T21RS Meeting June 2022 Long Beach, California

T21RS 会议 2022 年 6 月加利福尼亚州长滩

基本信息

批准号：
10469127
负责人：
Elizabeth Head
金额：
$ 3.75万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-05 至 2023-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10469127
关键词：
Address Advocate Aging Alzheimer&apos s Disease American Applied Research Area Award Basic Science Behavioral Brain COVID-19 pandemic California Cells Chicago Chromosome 21 Clinical Research Clinical Trials Cognition Cognitive Cognitive deficits Collaborations Communication Defect Down Syndrome Event Family Funding Future Genetic Genetic Research Goals Health Human Individual Intellectual functioning disability Intellectual impairment Intelligence International Investigation Knowledge Laboratories Longevity Mentors Nerve Degeneration Neurobiology Paris, France Persons Postdoctoral Fellow Quality of life Request for Applications Research Research Personnel Scientist Senior Scientist Societies Spain Structural defect Training and Education Translating Translational Research Travel United States National Institutes of Health Universities base career comorbidity design developmental disease developmental genetics effective therapy environmental enrichment for laboratory animals graduate student high risk improved innovation knowledge base meetings middle age neuron development neuropathology next generation novel pathological aging posters programs success symposium therapeutic target transcriptomics virtual

项目摘要

PROJECT SUMMARY/ABSTRACT Down syndrome (DS) is caused by the inheritance of three rather than the expected two copies of chromosome 21, or trisomy 21. DS is characterized by specific structural abnormalities in the brain, by a range of cognitive deficits and intellectual disability, and by a significantly high risk of developing Alzheimer disease by middle age. The rapid pace of progress in DS research that has taken place in the last decade highlights the critical need for effective communication between scientists, clinicians, families and self-advocates to take basic research discoveries from the laboratory to clinical trials that benefit people with DS. Advances in DS research are not only driven by senior scientists but are dependent up on the nurturing of our next generation of junior scientists. Thus, this application requests funding to cover travel expenses of American-based junior investigators, postdoctoral fellows and graduate students to attend the Fourth International conference of the Trisomy 21 Research Society (T21RS). Attendees at this meeting will include established DS and non-DS investigators whose research directly or indirectly informs critical aspects of DS cognition, neuropathology, translational opportunities and clinical trials. The meeting will take place in Long Beach, California from June 8 to June 12, 2022. Based on our previous successes, we anticipate that this conference will lead to fruitful discussions and novel collaborations that are essential to define the future of DS research. The theme of our meeting will be Imagine, Discover, Inspire.

项目摘要/摘要唐氏综合症（DS）是由三个染色体的遗传而不是预期的两个副本引起的 21，或三体性21。DS的特征是大脑中特定的结构异常。缺陷和智力残疾，以及在中年发展阿尔茨海默氏病的高风险。在过去十年中发生的DS研究进展的迅速步伐突出了至关重要的需求科学家，临床医生，家庭和自我顾问之间的有效沟通以进行基础研究从实验室到临床试验的发现，使DS受益。 DS研究的进步不是仅由高级科学家驱动，但依赖于我们下一代初级科学家的培养。因此，本申请要求资金支付美国初级调查人员的旅行费用，博士后研究员和研究生将参加第21三届国际国际会议研究学会（T21RS）。这次会议的与会者将包括已建立的DS和非DS调查人员他们的研究直接或间接地为DS认知，神经病理学，翻译的关键方面提供了信息机会和临床试验。会议将于6月8日至6月12日在加利福尼亚州的长滩举行 2022年。根据我们以前的成功，我们预计这次会议将导致富有成果的讨论和对于定义DS研究的未来至关重要的新颖合作。我们会议的主题将是想象，发现，启发。