Motor Control Measures at the Ankle in CP

脑瘫患者踝部的运动控制措施

• 批准号: 6796668
• 负责人: Jack R Engsberg
• 金额: $ 7.48万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6796668
• 关键词: ankle; behavioral /social science research tag; cerebral palsy; clinical research; data collection methodology /evaluation; functional ability; gait; human subject; joint disorder; mathematical model; muscle function; muscle strength; neuroregulation; spastic paralysis; ankle; behavioral /social science research tag; cerebral palsy; clinical research; data collection methodology /evaluation; functional ability; gait; human subject; joint disorder; mathematical model; muscle function; muscle strength; neuroregulation; spastic paralysis

DESCRIPTION (provided by applicant): Relative phase (a quantification of the relative timing between a pair of oscillators at the same frequency) has been used extensively in the able-bodied (AB) population to measure motor control (Collins et al., 1998), but never in cerebral palsy (CP). The purposes of this pilot investigation are to develop relative phase as a measure of motor control at the ankle for persons with CP, and relate the motor control measure to spasticity, strength, and function. Aim 1 is to develop a measure of motor control for the ankle dorsi/plantarflexors in persons with CP. Fifteen subjects with CP (CP group) and 15 with able bodies (AB group) will perform three movement tasks (1) move one (then the other) ankle to maximum dorsiplantarflexion in time with a pair of metronome beeps, (2) synchronize (i.e., in phase) their ankle movements, and (3) dorsiflex one ankle while plantarflexing the other and vice versa (i.e., antiphase). The tasks will be recorded using a motion capture system. Relative phase will be calculated between the ankle and the metronome or between the ankles. A mixed-design ANOVA will be used on the standard deviation of the relative phase measures to determine if differences exist between the CP and AB groups, and between tasks. The variability in the three relative phase tasks is expected to be less for the AB group compared to the CP group. It is hypothesized that the group differences will increase with task difficulty. Aim 2 will correlate the motor control measure with spasticity, strength, and function. The motor control measure from Aim 1 will be used with other tests to assess additional CP and AB groups (n=12 subjects/group). Subjects will be tested for motor control, spasticity, and strength, gait, gross motor function measure [GMFM]. Multiple regression will quantify relationships among the measures. The PIs hypothesize that the motor control measure will add to the amount of function variability explained by spasticity and strength. Upon completion, they will have data to initiate a more extensive study to quantify relationships between impairment measures and function.

描述（由申请人提供）：相对阶段（对相同频率的一对振荡器之间的相对时机进行定量）已在能力体现的（AB）种群中广泛使用，以测量运动控制（Collins等，1998），但从未在脑瘫（CP）中进行测量。该试验研究的目的是发展相对阶段，作为CP患者踝关节控制运动控制的量度，并将运动控制措施与痉挛，强度和功能相关联。 目的1是在患有CP的人的踝关节/plotsiflexors的运动控制中开发一种量度。 Fifteen subjects with CP (CP group) and 15 with able bodies (AB group) will perform three movement tasks (1) move one (then the other) ankle to maximum dorsiplantarflexion in time with a pair of metronome beeps, (2) synchronize (i.e., in phase) their ankle movements, and (3) dorsiflex one ankle while plantarflexing the other and vice versa (i.e.,反相）。任务将使用运动捕获系统记录。相对相将在踝关节和节拍器之间或脚踝之间计算。混合设计方差分析将用于相对相测量的标准偏差，以确定CP和AB组之间以及任务之间是否存在差异。与CP组相比，AB组的三个相对阶段任务的可变性预计将较小。假设小组差异会随着任务难度而增加。 AIM 2将将运动控制度量与痉挛，强度和功能相关联。 AIM 1的运动控制度量将用于其他测试，以评估其他CP和AB组（n = 12受试者/组）。受试者将测试运动控制，痉挛和强度，步态，总体运动功能度量[GMFM]。多重回归将量化措施之间的关系。 PI假设电动机控制度量将增加痉挛和强度解释的功能变异性量。完成后，他们将拥有数据来启动更广泛的研究，以量化损害措施与功能之间的关系。