The Vervet Research Colony as Biomedical Resource

作为生物医学资源的黑长尾黑长尾猴研究群体

• 批准号: 10710813
• 负责人: Matthew Jorgensen
• 金额: $ 32.85万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10710813
• 关键词: African Green Monkey; Age; Age-associated memory impairment; Aging; Alzheimer' s Disease; Alzheimer' s disease pathology; Alzheimer’s disease biomarker; Amyloid beta-42; Animals; Behavior; Behavioral; Biological Markers; Blood; Blood specimen; Brain; Brain region; Cercopithecus tantalus; Cerebrum; Characteristics; Computer software; Data; Dementia; Development; Disease; Foundations; Functional disorder; Future; Gait speed; Glucose; Goals; Health; Hippocampus; Home; Home environment; Human; Impairment; Individual; Intervention Studies; LAMC2 gene; Light; Liquid substance; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Memory; Metabolic; Methodology; Modeling; Monitor; Motor Activity; Movement; Nerve Degeneration; Pattern; Phase; Plasma; Positioning Attribute; Positron-Emission Tomography; Preventive measure; Primates; Research; Resources; Sedation procedure; Short-Term Memory; Signal Transduction; Space Perception; Speed; Structure; System; TREM2 gene; Technology; Time; age effect; age related; aged; aging brain; amnestic mild cognitive impairment; amyloid pathology; behavior measurement; biomedical resource; cognitive testing; fluorodeoxyglucose positron emission tomography; forest; frontal lobe; glucose metabolism; mental state; metabolic rate; neurofilament; neuropathology; sensor; social group; tau-1; vervet

PROJECT SUMMARY Vervet monkeys (Chlorocebus aethiops sabaeus) develop age-related amyloid pathology that resembles very early stages of Alzheimer's disease in humans. Hippocampal hypometabolism and volume reduction occur in amnestic mild cognitive impairment in humans, a condition characterized by impaired everyday memory which often precedes development of Alzheimer's disease, but the effect of age on hippocampal function in vervets is not known. Determining how age and Alzheimer's-related biomarkers are associated with hippocampal structure and function in vervets would dramatically enhance the utility of this species as a model for age- related cognitive impairments and early-stage Alzheimer's disease. As a first, exploratory step towards characterizing hippocampal structure and function in aging vervets, the goal of this application is to develop a continuous tracking system to monitor locomotor behavior in group-housed vervets in the Vervet Research Colony at Wake Forest. This will allow us to monitor position within the home environment longitudinally for long periods of time (weeks to months) and will allow us to determine whether locomotor behavior in aging vervets displays patterns characteristic of dementia-associated "wandering" in humans. We will also measure hippocampal volume with structural MRI and metabolic activity with FDG-PET imaging, and Alzheimer's- related blood biomarkers. This will allow us to explore whether any features of movement around the home enclosure discriminate between individuals based on hippocampal volume, glucose metabolic rate, or fluid biomarkers of Alzheimer's disease. Because behavioral readouts of hippocampal function currently are mainly obtained through prolonged cognitive testing, which is resource-intensive and impractical to apply across large groups of primates, this proposal has the potential to uncover behavioral measures that can be continuously acquired and analyzed in real time and over a period of months to years that signal hippocampal dysfunction with aging and neuropathology in vervet monkeys. This will open new possibilities for using this model species to study interventions that may offset the development of Alzheimer's pathology in humans during the earliest phases of the disease.

项目摘要 Vervet猴子（Chlorocebus aethiops sabaeus）发展与年龄相关的淀粉样病理学，非常类似于 阿尔茨海默氏病在人类中的早期阶段。海马低代谢和减少体积发生在 人类中有敏感的轻度认知障碍，这种状况的特征是日常记忆受损 通常先于阿尔茨海默氏病的发展，但是年龄对黑vers次海马功能的影响是 不知道。确定年龄和阿尔茨海默氏症与海马的相关生物标志物如何相关 天文中的结构和功能将大大增强该物种的效用，作为年龄的模型 相关的认知障碍和早期阿尔茨海默氏病。作为探索性的第一步 表征海马结构和衰老的衰老的功能，该应用的目的是开发一个 连续跟踪系统，以监测Vervet研究中的小型天线中的运动行为 在维克森林的殖民地。这将使我们能够纵向监视家庭环境中的位置 长时间（每周至几个月），将使我们能够确定衰老的运动行为是否 Vervets显示了人类与痴呆相关的“徘徊”的特征。我们还将衡量 带有结构性MRI和代谢活性的海马体积，带有FDG-PET成像，而阿尔茨海默氏症 相关的血液生物标志物。这将使我们能够探索房屋周围运动的任何特征 基于海马体积，葡萄糖代谢率或液体的外壳区分个体 阿尔茨海默氏病的生物标志物。因为当前的海马功能的行为读数主要是 通过长时间的认知测试获得，这是资源密集型且不切实际的，可用于大型 灵长类动物的群体，该提案有可能发现可以不断的行为措施 实时获得和分析，并在数月到数年的时间内发出信号海马功能障碍 在Vervet猴子中衰老和神经病理学。这将为使用该模型物种开辟新的可能性 研究可能会在最早的人类病理学发展的干预措施中 疾病的阶段。