Developmental Research Program

发展研究计划

• 批准号: 10711641
• 负责人: Kimberly K. Leslie
• 金额: $ 16.04万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-23 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711641
• 关键词: Advocate; Applied Research; Basic Science; Black race; Cancer Control Research; Clinical; Data; Dedications; Development; Discipline of obstetrics; Endometrial; Endometrial Carcinoma; Ensure; Epidemiology; Faculty; Funding; Future; Goals; Grant Review; Gynecologist; Gynecology; Institution; Knowledge; Life; Malignant Neoplasms; Minority; Monitor; New Mexico; Oklahoma; Oncologist; Outcome Assessment; Patients; Pilot Projects; Prevention strategy; Program Research Project Grants; Recommendation; Request for Applications; Research; Research Personnel; Research Project Grants; Review Committee; Route; Science; Scientist; Secure; Underrepresented Minority; Underrepresented Populations; United States National Institutes of Health; Universities; Washington; Woman; Work; anticancer research; cancer prevention; career; disability; innovation; member; novel therapeutic intervention; programs; recruit; success

PROJECT SUMMARY/ ABSTRACT The overall goals of the Route 66 Endometrial Cancer SPORE Developmental Research Program (DRP) are to support innovative, early-stage research in endometrial cancer, to develop pilot projects to the point of inclusion as full SPORE projects, to increase the number of investigators committed to endometrial cancer, and to diversify the workforce. This last goal is important because less than 3% of oncologists and less than 4% of academic obstetricians and gynecologist identify as Black. Moreover, although over 80% of those working in obstetrics and gynecology are women, fewer than 30% of tenured faculty members in Departments of Obstetrics and Gynecology are women. To achieve these goals, the Route 66 Endometrial Cancer SPORE DRP will provide one- to two-year pilot funding for projects in basic, translational, clinical, epidemiologic, and cancer prevention and control research. The DRP will be open to all three participating institutions in the SPORE (Washington University in St. Louis, University of New Mexico, and University of Oklahoma). We will encourage investigators to submit collaborative proposals with investigators from other SPOREs. We will use both NCI and institutional funding to support up to three DRP projects each year throughout the life of the SPORE. Requests for applications for DRP projects in endometrial cancer research will be released once per year. All applications will be reviewed by a Grant Review Committee consisting of scientists (representing basic and applied science) with expertise in endometrial or related cancers or relevant science, a biostatistician, a patient advocate, and ad hoc members, as necessary. Once a DRP project is funded, we will provide dedicated support to ensure success of the project, evaluate progress regularly, assess outcomes, and decide whether DRP projects should be recommended for funding as a full SPORE project in this or a future funding cycle. As a result of the DRP, bold new ideas in endometrial cancer research will be funded at the pilot stage and developed to lead to new treatment or prevention strategies. We fully anticipate that one or more DRP projects will be elevated to full SPORE projects in the next funding period. Additionally, new investigators will leverage DRP support to develop their projects, obtain preliminary data, and secure external funding and thus establish their careers in endometrial cancer research. Finally, established investigators who are new to the field will apply their knowledge and expertise to the field of endometrial cancer.

项目摘要/摘要 66号公路子宫内膜癌孢子发育研究计划（DRP）的总体目标是 支持创新的子宫内膜癌早期研究，以开发飞行员项目 包括作为全孢子项目，以增加致力于子宫内膜癌的研究人员的数量， 并使劳动力多样化。最后一个目标很重要，因为少于3％的肿瘤学家和少于 4％的学术产科医生和妇科医生将其视为黑人。而且，尽管超过80％ 在妇产科工作和妇产科工作的是女性，部门终身教师中只有不到30％ 妇产科和妇产科是女性。为了实现这些目标，66号公路子宫内膜癌孢子 DRP将为基本，转化，临床，流行病学和的项目提供一到两年的试点资金 预防癌症和控制研究。 DRP将向所有三个参与机构开放 孢子（圣路易斯华盛顿大学，新墨西哥大学和俄克拉荷马大学）。我们将 鼓励调查人员与其他孢子的调查人员提交合作提案。我们将使用 NCI和机构资金都在每年最多三个DRP项目中 孢子。在子宫内膜癌研究中为DRP项目申请的请求将发布一次 年。所有申请将由由科学家组成的赠款审查委员会进行审查（代表 基础科学和应用科学）具有子宫内膜或相关癌症或相关科学方面的专业知识， 必要的生物统计学家，患者拥护者和临时成员。 DRP项目资助后，我们将 提供专门的支持，以确保项目的成功，定期评估进度，评估结果以及 确定是否应该推荐DRP项目作为全孢子项目或将来作为一个完整的孢子项目 资金周期。由于DRP的结果，子宫内膜癌研究中的大胆新想法将在飞行员中资助 阶段并发展为新的治疗或预防策略。我们完全期望一个或多个 DRP项目将在下一个资金期间提升为完整的孢子项目。此外，新调查人员 将利用DRP支持来开发其项目，获得初步数据并确保外部资金和 因此，在子宫内膜癌研究中建立了职业。最后，成熟的调查员是新手 该领域将把他们的知识和专业知识应用于子宫内膜癌领域。