Core F: Neuropathology Core

核心 F：神经病理学核心

基本信息

批准号：
10454257
负责人：
Elizabeth Head
金额：
$ 59.78万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-30 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10454257
关键词：
Aging Alzheimer’s disease biomarker Autopsy Biological Markers Biometry Brain Clinical Collection Communities Data Dementia Diagnosis Dissection Down Syndrome Education Enrollment Ensure Equipment and supply inventories Family Freezing Goals Guidelines Image Individual Infrastructure Institutes Kentucky Letters Liquid substance Magnetic Resonance Imaging Measures Neurofibrillary Tangles Outcome Participant Persons Process Protocols documentation Research Research Personnel Research Support Resources Sampling Scanning Ships Site Slide Specimen Standardization Tissue Banks Tissue Sample Tissues Translations Universities alpha synuclein biobank brain tissue cerebrovascular pathology cohort data management digital pathology in vivo in vivo imaging neuroimaging neuroinflammation neuropathology novel prospective protein TDP-43 quantitative imaging repository research study symposium virtual whole slide imaging

项目摘要

Neuropathology Core Abstract The goal of the Neuropathology Core (NP) is to support research on aging and dementia in DS by systematically collecting, characterizing and disseminating tissues from brain autopsies from clinically characterized participants enrolled in ABC-DS. The NP Core component to the ABC-DS study will provide a final neuropathology diagnosis, perform post-mortem MR imaging, obtain high quality tissue for research purposes, provide an infrastructure for the dissemination of tissue, neuropathology and imaging data and interact with all cores in the ABC-DS. In addition to newly collected brains, in the first 2 years of the study, the NP Core will characterize a legacy cohort of autopsy cases (n=65) to fill in gaps in neuropathology data and acquire novel outcomes. The NP Core will provide critical data in support of Projects 1, 2 and 3. The postmortem imaging data will facilitate the translation of in vivo imaging to neuropathology in a systematic manner. Thus, the NP Core will 1) develop a brain autopsy network, 2) provide neuropathology diagnoses and contribute data to the Biostatistics and Data Management Core; 3) Serve as a repository for tissue and disseminate tissue samples; 4) acquire and share whole slide quantitative digital pathology in support of Projects 1, 2 and 3; 5) acquire post mortem neuroimaging to bridge the gap between in vivo and ex vivo autopsy studies.

神经病理学核心摘要神经病理学核心（NP）的目标是通过系统地支持DS的衰老和痴呆研究从临床表征的脑尸检中收集，表征和传播组织参与者参加了ABC-DS。 ABC-DS研究的NP核心组件将提供最终神经病理学诊断，进行验尸后MR成像，获得高质量的组织以进行研究，提供组织，神经病理学和成像数据的基础设施，并与所有人相互作用 ABC-DS中的核心。除了新收集的大脑外，在研究的前两年，NP Core将描述尸检病例的遗产队列（n = 65），以填补神经病理学数据的空白并获取新颖结果。 NP核心将提供关键数据，以支持项目1、2和3。验尸成像数据将以系统的方式促进将体内成像转化为神经病理学。因此，NP核心将 1）开发脑尸检网络，2）提供神经病理学诊断并为生物统计学贡献数据和数据管理核心； 3）作为组织的存储库，并传播组织样品； 4）获取和在支持项目1、2和3的支持下，共享整个幻灯片定量的数字病理学； 5）获取验尸神经影像学以弥合体内和体内尸检研究之间的差距。