Visuospatial Function in Parkinson's Disease

帕金森病的视觉空间功能

• 批准号: 7392261
• 负责人: Alice Cronin-Golomb
• 金额: $ 35.5万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7392261
• 关键词: Adult; Affect; Age; Alzheimer' s Disease; Area; Attention; Basal Ganglia; Brain; Cognition; Cognitive; Comprehension; Contralateral; Contrast Sensitivity; Daily; Detection; Disease; Elderly; Emotional; Ensure; Environment; Exhibits; Frequencies; Functional disorder; Gait; Health Professional; Impairment; Individual; Lateral; Lead; Left; Light; Link; Literature; Measures; Motion; Motor; NIH Program Announcements; Nerve Degeneration; Neurodegenerative Disorders; Neuropsychological Tests; Optical Coherence Tomography; Optics; Parietal; Parkinson Disease; Participant; Patient Self-Report; Patients; Pattern; Performance; Population; Problem Solving; Quality of life; Questionnaires; Reporting; Research; Retinal; Side; Signal Transduction; Source; Subgroup; Symptoms; System; Technology; Testing; Time; Translational Research; United States National Institutes of Health; Vision; Vision Tests; Visual; Visual Fields; Visuospatial; age related; clinically relevant; cognitive change; cognitive function; cognitive neuroscience; daily functioning; executive function; follow-up; healthy aging; innovation; motor impairment; normal aging; retinal nerve fiber layer; spatial vision; visual cognition; visual process; visual processing; young adult

Parkinson's disease (PD) is a common age-related neurodegenerative disorder in which multiple aspects of visuospatial cognitive function are impaired. Spatial dysfunction arises from pathological changes in high- order association areas of the brain but also from defective input from lower-level visual processingareas. Deficits in vision are prevalent in PD but virtually nothing is known about the relation between vision, cognition, and daily function in this disorder. Also unknown are the cognitive sequelae of the side of initial motor impairment, despite PD nearly always having unilateral onset of neurodegeneration and unequivocal evidence linking spatial abnormalities to right-hemisphere dysfunction. We propose a multi-level approach to examining visuospatial dysfunction in PD. One major focus is on the visuospatial consequencesof visual deficits, specifically the reduced signal strength that results from contrast sensitivity loss. An innovative aspect of the study is our use of frequency doubling technology and optical coherence tomographyto assess visual (including retinal) function. A second focus is on the side of onset of motor impairment, contralateral o the hemisphere with predominant basal ganglia dysfunction. We plan to conduct control tests of motor- system and prefrontal function to ascertain the extent of independence of the occipital and parietal areas in affecting spatial function in PD. Further, we will conduct an exploration of the relation of visual and visuospatial impairments to daily function as assessed through self-report questionnaires and with an objective open-field measure of gait curvature. Assessmentwill occur at baseline and at one-year follow-up. We propose to examine the ability of 36 patients with left-onset PD (LPD), 36 with right-onset PD (RPD), 36 healthy age-matched adults, and 36 healthy young adults to perform on tests of vision and visuospatial function. Individuals with PD will likely exhibit poorer performance on most tests of vision and visuospatial function than age-matched adults, who in turn will exhibit poorer performance than young adults. We further expect that LPD will show more extensive visuospatial impairments than RPD, and that the pattern of impairments will distinguish the two subgroups. Our tests target visual and visuospatial symptoms reported by the patients themselves, ensuring that the elucidation of mechanisms will have clinical relevance. Demonstration of different profiles of performance in LPD and RPD would bolster arguments of selective visuospatial deficits in PD and suggest differential visual, cognitive, and functional enhancement strategies.

帕金森氏病（PD）是一种常见的与年龄有关的神经退行性疾病，其中多个方面 视觉空间的认知功能受损。空间功能障碍是由高 - 的病理变化引起的 大脑的订单关联区域，也来自低级视觉加工的缺陷输入。 视力不足在PD中很普遍，但几乎没有关于视觉之间的关系， 认知和每日功能在这种疾病中。也未知的是初始侧面的认知后遗症 运动障碍，尽管PD几乎总是具有神经退行性的单侧发作和明确的发作 将空间异常与右半球功能障碍联系起来的证据。我们提出了一种多层次的方法 检查PD中的视觉空间功能障碍。一个主要重点是视觉的视觉空间后果 缺陷，特别是由于对比灵敏度丧失而导致的信号强度降低。创新的 该研究的方面是我们使用频率加倍技术和光学相干断层扫描来评估 视觉（包括视网膜）功能。第二个重点是运动障碍的发作侧面 o主要基底神经节功能障碍的半球。我们计划进行电动机的控制测试 系统和前额叶功能，以确定枕叶和顶部区域独立的程度 影响PD中的空间函数。此外，我们将探索视觉和 通过自我报告调查表评估的日常功能的视觉空间障碍以及 步态曲率的客观开放式测量。评估将在基线和一年的随访中进行。 我们建议检查36例左发PD（LPD），36例患者的能力，右发pd（RPD）， 36名健康年龄匹配的成年人和36名健康的年轻人进行视觉测试和视觉空间测试 功能。 PD患者在大多数视力测试和视觉空间测试中的性能较差 比年龄匹配的成年人的功能，反过来又表现出比年轻人的表现差。我们进一步 预计LPD会比RPD显示出更大的视觉空间障碍，并且 障碍将区分两个子组。我们的测试针对视觉和视觉空间症状报告 由患者本身，确保阐明机制将具有临床相关性。 LPD和RPD中不同性能的不同概况的演示将加强选择性的论点 PD中的视觉空间缺陷，并提出差异视觉，认知和功能增强策略。