Effects of Parkinson's Disease on Perception, Cognition, and Gait

帕金森病对知觉、认知和步态的影响

• 批准号: 8534298
• 负责人: Alice Cronin-Golomb
• 金额: $ 58.63万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8534298
• 关键词: Adult; Affect; Area; Attention; Basal Ganglia; Behavioral; Brain; Clinical; Cognition; Cognitive; Comprehension; Contralateral; Contrast Sensitivity; Corpus striatum structure; Diagnosis; Diagnostic; Discipline; Ensure; Environment; Esthesia; Freezing; Functional Magnetic Resonance Imaging; Functional disorder; Gait; Gait abnormality; Goals; Hallucinations; Handedness; Image; Imaging Techniques; Impaired cognition; Impairment; Individual; Kinesiology; Lateral; Lead; Left; Literature; Marshal; Measures; Moods; Motor; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Neuropsychological Tests; Neuropsychology; Parkinson Disease; Patient Self-Report; Patients; Perception; Performance; Process; Psychometrics; Psychophysics; Quality of life; Relative (related person); Reporting; Research; Research Personnel; Review Literature; Role; Scientist; Side; Sleep; Source; Structure; Subgroup; Symptoms; Testing; Translations; Vision; Visual; Visual Fields; Visual Psychophysics; Visuospatial; clinically relevant; cognitive function; cognitive neuroscience; daily functioning; motor impairment; neuroimaging; neuropsychological; patient oriented; relating to nervous system; visual process; visual processing; visual stimulus

Non-motor aspects of Parkinson's disease (PD) such as deficient sensation, perception, and cognition are a source of a significant decline in everyday function and quality of life. Among the most important of daily functions that is affected in PD is visuospatial ability, which enables the perceptual and cognitive comprehension and navigation of the visual environment. Deficits in this domain arise from pathological changes in high-order association areas of the brain as well as from defective input from more basic visual processing areas, reflecting dysfunction of specific aspects of corticostriatal loops. Of potential importance to understanding the visuospatial sequelae of PD is consideration of the side of initial motor impairment, as PD nearly always has unilateral onset of neurodegeneration, and the right hemisphere is especially engaged in many aspects of visuospatial processing. We aim to define the relation between basic vision and visuospatial problems in PD and to examine underlying neural changes. In particular, we aim to elucidate the causal role of specific corticostriatal structures in visuospatial cognition and to define functional connectivity between specific cortical areas and striatal regions. We hypothesize, first, that cognitive impairments in PD reflect dysfunction in corticostriatal loops involving the rostrodorsal caudate. Second, we hypothesize that side of motor symptom onset as well as hemifield presentation of visual stimuli predict the hemispheric laterality of hypoactivation in corticostriatal loops, with stronger effects for patients with onset on the left body side (LPD) (right basal ganglia) and for left visual hemifield presentation. Our third focus is on the relation of visual and visuospatial impairments to daily function, including gait, motoric freezing, subjective quality of life, hallucinations, mood and other patient-centered features of PD. To accomplish our goals, we will marshal the expertise of scientists from complementary disciplines, including neuropsychology, visual psychophysics, cognitive neuroscience and neuroimaging, and clinical movement science. Our proposed fMRI studies provide a direct test of the hypothesis that dysfunction in specific components of corticostriatal loops, especially frontostriatal and parietostriatal loops, underlie problems on specific visuospatial and visuocognitive tasks in PD. As most cortical regions are connected with the striatum, the studies will fill a significant gap in understanding the likely ubiquitous role of corticostriatal circuits in cognition. The application of psychophysical, cognitive and imaging techniques that could predict the integrity of higher-level cognitive and daily functions in PD will be useful clinically, enabling the identification of potential spatial problems for the patient at diagnosis. Our tests target visual, visuospatial, and functional symptoms reported by the patients themselves, ensuring that the elucidation of mechanisms will have clinical relevance.

