Motor Control Measures at the Ankle in CP

脑瘫患者踝部的运动控制措施

• 批准号: 6679021
• 负责人: DAVID R COLLINS
• 金额: $ 7.48万
• 依托单位: BARNES-JEWISH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6679021
• 关键词: ankle; behavioral /social science research tag; cerebral palsy; clinical research; data collection methodology /evaluation; functional ability; gait; human subject; joint disorder; mathematical model; muscle function; muscle strength; neuroregulation; spastic paralysis

DESCRIPTION (provided by applicant): Relative phase (a quantification of the relative timing between a pair of oscillators at the same frequency) has been used extensively in the able-bodied (AB) population to measure motor control (Collins et al., 1998), but never in cerebral palsy (CP). The purposes of this pilot investigation are to develop relative phase as a measure of motor control at the ankle for persons with CP, and relate the motor control measure to spasticity, strength, and function. Aim 1 is to develop a measure of motor control for the ankle dorsi/plantarflexors in persons with CP. Fifteen subjects with CP (CP group) and 15 with able bodies (AB group) will perform three movement tasks (1) move one (then the other) ankle to maximum dorsiplantarflexion in time with a pair of metronome beeps, (2) synchronize (i.e., in phase) their ankle movements, and (3) dorsiflex one ankle while plantarflexing the other and vice versa (i.e., antiphase). The tasks will be recorded using a motion capture system. Relative phase will be calculated between the ankle and the metronome or between the ankles. A mixed-design ANOVA will be used on the standard deviation of the relative phase measures to determine if differences exist between the CP and AB groups, and between tasks. The variability in the three relative phase tasks is expected to be less for the AB group compared to the CP group. It is hypothesized that the group differences will increase with task difficulty. Aim 2 will correlate the motor control measure with spasticity, strength, and function. The motor control measure from Aim 1 will be used with other tests to assess additional CP and AB groups (n=12 subjects/group). Subjects will be tested for motor control, spasticity, and strength, gait, gross motor function measure [GMFM]. Multiple regression will quantify relationships among the measures. The PIs hypothesize that the motor control measure will add to the amount of function variability explained by spasticity and strength. Upon completion, they will have data to initiate a more extensive study to quantify relationships between impairment measures and function.

描述（由申请人提供）：相对相位（一对相同频率的振荡器之间的相对定时的量化）已广泛用于健全 (AB) 人群来测量运动控制（Collins 等人，1998） ），但绝不会用于脑瘫（CP）。该试点研究的目的是开发相对相位作为脑瘫患者踝部运动控制的衡量标准，并将运动控制衡量标准与痉挛、力量和功能联系起来。 目标 1 是开发一种针对 CP 患者踝背/跖屈肌运动控制的方法。 15 名 CP 受试者（CP 组）和 15 名身体健全者（AB 组）将执行三项运动任务（1）随着两声节拍器蜂鸣声及时将一个（然后是另一个）脚踝移动到最大背屈，（2）同步（ (即，同相)他们的踝关节运动，以及 (3) 一个踝关节背屈，同时跖屈另一个踝关节，反之亦然(即，反相)。这些任务将使用动作捕捉系统进行记录。将计算脚踝和节拍器之间或脚踝之间的相对相位。混合设计方差分析将用于相对相位测量的标准偏差，以确定 CP 组和 AB 组之间以及任务之间是否存在差异。与 CP 组相比，AB 组的三个相对阶段任务的变异性预计较小。假设小组差异会随着任务难度的增加而增加。目标 2 将运动控制测量与痉挛、力量和功能相关联。目标 1 的运动控制测量将与其他测试一起使用，以评估其他 CP 和 AB 组（n=12 名受试者/组）。将测试受试者的运动控制、痉挛、力量、步态、粗大运动功能测量 [GMFM]。多元回归将量化测量之间的关系。 PI 假设运动控制措施将增加由痉挛和力量解释的功能变异量。完成后，他们将获得数据来启动更广泛的研究，以量化损伤测量和功能之间的关系。