Visuospatial Function in Parkinson's Disease

帕金森病的视觉空间功能

• 批准号: 7183505
• 负责人: Alice Cronin-Golomb
• 金额: $ 35.5万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7183505
• 关键词: Adult; Affect; Age; Alzheimer' s Disease; Area; Attention; Basal Ganglia; Brain; Cognition; Cognitive; Comprehension; Contralateral; Contrast Sensitivity; Daily; Detection; Disease; Elderly; Emotional; Ensure; Environment; Exhibits; Frequencies; Functional disorder; Gait; Health Professional; Impairment; Individual; Lateral; Lead; Left; Light; Link; Literature; Measures; Motion; Motor; NIH Program Announcements; Nerve Degeneration; Neurodegenerative Disorders; Neuropsychological Tests; Optical Coherence Tomography; Parietal; Parkinson Disease; Participant; Patient Self-Report; Patients; Pattern; Performance; Population; Problem Solving; Quality of life; Questionnaires; Reporting; Research; Retinal; Side; Signal Transduction; Source; Subgroup; Symptoms; System; Technology; Testing; Time; Translational Research; United States National Institutes of Health; Vision; Vision Tests; Visual; Visual Fields; Visuospatial; age related; clinically relevant; cognitive change; cognitive function; cognitive neuroscience; daily functioning; executive function; follow-up; healthy aging; innovation; motor impairment; normal aging; retinal nerve fiber layer; spatial vision; visual cognition; visual process; visual processing; young adult

DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a common age-related neurodegenerative disorder in which multiple aspects of visuospatial cognitive function are impaired. Spatial dysfunction arises from pathological changes in high- order association areas of the brain but also from defective input from lower-level visual processing areas. Deficits in vision are prevalent in PD but virtually nothing is known about the relation between vision, cognition, and daily function in this disorder. Also unknown are the cognitive sequelae of the side of initial motor impairment, despite PD nearly always having unilateral onset of neurodegeneration and unequivocal evidence linking spatial abnormalities to right-hemisphere dysfunction. We propose a multi-level approach to examining visuospatial dysfunction in PD. One major focus is on the visuospatial consequences of visual deficits, specifically the reduced signal strength that results from contrast sensitivity loss. An innovative aspect of the study is our use of frequency doubling technology and optical coherence tomography to assess visual (including retinal) function. A second focus is on the side of onset of motor impairment, contralateral o the hemisphere with predominant basal ganglia dysfunction. We plan to conduct control tests of motor- system and prefrontal function to ascertain the extent of independence of the occipital and parietal areas in affecting spatial function in PD. Further, we will conduct an exploration of the relation of visual and visuospatial impairments to daily function as assessed through self-report questionnaires and with an objective open-field measure of gait curvature. Assessment will occur at baseline and at one-year follow-up. We propose to examine the ability of 36 patients with left-onset PD (LPD), 36 with right-onset PD (RPD), 36 healthy age-matched adults, and 36 healthy young adults to perform on tests of vision and visuospatial function. Individuals with PD will likely exhibit poorer performance on most tests of vision and visuospatial function than age-matched adults, who in turn will exhibit poorer performance than young adults. We further expect that LPD will show more extensive visuospatial impairments than RPD, and that the pattern of impairments will distinguish the two subgroups. Our tests target visual and visuospatial symptoms reported by the patients themselves, ensuring that the elucidation of mechanisms will have clinical relevance. Demonstration of different profiles of performance in LPD and RPD would bolster arguments of selective visuospatial deficits in PD and suggest differential visual, cognitive, and functional enhancement strategies.

描述（由申请人提供）：帕金森氏病（PD）是一种常见的与年龄相关的神经退行性疾病，其中视觉空间认知功能的多个方面受损。空间功能障碍是由大脑高阶关联区域的病理变化引起的，也来自低级视觉处理区域的缺陷输入。视力不足在PD中普遍存在，但几乎没有关于这种疾病的视力，认知和日常功能之间的关系。尽管PD几乎总是具有神经变性的单侧发作和将空间异常与右半球功能障碍联系起来，但最初运动障碍的一侧的认知后遗症也未知。我们提出了一种多层次的方法来检查PD中的视觉空间功能障碍。一个主要的重点是视觉缺陷的视觉空间后果，特别是信号强度降低，这是对比度灵敏度丧失导致的。该研究的一个创新方面是我们使用频率加倍技术和光学相干断层扫描来评估视觉（包括视网膜）功能。第二个重点是运动障碍的发作侧面，对侧o半球具有主要基础神经节功能障碍。我们计划进行电动系统和前额叶功能的控制测试，以确定枕骨和顶部区域在影响PD空间功能方面的独立性。此外，我们将对视觉和视觉空间障碍与日常功能的关系进行探索，并通过自我报告问卷调查以及步态弯曲的客观开放式衡量标准。评估将在基线和一年的随访中进行。我们建议检查36例左发PD（LPD）患者的能力，36例患有右PD（RPD），36名健康年龄匹配的成年人以及36名健康的年轻人对视力和视觉空间功能进行测试。与年龄匹配的成年人相比，患有PD的个体在大多数视力和视觉空间功能测试中的性能可能会表现得更差，而年龄匹配的成年人的表现会比年轻人表现出较差的表现。我们进一步期望LPD比RPD显示出更广泛的视觉空间障碍，并且损害的模式将区分这两个亚组。我们的测试目标是患者本身报告的视觉和视觉空间症状，以确保机制的阐明将具有临床意义。 LPD和RPD中不同性能的不同概况的演示将加强PD中选择性视觉空间缺陷的论点，并提出差异视觉，认知和功能增强策略。