Joint Hypermobility and Lower Body Osteoarthritis

关节过度活动和下半身骨关节炎

基本信息

批准号：
9265789
负责人：
Yvonne M Golightly
金额：
$ 44.07万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-05-01 至 2019-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9265789
关键词：
Address Adult Affect Age Ankle Articular Range of Motion Biomechanics Biometry Body mass index Clinical County Coupled Cross-Sectional Studies Data Data Set Degenerative polyarthritis Diagnosis Disease Epidemiologist Epidemiology Exercise Female Fibrinogen Foot joint structure Genetic Goals Health Care Costs Hip Osteoarthritis Hip region structure Individual Injury Intervention Joint Laxity Joints Knee Knee Osteoarthritis Knowledge Lead Longitudinal Studies Measures Mechanics Medical Care Costs Modeling Musculoskeletal Non obese Obesity Odds Ratio Participant Patients Prevalence Prevention Prevention approach Preventive Intervention Principal Investigator Public Health Radiology Specialty Recording of previous events Reporting Research Research Personnel Rheumatology Risk Risk Factors Role Sample Size Sampling Shoes Short Interspersed Nucleotide Elements Site Stress Time Tissues Translational Research United States United States National Institutes of Health Variant Vertebral column Woman Youth age group ankle joint clinical practice defined contribution disability effective therapy experience foot hazard high risk joint function joint injury joint mobilization male men multidisciplinary neuromuscular orthotics physical therapist public health relevance radiologist sex

项目摘要

DESCRIPTION (provided by applicant): The overall goal of the proposed project is to define the contribution of joint hypermobility to lower body osteoarthritis (OA). Results of this study wil inform clinical practice and determine groups at high risk for OA who require targeted prevention or intervention approaches. The rationale for the proposed research is that: 1) joint hypermobility changes joint mechanics, 2) joint hypermobility is an expected independent risk factor for OA, and 3) joint hypermobility increases the risk of injury, a major risk factor for OA. The central hypothesis is that joint hypermobility is associated with lower body OA (lumbar spine, hips, knees, ankles, and feet) and that joint hypermobility magnifies the effects of other OA risk factors (i.e., joint injury). In Aim 1, we will assess the cross-sectional and longitudinal relationships of joint hypermobility with prevalent, incident, and progressive lumbar spine, hip, and knee OA. We will examine these relationships by age, sex, and body mass index because joint hypermobility declines with age, is more common in women than men, and varies with obesity. In Aim 2, we will evaluate whether joint hypermobility interacts with joint injury with regard to prevalent, incident, and progressive lumbar spine, hip, and knee OA. In Aim 3, we will explore the cross- sectional relationship of joint hypermobility and prevalent OA at the foot and ankle, joints that have not been examined in prior studies of joint hypermobility and OA. To achieve these aims, we will conduct the largest study to date of over 6900 participants from three large studies of participants with and without OA. OA, injury, and joint hypermobility data were consistently and identically measured across all 3 studies. The multidisciplinary team includes collaborative and productive researchers and clinicians with expertise in OA and injury epidemiology, rheumatology, musculoskeletal radiology, biomechanics, and biostatistics. The Principal Investigator is an Early Stage Investigator, an OA and injury epidemiologist, and an experienced physical therapist. She is in her final year as a NIH/NCATS (National Center for Advancing Translational Sciences) KL2 Scholar in which she is developing independent research on non-pharmacologic / non- surgical interventions for biomechanical risk factors of OA.

描述（由申请人提供）：拟议项目的总体目标是确定关节过度活动对下半身骨关节炎 (OA) 的影响，该研究的结果将为临床实践提供信息，并确定需要针对性预防的 OA 高危人群。拟议研究的基本原理是：1) 关节过度活动改变关节力学，2) 关节过度活动是 OA 的预期独立危险因素，3) 关节过度活动增加骨关节炎的风险。损伤，OA 的主要危险因素。中心假设是关节过度活动与下半身 OA（腰椎、臀部、膝盖、脚踝和脚）相关，并且关节过度活动会放大其他 OA 危险因素（即关节损伤）的影响。将评估横截面和纵向关节过度活动度与流行性、突发性和进行性腰椎、髋部和膝关节骨关节炎的关系我们将通过年龄、性别和体重指数来检查这些关系，因为关节过度活动度随着年龄的增长而下降，在女性中比男性更常见。在目标 2 中，我们将评估关节过度活动是否与常见、突发和进行性腰椎、髋关节和膝关节损伤相关。在目标 3 中，我们将探讨横断面关系。为了实现这些目标，我们将进行迄今为止最大规模的研究，涉及来自三项大型参与者研究的 6900 多名参与者。在所有 3 项研究中，对有和没有 OA 的 OA、损伤和关节过度活动数据进行了一致且相同的测量。多学科团队包括在 OA 和损伤流行病学、风湿病学、首席研究员是一名早期研究员、OA 和损伤流行病学家以及经验丰富的物理治疗师，她是 NIH/NCATS（国家转化科学促进中心）KL2 学者的最后一年。她正在开展针对 OA 生物力学危险因素的非药物/非手术干预措施的独立研究。