Vervet Research Colony as a Biomedical Resource

作为生物医学资源的黑长尾黑长尾猴研究群体

基本信息

批准号：
10153904
负责人：
Matthew Jorgensen
金额：
$ 72.38万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10153904
关键词：
Address African Green Monkey Age Aging Alzheimer&apos s Disease Alzheimer&apos s disease model Alzheimer&apos s disease risk Animals Applied Research Area Autopsy Behavioral Biological Biological Markers Biomedical Research Biopsy Blood Chemical Analysis Cardiometabolic Disease Caribbean region Categories Cercopithecus tantalus Cerebrospinal Fluid Clinical and Translational Science Awards Communicable Diseases Communities Consultations Data Dengue Fever Development Diabetes Mellitus Discipline Ensure Etiology Evaluation Fatty acid glycerol esters Fostering Funding Genetic Genome Genotype Health Influenza Infrastructure Investigation Lipids Longevity Maintenance Measurement Medicine Metabolic Metabolic Diseases Methodology Mothers Multimodal Imaging Muscle Neonatal Neurodegenerative Disorders Neurosciences Obesity Phenotype Physiological Plasma Play Population Primates Research Research Personnel Resources Respiratory syncytial virus Role Sampling Services Site Source Study models Synapses Technical Expertise Tissues Training Translational Research United States National Institutes of Health Vaccines Veterinarians Veterinary Pathology Viral animal resource bioimaging biomedical resource cardiometabolism career clinical care clinical phenotype comparative data archive data repository forest gene therapy genetic pedigree genetic resource human disease human model imaging capabilities imaging program interest medical schools meetings nonhuman primate novel outreach pathogen phenotypic data precision medicine programs psychosocial development repository reproductive research facility screening social group training opportunity translational model translational study vaccine development vervet β-amyloid burden

项目摘要

This application is a competing renewal of the "Vervet Research Colony as a Biomedical Resource" (VRC, P40-OD010965). The VRC is the only NIH-funded biomedical research resource for US-born vervet/African green monkeys (AGM; Chlorocebus aethiops sabaeus) and has been continuously funded since 2005. The VRC serves a wide range of local, regional and national investigators by providing animals, biological samples, data, consultation and training pertaining to the use of vervets/AGMs as multi-categorical, translational models of human disease. Since the previous renewal, the VRC has provided resources to over 100 investigators, including over 250 animals and over 1,500 biological samples, as well as data and consultation. The VRC has also provided the necessary infrastructure and technical expertise enabling the on-site use of over 600 animals across 30 different studies. The VRC has facilitated critical translational research across a wide variety of disciplines, including: a) the development of the vervet as an emerging nonhuman primate model of Alzheimer's disease risk with a focus on the assessment of amyloid burden, neurodegenerative disease biomarkers, and synaptic degeneration; b) investigations into the efficacy and enhancement of vaccines for infectious diseases such as neonatal influenza, respiratory syncytial virus, and dengue fever; c) studies focused on the etiology and health consequences of diabetes, metabolic disease and obesity; d) the development of novel, non-invasive biomedical imaging methodologies; and e) the expansion of the critical genetic resources available for vervets, including the sequencing of the vervet genome. The aims of the VRC resource are to: 1) provide the scientific community with access to animals, biological samples, data and expertise to facilitate the use of vervets for a wide-range of biomedical research; 2) to provide exceptional training opportunities for veterinarians and researchers interested in using vervets for translational research, and to serve as a platform for community and scientific outreach to foster better understanding of the use of nonhuman primates in biomedical research; and 3) to enhance the resource by engaging in applied research focused on continuing genetic and phenotypic characterization of vervets across the lifespan and evaluation of the vervet as a potential translational model in novel research areas. The VRC is a critical component of the Wake Forest Clinical and Translational Science Award (CTSA), which provides administrative support and facilitates the utilization of the VRC resource across the larger CTSA network. The VRC is able to take full advantage of a wide-range of existing research facilities within the Wake Forest School of Medicine, including multi-modal imaging capabilities, veterinary and pathology expertise, and genetic and analytic resources.

该应用程序是“黑长尾猴研究群体作为生物医学资源”的竞争性更新（VRC，P40-OD010965）。 VRC 是美国国立卫生研究院 (NIH) 资助的唯一针对美国出生的生物医学研究资源黑长尾黑颚猴/非洲绿猴（AGM；Chlorocebus aethiops sabaeus）并持续获得资助自 2005 年以来。VRC 为广泛的地方、区域和国家调查人员提供服务与黑长尾黑颚猴/AGM 使用相关的动物、生物样本、数据、咨询和培训作为人类疾病的多类别转化模型。自上次更新以来，VRC 已为 100 多名研究人员提供资源，其中包括 250 多只动物和 1,500 多只动物生物样本以及数据和咨询。 VRC 还提供了必要的基础设施和技术专业知识使 30 个国家/地区的 600 多只动物能够在现场使用不同的研究。 VRC 促进了各种重要的转化研究学科，包括：a）黑长尾黑颚猴作为新兴非人类灵长类动物模型的发展阿尔茨海默病风险，重点评估淀粉样蛋白负荷、神经退行性疾病疾病生物标志物和突触变性； b) 功效和增强的调查新生儿流感、呼吸道合胞病毒等传染病疫苗登革热; c) 研究重点是糖尿病的病因学和健康后果、代谢疾病和肥胖； d) 开发新颖的、非侵入性的生物医学成像方法； e) 扩大可用于长尾黑颚猴的关键遗传资源，包括长尾黑颚猴基因组测序。 VRC 资源的目标是： 1) 提供科学的能够获得动物、生物样本、数据和专业知识的社区，以促进使用用于广泛的生物医学研究的长尾黑颚猴； 2）提供特殊的培训机会对于有兴趣使用黑长尾猴进行转化研究的兽医和研究人员，以及作为社区和科学推广的平台，以促进更好地了解其用途非人类灵长类动物在生物医学研究中的应用； 3）通过从事应用来增强资源研究重点是长尾黑颚猴的持续遗传和表型特征长尾黑颚猴的寿命和评估作为新研究领域的潜在转化模型。 VRC 是维克森林临床和转化科学奖 (CTSA) 的重要组成部分，它提供管理支持并促进 VRC 资源的利用更大的 CTSA 网络。 VRC 能够充分利用各种现有的维克森林医学院内的研究设施，包括多模态成像能力、兽医和病理学专业知识以及遗传和分析资源。