Vervet Research Colony as a Biomedical Resource

作为生物医学资源的黑长尾黑长尾猴研究群体

基本信息

批准号：
9471459
负责人：
Matthew Jorgensen
金额：
$ 68.93万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9471459
关键词：
Address Adolescent Aging Animal Model Animals Applied Research Award Biocompatible Materials Biological Assay Biomedical Research Blood Caribbean region Categories Cell Line Cercopithecus pygerythrus Chronic Disease Clinical Collaborations Collection Communicable Diseases Communities Community Outreach Community of Practice Data Data Collection Degenerative Disorder Dementia Development Diet Disease Dual-Energy X-Ray Absorptiometry Ensure Environment Epigenetic Process Etiology Experimental Designs Fatty acid glycerol esters Female Frequencies Funding Funding Opportunities Future Generations Genetic Genetic Transcription Genomics Grant Health Human Individual Informatics Institutes International Intervention Intervention Studies Investigation Laboratories Longevity Magnetic Resonance Imaging Modeling Modernization Molecular Monkeys Multimodal Imaging Muscle Newsletter Nutritional Outcome Pathway interactions Patients Pharmacotherapy Pilot Projects Positron-Emission Tomography Public Health Research Research Personnel Resources Risk Rodent Role SIV Sales Scientist Sex Characteristics Site Students Systems Biology Tissue Banks Tissue imaging Tissues Training Translating Transportation United States National Institutes of Health Update Veterinarians age difference animal resource biomedical resource bone imaging cardiometabolism clinical care clinical phenotype data warehouse design disorder risk forest genetic pedigree genomic tools human disease innovation liver imaging medical schools mouse model multidisciplinary neonate neurogenetics new technology nonhuman primate novel strategies novel therapeutics outreach pathogen pre-clinical programs public health relevance repository response sex symposium teacher therapy development tool vaccine development vervet web site

项目摘要

DESCRIPTION (provided by applicant): This is a competing renewal requesting support for the pathogen free, pedigreed and genomically characterized Vervet Research Colony (VRC). For the past five years the VRC has responded vigorously to an increased demand for VRC resources, including the distribution of 404 animals to the national research community and more than 100 in just the prior year. Future demand is projected to be strong owing to increased use of vervets for vaccine development, cardiometabolic disorders, and dementia studies, and because of substantial difficulties surrounding the international transportation of monkeys for research, including those from the Caribbean. The genomic sequencing of all individuals in the VRC and the resulting genomic resources now provides investigators the opportunity to apply modern systems biology to the study of disease pathobiology and to the development of new therapies and interventions for the chronic, degenerative, and infectious disorders posing the greatest risks to public health. The development of the genomic resource and updating of the pedigree continues to involve a strong collaboration with investigators from UCLA, who have partnered with Wake Forest scientists for more than a decade. As a national, multicategorical research resource, the VRC provides access to well-characterized monkeys for research on- or off site, including investigations focused on the nutritional context. The three specific aims for the VRC for the next grant period are: 1) to ensure both a minimum of 85 pathogen-free, genomically characterized vervets to the national biomedical community and the accompanying data and tissue repositories required to facilitate the systematic study of human disease and therapies; 2) to enhance the VRC's translational value by developing data and tissue repositories from controlled, repeated assessments while consuming a `Western' vs. usual laboratory chow diet, thereby providing a relevant nutritional context for understanding chronic disease risk and facilitating `omic' approaches to the study of animals across the lifespan; and 3) to continue providing the VRC as a platform for training veterinarians and other professionals in biomedical research, husbandry, clinical care, and the management of animal resources. It is important to note that the data and tissue repositories are enriched by regular collection and assay of blood, muscle, fat, and CSF; other collections, including liver, bone, and multimodal imaging (PET, MRI, CT, DXA, MEG) are available on request. To encourage maximum use of the resource and associated repositories, the VRC investigators engage in a program of scientific outreach that includes an annual national symposium, a pilot study program, a website, and a regular newsletter. The funds supporting scientific outreach are provided entirely by the Wake Forest School of Medicine. The VRC also engages in community outreach, focused largely on students in grades 4 - 12 and their teachers.

描述（由申请人提供）：这是一项竞争性更新，请求支持无病原体、纯系和基因组特征的黑长尾猴研究群 (VRC)。在过去的五年里，VRC 积极响应了对 VRC 资源不断增长的需求，包括对 VRC 资源的需求增加。向国家研究界分发了 404 只动物，去年就分发了 100 多只动物，预计未来需求将增加，以增加疫苗开发、心脏代谢方面的使用。疾病和痴呆症研究，并且由于猴子（包括来自加勒比地区的猴子）的国际运输存在巨大困难，VRC 中所有个体的基因组测序以及由此产生的基因组资源现在为研究人员提供了应用现代系统生物学的机会。疾病病理学的研究以及针对对公共健康构成最大风险的慢性、退行性和传染性疾病的新疗法和干预措施的开发基因组资源的开发和谱系的更新继续涉及与合作。加州大学洛杉矶分校 (UCLA) 的研究人员作为一个国家级多类别研究资源，VRC 与维克森林大学的科学家合作了十多年，为现场或场外研究提供了充分表征的猴子，包括针对营养环境的三个具体目标的研究。下一个资助期的 VRC 是： 1) 确保向国家生物医学界提供至少 85 个无病原体、具有基因组特征的动词，以及促进人类疾病和治疗的系统研究所需的随附数据和组织存储库； 2) 通过在食用“西方”饮食与通常的实验室食物饮食时进行受控、重复评估来开发数据和组织库，从而提高 VRC 的转化价值，从而提供相关的营养背景，从而了解慢性病风险并促进“组学”方法对动物整个生命周期的研究；3) 继续为兽医和其他生物医学研究、畜牧业、临床护理和动物资源管理方面的专业人员提供培训平台。请注意，通过定期收集和分析血液、肌肉、脂肪和脑脊液，丰富了数据和组织存储库；其他收集，包括肝脏、骨骼和多模态成像（PET、MRI、CT、DXA、MEG），可根据要求提供为了鼓励最大限度地利用资源和相关存储库，VRC 调查人员参与了一项科学推广计划，其中包括年度全国研讨会、试点研究计划、网站和定期通讯。 VRC 完全由维克森林医学院负责开展社区外展活动，主要关注 4 至 12 年级的学生及其老师。