帕金森氏病（PD）的非运动方面，例如不足的感觉，感知和认知是一种 日常功能和生活质量大幅下降的来源。每天最重要的 在PD中受影响的功能是视觉空间能力，它可以使知觉和认知能力 视觉环境的理解和导航。该领域的缺陷来自病理 大脑高阶区域的变化以及来自更基本视觉的缺陷输入的变化 处理区域，反映了皮质纹状体环的特定方面的功能障碍。潜在的重要性 理解PD的视觉空间后遗症是对初始运动障碍的一侧，因为PD 几乎总是有神经变性的单侧发作，右半球特别参与 视觉空间处理的许多方面。我们旨在定义基本视野与视觉空间之间的关系 PD问题并检查潜在的神经变化。特别是，我们旨在阐明 视觉空间认知中的特定皮质纹状体结构，并定义特定之间的功能连通性 皮质区域和纹状体区域。我们首先假设PD中的认知障碍反映了功能障碍 涉及尾状尾状的皮质纹状体环。其次，我们假设运动症状的那一侧 视觉刺激的发作以及半场的表现预测了在 皮质纹状体环，对左侧身体发作（LPD）的患者具有更强的作用（右基础 神经节）和左视觉半场演示。我们的第三个重点是视觉和视觉空间的关系 日常功能的障碍，包括步态，摩托车冻结，主观生活质量，幻觉，情绪 以及其他以患者为中心的PD功能。为了实现我们的目标，我们将元帅的科学家专业知识 从互补的学科，包括神经心理学，视觉心理物理学，认知神经科学和 神经影像学和临床运动科学。我们提出的功能磁共振成像研究提供了直接测试 假设是皮质纹状体环的特定组成部分的功能障碍，尤其是额面和 侧面循环，PD中特定视觉空间和视觉认知任务的问题。大多数 皮质区域与纹状体有关，研究将填补明显的差距，以理解可能 皮质纹状体回路在认知中无处不在的作用。心理物理，认知和成像的应用 可以预测PD中高级认知和每日功能的完整性的技术将是有用的 临床上，可以在诊断时鉴定患者的潜在空间问题。我们的测试目标 患者本身报告的视觉，视觉空间和功能症状，确保 阐明机制将具有临床相关性。

项目成果

Effect of visual cues on the resolution of perceptual ambiguity in Parkinson's disease and normal aging.

• DOI: 10.1017/s1355617715000065
• 发表时间: 2015-02
• 期刊: Journal of the International Neuropsychological Society : JINS
• 作者: Díaz-Santos M;Cao B;Mauro SA;Yazdanbakhsh A;Neargarder S;Cronin-Golomb A
• 通讯作者: Cronin-Golomb A

Perceptual, cognitive, and personality rigidity in Parkinson's disease.

• DOI: 10.1016/j.neuropsychologia.2015.01.044
• 发表时间: 2015-03
• 期刊: NEUROPSYCHOLOGIA
• 影响因子: 2.6
• 作者: Diaz-Santos, Mirella;Cao, Bo;Yazdanbakhsh, Arash;Norton, Daniel J.;Neargarder, Sandy;Cronin-Golomb, Alice
• 通讯作者: Cronin-Golomb, Alice

Effects of Parkinson's disease on optic flow perception for heading direction during navigation.

帕金森病对导航过程中前进方向光流感知的影响。

• DOI: 10.1007/s00221-014-3853-9
• 发表时间: 2014
• 期刊: Experimental brain research
• 影响因子: 2
• 作者: Lin,Cheng-Chieh;Wagenaar,RobertC;Young,Daniel;Saltzman,ElliotL;Ren,Xiaolin;Neargarder,Sandy;Cronin-Golomb,Alice
• 通讯作者: Cronin-Golomb,Alice

Frontal and posterior subtypes of neuropsychological deficit in Parkinson's disease.

• DOI: 10.1037/a0031357
• 发表时间: 2013-04
• 期刊: BEHAVIORAL NEUROSCIENCE
• 影响因子: 1.9
• 作者: Miller, Ivy N.;Neargarder, Sandy;Risi, Megan M.;Cronin-Golomb, Alice
• 通讯作者: Cronin-Golomb, Alice

Bistable perception in normal aging: perceptual reversibility and its relation to cognition.

• DOI: 10.1080/13825585.2016.1173646
• 发表时间: 2017-03
• 期刊: Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
• 作者: Díaz-Santos M;Mauro S;Cao B;Yazdanbakhsh A;Neargarder S;Cronin-Golomb A
• 通讯作者: Cronin-Golomb A