Vervet Research Colony as a Biomedical Resource

作为生物医学资源的黑长尾黑长尾猴研究群

• 批准号: 10379068
• 负责人: Matthew Jorgensen
• 金额: $ 72.38万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10379068
• 关键词: Address; African Green Monkey; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease risk; Animals; Applied Research; Area; Autopsy; Behavioral; Biological; Biological Markers; Biomedical Research; Biopsy; Blood Chemical Analysis; Cardiometabolic Disease; Caribbean region; Categories; Cercopithecus tantalus; Cerebrospinal Fluid; Clinical and Translational Science Awards; Communicable Diseases; Communities; Consultations; Data; Dengue Fever; Development; Diabetes Mellitus; Discipline; Ensure; Etiology; Evaluation; Fatty acid glycerol esters; Fostering; Funding; Genetic; Genome; Genotype; Health; Influenza; Infrastructure; Investigation; Lipids; Longevity; Maintenance; Measurement; Medicine; Metabolic; Metabolic Diseases; Methodology; Mothers; Multimodal Imaging; Muscle; Neonatal; Neurodegenerative Disorders; Neurosciences; Obesity; Phenotype; Physiological; Plasma; Play; Population; Primates; Research; Research Personnel; Resources; Respiratory syncytial virus; Role; Sampling; Services; Site; Source; Study models; Synapses; Technical Expertise; Tissues; Training; Translational Research; United States National Institutes of Health; Vaccines; Veterinarians; Veterinary Pathology; Viral; animal resource; biomedical imaging; biomedical resource; cardiometabolism; career; clinical care; clinical phenotype; comparative; data archive; data repository; forest; gene therapy; genetic pedigree; genetic resource; human disease; human model; imaging capabilities; imaging program; interest; medical schools; meetings; nonhuman primate; novel; outreach; pathogen; phenotypic data; precision medicine; programs; psychosocial development; repository; reproductive; research facility; screening; social group; training opportunity; translational model; translational potential; translational study; vaccine development; vervet; β-amyloid burden

This application is a competing renewal of the "Vervet Research Colony as a Biomedical Resource" (VRC, P40-OD010965). The VRC is the only NIH-funded biomedical research resource for US-born vervet/African green monkeys (AGM; Chlorocebus aethiops sabaeus) and has been continuously funded since 2005. The VRC serves a wide range of local, regional and national investigators by providing animals, biological samples, data, consultation and training pertaining to the use of vervets/AGMs as multi-categorical, translational models of human disease. Since the previous renewal, the VRC has provided resources to over 100 investigators, including over 250 animals and over 1,500 biological samples, as well as data and consultation. The VRC has also provided the necessary infrastructure and technical expertise enabling the on-site use of over 600 animals across 30 different studies. The VRC has facilitated critical translational research across a wide variety of disciplines, including: a) the development of the vervet as an emerging nonhuman primate model of Alzheimer's disease risk with a focus on the assessment of amyloid burden, neurodegenerative disease biomarkers, and synaptic degeneration; b) investigations into the efficacy and enhancement of vaccines for infectious diseases such as neonatal influenza, respiratory syncytial virus, and dengue fever; c) studies focused on the etiology and health consequences of diabetes, metabolic disease and obesity; d) the development of novel, non-invasive biomedical imaging methodologies; and e) the expansion of the critical genetic resources available for vervets, including the sequencing of the vervet genome. The aims of the VRC resource are to: 1) provide the scientific community with access to animals, biological samples, data and expertise to facilitate the use of vervets for a wide-range of biomedical research; 2) to provide exceptional training opportunities for veterinarians and researchers interested in using vervets for translational research, and to serve as a platform for community and scientific outreach to foster better understanding of the use of nonhuman primates in biomedical research; and 3) to enhance the resource by engaging in applied research focused on continuing genetic and phenotypic characterization of vervets across the lifespan and evaluation of the vervet as a potential translational model in novel research areas. The VRC is a critical component of the Wake Forest Clinical and Translational Science Award (CTSA), which provides administrative support and facilitates the utilization of the VRC resource across the larger CTSA network. The VRC is able to take full advantage of a wide-range of existing research facilities within the Wake Forest School of Medicine, including multi-modal imaging capabilities, veterinary and pathology expertise, and genetic and analytic resources.

该应用程序是“ Vervet Research Colony作为生物医学资源”的竞争续约 （VRC，P40-OD010965）。 VRC是美国出生的NIH资助的生物医学研究资源 vervet/非洲绿猴（AGM；氯氏菌Aethiops sabaeus），并已被持续资助 自2005年以来。VRC通过提供各种本地，地区和国家调查员。 动物，生物样品，数据，咨询和培训与使用天文/AGM有关 作为人类疾病的多类翻译模型。自上一次续约以来，VRC 为100多名调查人员提供了资源，包括250多只动物和1,500多只动物 生物样品以及数据和咨询。 VRC还提供了必要的 基础设施和技术专业知识，可以在现场使用30多种动物 不同的研究。 VRC促进了各种各样的批判性转化研究 学科，包括：a）Vervet作为新兴的非人类灵长类动物模型的发展 阿尔茨海默氏病风险，重点是评估淀粉样蛋白负担，神经退行性 疾病生物标志物和突触变性； b）调查功效和增强的调查 传染病的疫苗，例如新生儿流感，呼吸道合胞病毒和 登革热; c）研究侧重于糖尿病的病因和健康后果 疾病和肥胖； d）新型非侵入性生物医学成像方法的发展； E）扩展可用于黄体的关键遗传资源，包括 天然基因组的测序。 VRC资源的目的是：1）提供科学 拥有动物，生物样本，数据和专业知识的社区，以促进使用 大量生物医学研究的天线； 2）提供出色的培训机会 对于有兴趣使用天文进行翻译研究的兽医和研究人员 充当社区和科学宣传的平台，以促进对使用的更好理解 生物医学研究中的非人类灵长类动物； 3）通过参与应用来增强资源 研究的重点是持续跨整个遗传和表型表征 生命周期和对新研究领域中潜在的翻译模型的评估。 VRC是Wake Forest临床和转化科学奖（CTSA）的关键组成部分， 它提供管理支持并促进VRC资源的利用 较大的CTSA网络。 VRC能够充分利用现有的广泛优势 Wake Forest医学院内的研究设施，包括多模式成像 能力，兽医和病理专业知识以及遗传和分析资源。