Effect of Drug Use on the Legs: CVI, Mobility and Pain

吸毒对腿部的影响：CVI、活动能力和疼痛

• 批准号: 7054728
• 负责人: BARBARA A PIEPER
• 金额: $ 42.53万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7054728
• 关键词: amphetamines; ankle; behavioral /social science research tag; clinical research; cocaine; disease /disorder etiology; disease /disorder onset; disease /disorder proneness /risk; early diagnosis; foot; heroin; human middle age (35-64); human subject; intravenous drug abuse; leg; mathematical model; methadone; microcirculation; neuromuscular disorder; pain; peripheral blood vessel disorder; questionnaires; skin ulcer; venous thrombosis; young adult human (21-34)

DESCRIPTION (provided by applicant): The purpose of this study is to examine the adverse effects of illicit drug use on the legs, namely, early-onset chronic venous insufficiency (CVI), loss of mobility, and leg pain. Ranging from minor skin changes to leg ulcers that are difficult to heal, CVI is associated with restricted functioning, pain and suffering. Even persons who have stopped injecting drugs remain at risk. Our preliminary research indicates that this is a major health problem among those who have used injection drugs occurring with a prevalence of 87% in a large methadone clinic sample. The central hypotheses are that (a) the high prevalence of early onset CVI is a consequence of venous damage in the lower extremities due to injection drugs and (b) leg pain and the ensuing reduction in mobility further exacerbate the disease. Two specific aims will be addressed: (a) establish that injection use is responsible for early onset CVI and determine what other drug use variables moderate this effect, and (b) determine how ankle and general mobility and leg pain are associated with early onset CVI. This is an observation/comparative design. Clients (N=600), 30 to 60 years of age, will be recruited from substance abuse treatment centers. Eligible participants will be stratified into 3 groups according to route/site of illicit drug use. Selective sampling and statistical controls will be used to increase comparability of groups. Objective and self-report measures of drug use, leg pain, mobility, and CVI will be obtained individually form each participant. Descriptive, inferential, and structural equation model building will be used. We will extend our prior research to show the conditions under which injection drug use is responsible for early-onset CVI. We will examine leg pain and mobility as potential modifiable links between injection drug use and CVI. This research is significant because it will aid in our understanding of the mechanism of CVI and support the development of evidenced-based programs to promote leg health for those who have used injected drugs.

描述（由申请人提供）：本研究的目的是检查非法药物使用对腿部的不利影响，即早期发作的慢性静脉功能不全（CVI），移动性丧失和腿痛。从轻微的皮肤变化到难以治愈的腿溃疡，CVI与功能受限，疼痛和痛苦有关。即使是停止注射毒品的人，也仍处于危险之中。我们的初步研究表明，在大型美沙酮诊所样本中使用注射药物为87％的注射药物中，这是一个主要的健康问题。中心假设是（a）早期发作CVI的高患病率是由于注射药物引起的下肢静脉损伤的结果，以及（b）腿痛以及随之而来的流动性降低进一步加剧了这种疾病。将解决两个具体的目标：（a）确定注射使用是造成早期发作的原因，并确定其他药物使用变量适应此效果，并且（b）确定踝关节，一般的移动性和腿部疼痛与早期发作CVI如何相关。这是一个观察/比较设计。客户（n = 600），30至60岁，将从药物滥用治疗中心招募。符合条件的参与者将根据非法吸毒的路线/部位将3组分为3组。选择性抽样和统计控制将用于增加组的可比性。将单独构成每个参与者的物业和自我报告量度的药物使用，腿痛，流动性和CVI。将使用描述性，推论和结构方程模型构建。我们将扩展先前的研究，以显示注射药物使用造成早发的CVI的条件。我们将检查腿部疼痛和活动性，因为注射药物使用与CVI之间的潜在可修改环节。这项研究很重要，因为它将有助于我们理解CVI机制，并支持开发基于证据的计划，以促进使用注射药物的人的腿部健康。