent substance use; design; follow-up; grandparent; motivational processes; next generation; non-alcoholic; peer; problem drinker; psychologic; satisfaction; transmission process; Accounting; Address; Adolescence; Adolescent; Adult; Affect; Age; Alcohol or Other Drugs use; Alcoholism; Belief; Child; Computer Assisted; Condition; Data; Dependence; Development; Disease; Drug effect disorder; End Point; Etiology; Event; Fathers; Generations; Heterogeneity; Individual Differences; Interview; Longitudinal Studies; Mails; Marriage; Mediating; Mediator of activation protein; Methods; Modeling; Natural History; Neighborhoods; Outcome; Parenting behavior; Parents; Participant; Pathway interactions; Performance; Prevention; Process; Prospective Studies; Psychopathology; Records; Regulation; Research; Risk; Risk Factors; Role; Sampling; Schools; Social Environment; Socialization; Specificity; Stress; Substance Use Disorder; Symptoms; Temperament; Testing; adolescent substance use; design; follow-up; grandparent; motivational processes; next generation; non-alcoholic; peer; problem drinker; psychologic; satisfaction; transmission process

The proposed project studies the etiology, course, and consequences of substance use and substance disorders from a developmental perspective in a high risk sample. In so doing, it addresses a centrally importani question in substance use research-namely, what are the etiological pathways by which risk is transmitted across multiple generations? We predict heterogeneity in trajectories of substance use outcomes among children o alcoholics and controls, identify mediating mechanisms underlying familial alcoholism risk, andexamine emergin, risk in the next generation using a multi-method prospective study. To achieve these aims, we capitalize on a unique multigenerational high risk samplethat spans the ages from 'substance use initiation to the developmentof substance use disorders and adult "maturing out," and for whomdata (have already been collected from three generations (G1-G3). The sample includes alcoholicmothers and fathers whose alcoholism and otherdisorderswere directly ascertained. Beginning in adolescence(M=12.7 years), G2s and) their parents had 3 annual assessments.Further follow-ups (addingfull biologicalsiblings andpeerinformants) were) !done in late adolescence (Wave 4) and early adulthood (Wave 5). Wave 5 also added a baseline multimethodj [assessment of the G3 children (mean age=7.4). At the proposed follow-up, computer-assisted interviews will be conducted with G2adults, their G3adolescent] children, and the G3 adolescent's otherparent. Otherinformant data (peers for adults andteachers for adolescents) (along with school records data will be collected by mail. G3 adolescents will also perform standardized tasks assessing executive and motivational regulatory processes. A short-term 18-month longitudinal design allow; respective prediction of G3 adolescent substance use from existing baseline data as well as the newly.proposed assessments. The findings are particularly important for prevention because they focus on a high risk group,they track the natural history of substance use from its precursors to clinically important end points, they include 'Otentially modifiable factors, and they examine the transmission of risk across three generations.

拟议的项目研究物质使用和物质的病因，过程和后果 从高风险样本中的发展角度出发疾病。这样做，它解决了一个集中的重要性 物质使用中的问题（即研究），风险在跨越风险的病因途径是什么 多代人？我们预测儿童O的物质使用结果轨迹的异质性 酗酒者和对照，确定家族性酒精中毒风险的中介机制，远处胺， 使用多方法前瞻性研究的下一代风险。 为了实现这些目标，我们利用了独特的多代高风险来跨越年龄的多代高风险 '对物质使用障碍的开发和成人的开发启动“成熟”，以及谁 （已经从三代人（G1-G3）收集。样本包括酗酒者和父亲 直接确定其酒精中毒和其他疾病。从青春期开始（M = 12。7年），G2S和） 他们的父母进行了3次年度评估。Further随访（添加Fulll Liological Collings and PereerInformants）是 ！ Wave 5还增加了基线多弱点 [评估G3儿童（平均年龄= 7.4）。 在拟议的后续行动中，将与G2Adults进行计算机辅助访谈，他们的G3Adolectent] 儿童和G3青少年的另一个父母。其他信息数据（成年人和教师的同龄人） （随着学校记录数据的数据，将通过邮件收集。G3青少年还将执行标准化的任务 评估执行和动机监管过程。短期18个月的纵向设计允许； 从现有基线数据以及新的Propoped的G3青少年物质使用的相应预测 评估。这些发现对于预防尤其重要，因为它们专注于高风险群体，他们 跟踪从前体到临床重要终点的物质使用的自然历史，它们包括 ``原始的可修改因素，并检查了三代风险的传播。