The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep Diseases

心脏、肺、血液和睡眠疾病护理点推进中心

• 批准号: 10735580
• 负责人: BRYAN O BUCHHOLZ
• 金额: $ 181.84万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-22 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10735580
• 关键词: Acceleration; Address; Adoption; Advisory Committees; Affect; American; Automobile Driving; Blood; Businesses; COVID-19 pandemic; COVID-19 testing; Cardiovascular system; Caregivers; Caring; Cessation of life; Client satisfaction; Clinic; Clinical; Clinical Research; Communication; Community Health; Data; Decision Making; Development; Device or Instrument Development; Diagnosis; Disease; Disparity; Engineering; Environment; Equitable healthcare; Family; Funding; Goals; Grant; Health; Health Personnel; Health Professional; Health Promotion; Health system; Healthcare; Heart; Heart Diseases; Hematological Disease; Home; Income; Incubated; Incubators; Intellectual Property; Knowledge; Legal patent; Life; Lung; Lung diseases; Marketing; Massachusetts; Medical; Medical Device; Mentors; Methodology; Modeling; Morbidity - disease rate; Needs Assessment; Outcome; Pathway interactions; Patients; Point of Care Technology; Policy Maker; Population Heterogeneity; Prevention; Process; Provider; Quality of Care; Research; Research Personnel; Resource-limited setting; Resources; Risk; Running; Sleep; Sleep Disorders; System; Technology; Telemedicine; Therapeutic; Time; Training; Underserved Population; United States National Institutes of Health; Universities; Vision; Work; acute care; clinical development; commercialization; community engagement; cost; design; evidence base; experience; health care availability; health care quality; health equity; health management; home test; improved; industry partner; innovation; marginalized population; medical schools; mortality; new technology; novel; patient engagement; patient oriented; personalized management; point of care; prevent; programs; research clinical testing; success; technology research and development; tool; trend; trial design; virtual healthcare

Project Summary/Abstract – Overall Core American healthcare is rapidly evolving to a state where efficiency, quality and patient satisfaction are dominant drivers. Several trends are driving fundamental changes in health care: 1) an expanding scope of virtual care and telemedicine, accelerated by the COVID-19 pandemic, has changed how patients, healthcare providers, and health systems interact; 2) a growing recognition of disparities leading to an emphasis in providing healthcare equitably for historically marginalized populations; 3) an increasing appreciation for the patient as a critical stakeholder in therapeutic decision-making, leading to an emphasis on patient-centered design; and 4) increasing access to home health to enable better diagnosis, prevention and management of health conditions, as illustrated by widespread adoption of home-testing for SARS-CoV-2. Despite this rapidly changing environment, heart (cardiovascular), lung, blood, and sleep disorders (HLBS) continue to cause significant morbidity, mortality, and cost in the US and worldwide. Combined, these diseases account for 41% of deaths in the US and lead to over $400B in direct health care expenses plus lost income to affected patients and caregivers. Thus, there are urgent unmet needs in HLBS. We will address these issues with the renewal of the Center for Advancing Point of Care Technologies (CAPCaT) in HLBS Disorders. CAPCaT is a highly successful Point-of-Care Technology Research Network (POCTRN) Center that leverages our experience running a medical product incubator, the Massachusetts Medical Device Development Center (M2D2) at the University of Massachusetts (Lowell and Worcester campuses), and our experience administering grants, running, and managing solicitations, and working 1:1 with awardees to advance their technologies toward commercialization. CAPCaT expanded upon the original vision and success of M2D2 and now has its own established track record and collaborative network to develop and optimize novel POC and home-based technologies to improve the diagnosis and management of HLBS disorders. Our objectives in achieving this goal are to continue: 1) identifying, through stakeholder engagement, the most promising POC and home-based technologies to address unmet medical needs; 2) supporting developmental plans, including pathways to adoption at the point of care or in the home; and 3) training and disseminating developing POC and home-based technologies to the different stakeholders.

项目摘要/摘要 - 整体核心 美国医疗保健迅速发展到效率，质量和顾客满意度的状态 司机的严重性趋势正在推动医疗保健的根本变化：1）虚拟护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理护理！ 由COVID-19的大流行加速，远程医疗改变了患者，医疗保健提供者， 卫生系统相互作用； 2）对差异的越来越多 对历史上的边缘化人群公平； 3）对患者的关键越来越多。 治疗决策的利益相关者，导致以患者为中心的设计； 增加获得家庭健康的机会，以更好地诊断，预防和管理健康状况， 如SARS-COV-2的广泛采用所示 环境，心脏（心血管），肺，血液和睡眠障碍（HLB）继续引起重大 美国和全球的发病率，死亡率和成本，这些疾病占死亡人数的41％ 美国，直接医疗保健费用和受影响的患者的收入损失超过400B美元 护理人员。 HLBS障碍中前进的护理技术（CAPCAT）的中心。 保健技术研究网络（POCTRN）中心，该中心利用我们运行的经验 马萨诸塞州医学发展中心（M2D2）的医疗产品孵化器 马萨诸塞州（洛厄尔和伍斯特校园），我们的经验 管理查询，并与获奖者1：1合作，以推动其技术朝着商业化发展。 Capcat扩大了M2D2的最初愿景和成功，现在拥有自己的既定记录 以及协作网络，以开发和优化新颖的POC和基于家庭的技术以改善您 HLBS疾病的诊断和管理。 识别利益相关者的参与度，最有前途的POC和家庭基于家庭的技术 未满足的医疗需求； 2）支持发展计划，在护理点上无关 在家中； 3）培训和传播开发POC和家庭技术 利益相关者。

项目成果

Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution.

• DOI: 10.1101/2021.08.30.21262701
• 发表时间: 2021-09-02
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Ke, Ruian;Martinez, Pamela P;Brooke, Christopher B
• 通讯作者: Brooke, Christopher B

Respiratory Adenovirus Quantification with a Droplet Digital Polymerase Chain Reaction (ddPCR) Assay.

使用微滴数字聚合酶链式反应 (ddPCR) 测定进行呼吸道腺病毒定量。

• DOI: 10.1128/spectrum.00269-23
• 发表时间: 2023-06-15
• 期刊: Microbiology spectrum
• 影响因子: 3.7

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection.

• DOI: 10.1038/s41467-021-22072-9
• 发表时间: 2021-03-26
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Shan D;Johnson JM;Fernandes SC;Suib H;Hwang S;Wuelfing D;Mendes M;Holdridge M;Burke EM;Beauregard K;Zhang Y;Cleary M;Xu S;Yao X;Patel PP;Plavina T;Wilson DH;Chang L;Kaiser KM;Nattermann J;Schmidt SV;Latz E;Hrusovsky K;Mattoon D;Ball AJ
• 通讯作者: Ball AJ

Actigraphy: Metrics reveal it is not a valid tool for determining sleep in neonates.

• DOI: 10.1111/jsr.13444
• 发表时间: 2022-02
• 期刊: JOURNAL OF SLEEP RESEARCH
• 影响因子: 4.4
• 作者: Derbin, Matthew;McKenna, Lauren;Chin, Donald;Coffman, Brian;Bloch-Salisbury, Elisabeth
• 通讯作者: Bloch-Salisbury, Elisabeth

Emerging point-of-care technologies for anemia detection.

• DOI: 10.1039/d0lc01235a
• 发表时间: 2021-05-18
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: An R;Huang Y;Man Y;Valentine RW;Kucukal E;Goreke U;Sekyonda Z;Piccone C;Owusu-Ansah A;Ahuja S;Little JA;Gurkan UA
• 通讯作者: Gurkan UA