Attention and Memory Influences on Navigation in Alzheimer's Disease

注意力和记忆力对阿尔茨海默病导航的影响

• 批准号: 7188559
• 负责人: MARK MAPSTONE
• 金额: $ 11.83万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-15 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7188559
• 关键词: Accounting; Address; Affect; Aging; Alzheimer' s Disease; Area; Attention; Behavioral; Cerebral cortex; Cholinergic Agents; Cholinergic Agonists; Cholinergic Antagonists; Clinical Trials; Cognition; Cognitive; Competence; Cues; Development; Disorientation; Doctor of Philosophy; Dorsal; Elderly; Environment; Equipment; Event; Experimental Designs; Foundations; Functional disorder; Funding; Goals; Hand; Head; Impairment; Instruction; Laboratories; Link; Measures; Memory; Memory impairment; Mentors; Motion; Motion Perception; Movement; Patients; Pattern; Positioning Attribute; Procedures; Process; Range; Relative (related person); Reliance; Research; Research Personnel; Role; Seminal; Series; Simulate; Space Perception; Stream; Syndrome; System; Testing; Visual; Visual Fields; Visual Motion; Visual Psychophysics; Visuospatial; Work; attentional modulation; base; brain behavior; cholinergic; experience; human subject; memory process; nervous system disorder; nonhuman primate; object motion; optic flow; patient oriented research; programs; research study; size; skills; success; visual process; visual processing

DESCRIPTION (provided by applicant): Spatial disorientation is a primary manifestation of Alzheimer's disease (AD) greatly impacting functional independence. While the amnesic features of AD are well described, relatively little is known about the deficits underlying spatial disorientation. Spatial disorientation in AD has been attributed to pervasive memory dysfunction, but it can present without evident memory deficits. Alternatively, spatial disorientation in AD may reflect a reduction in the size of the spatial window of attention; the area of the visual field that is simultaneously accessed by cognition. Narrowing the attentional window might limit access to orientation cues in global patterns of optic flow and force reliance on less informative object motion cues. I propose to immerse myself in the study of spatial disorientation in Alzheimer's disease for the next five years. Through formal instruction, hands-on laboratory experience, and completion of the research plan described within. l will further develop skills in patient-oriented research leading to competence as an independent investigator. The strength of my approach is a core group of mentors selected for their expertise in addressing the proposed research topic and for their commitment to developing young investigators. Charles Dully, MD, PhD (visual psychophysics), Roger Kurlan, MD (neurological disease clinical trials), and Suzanne Corkin, PhD (behavioral studies of memory) have agreed to share their specific expertise and serve as mentors in my transition to independent investigator. The specific aims of the proposed research are 1 ) To quantify the size of the window of attention in patients with AD and investigate its effect on the use global motion (optic flow) and local motion (object) cues for determining heading, 2) To determine the contributions of spatial attention and memory systems for path integration, and 3) To explore the role of the cholinergic system as a neuro-modulator for spatial attention and global motion processing using pharmacological challenge. This funding will provide for my further development in behavioral studies of spatial attention in aging and AD and commence my programmatic approach to the study of brain-behavior relationships.

描述（由申请人提供）：空间定向障碍是阿尔茨海默病（AD）的主要表现，极大地影响功能独立性。虽然 AD 的遗忘特征已得到很好的描述，但对于空间定向障碍背后的缺陷却知之甚少。 AD 中的空间定向障碍被归因于普遍的记忆功能障碍，但它也可以在没有明显记忆缺陷的情况下出现。另外，AD 中的空间定向障碍可能反映了注意力空间窗口大小的减小。认知同时访问的视野区域。缩小注意力窗口可能会限制对全局光流模式中方向线索的访问，并迫使人们依赖信息量较少的物体运动线索。 我计划在未来五年内致力于阿尔茨海默病空间定向障碍的研究。通过正式指导、实验室实践经验以及完成其中描述的研究计划。我将进一步发展以患者为中心的研究技能，从而获得作为独立研究者的能力。 我的方法的优势在于选择了一个核心导师小组，他们在解决拟议的研究主题方面具有专业知识，并且致力于培养年轻的研究人员。 Charles Dully 医学博士（视觉心理物理学）、Roger Kurlan 医学博士（神经系统疾病临床试验）和 Suzanne Corkin 博士（记忆行为研究）已同意分享他们的具体专业知识，并在我向独立研究者过​​渡的过程中担任导师。 拟议研究的具体目标是 1) 量化 AD 患者注意窗口的大小，并研究其对使用全局运动（光流）和局部运动（物体）线索确定方向的影响，2)确定空间注意力和记忆系统对路径整合的贡献，以及3）利用药理学挑战探索胆碱能系统作为空间注意力和全局运动处理的神经调节器的作用。 这笔资金将为我在衰老和 AD 中空间注意力的行为研究方面提供进一步的发展，并开始我对大脑行为关系研究的程序化方法。