Ankle Strengthening to Improve Gait and Function in CP

加强踝关节以改善脑瘫患者的步态和功能

基本信息

批准号：
6782578
负责人：
Jack R Engsberg
金额：
$ 21.8万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-08-01 至 2006-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6782578
关键词：
adolescence (12-20)ankle cerebral palsy clinical research data collection methodology /evaluation electromyography exercise functional ability gait human subject human therapy evaluation interview medical complication middle childhood (6-11)muscle strength patient care planning patient safety /medical error statistics /biometry

项目摘要

DESCRIPTION (provided by the applicant): Many treatments exist to improve the gait and function of persons with Cerebral Palsy (CP). Despite recognizing that muscle weakness is a major impairment in CP, none of the treatments have the direct aim of strengthening muscles. Our results from an NIH investigation (R01-NS035830) indicated high correlations between ankle strength and function, with greater strength correlated with higher function. The idea of strengthening muscles has been controversial for safety issues. The purposes of this pilot investigation are to: 1) establish sample sizes for a future randomized clinical trial determining if intensive ankle strength training programs can improve strength, gait, and function without increasing spasticity; and 2) investigate potential safety issues arising from the training programs. Aim 1: Establish sample sizes for a future randomized clinical trial determining if intensive ankle strength training programs can improve ankle strength, gait, and function without increasing spasticity. Twenty ambulatory subjects with spastic diplegia CP will be randomly assigned to one of 4 groups: 1) Dorsi-flexor strength training group; 2) Plantar-flexor strength training group; 3) Dorsi-plantarflexor strength training group; and 4) the group undergoing no intensive strength training program. Subjects in the strength training groups will participate in a 12-week progressive, resistance strength-training program. Prior to, and at the end of the training program, all subjects will be objectively assessed for ankle Plantar-flexor spasticity, ankle strength, gait, and GMFM. The data will be used in a repeated measures power analysis to establish sample sizes for the clinical trial. Aim 2: Investigate potential safety issues arising from the training programs. The aim has 2 components. The first is the weekly measurement of Plantar-flexor spasticity and tightness. The data will permit continuous monitoring of spasticity and tightness, and alert investigators to potential problems during each subject's participation. In the second component, both the pre- and post-intervention measures, and the weekly monitoring of spasticity and tightness, will determine if potential changes could be a concern for the future clinical trial.

描述（由申请人提供）：存在许多治疗方法，以改善脑瘫（CP）患者的步态和功能。尽管认识到肌肉无力是CP的重大损害，但这些治疗方法都没有直接的目的是增强肌肉。我们来自NIH研究的结果（R01-NS035830）表明脚踝强度和功能之间的相关性很高，强度更高与较高的功能相关。加强肌肉的想法在安全问题上引起了争议。该试点调查的目的是：1）为未来的随机临床试验建立样本量，以确定强化脚踝力量训练计划是否可以改善强度，步态和功能而不会增加痉挛性； 2）调查培训计划引起的潜在安全问题。目标1：为未来的随机临床试验建立样本量，以确定强化脚踝力量训练计划是否可以改善脚踝强度，步态和功能而不会增加痉挛性。二十名具有痉挛性diplygia cp的门诊受试者将随机分配给4组之一：1）背部反射力强度训练组； 2）足底反射力量训练小组； 3）背反射力力量训练组； 4）该小组没有接受强化力量训练计划。力量训练小组中的受试者将参加为期12周的进步，抵抗力量训练计划。在培训计划结束之前，将对所有受试者进行客观评估，以评估脚踝plant骨痉挛，脚踝强度，步态和GMFM。数据将用于重复测量功率分析，以建立临床试验的样本量。目标2：调查培训计划引起的潜在安全问题。目标有2个组件。首先是每周测量足底反射痉挛和紧密度。这些数据将允许对痉挛和紧密性进行持续监测，并提醒研究人员对每个受试者参与期间的潜在问题。在第二部分中，干预前和后的措施以及每周对痉挛和紧密度的监测，都将确定潜在的变化是否可能是未来临床试验的关注。