Effect of Drug Use on the Legs: CVI, Mobility and Pain

吸毒对腿部的影响：CVI、活动能力和疼痛

• 批准号: 6852247
• 负责人: BARBARA A PIEPER
• 金额: $ 34.88万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6852247
• 关键词: amphetamines; ankle; behavioral /social science research tag; clinical research; cocaine; disease /disorder etiology; disease /disorder onset; disease /disorder proneness /risk; early diagnosis; foot; heroin; human middle age (35-64); human subject; intravenous drug abuse; leg; mathematical model; methadone; microcirculation; neuromuscular disorder; pain; peripheral blood vessel disorder; questionnaires; skin ulcer; venous thrombosis; young adult human (21-34)

DESCRIPTION (provided by applicant): The purpose of this study is to examine the adverse effects of illicit drug use on the legs, namely, early-onset chronic venous insufficiency (CVI), loss of mobility, and leg pain. Ranging from minor skin changes to leg ulcers that are difficult to heal, CVI is associated with restricted functioning, pain and suffering. Even persons who have stopped injecting drugs remain at risk. Our preliminary research indicates that this is a major health problem among those who have used injection drugs occurring with a prevalence of 87% in a large methadone clinic sample. The central hypotheses are that (a) the high prevalence of early onset CVI is a consequence of venous damage in the lower extremities due to injection drugs and (b) leg pain and the ensuing reduction in mobility further exacerbate the disease. Two specific aims will be addressed: (a) establish that injection use is responsible for early onset CVI and determine what other drug use variables moderate this effect, and (b) determine how ankle and general mobility and leg pain are associated with early onset CVI. This is an observation/comparative design. Clients (N=600), 30 to 60 years of age, will be recruited from substance abuse treatment centers. Eligible participants will be stratified into 3 groups according to route/site of illicit drug use. Selective sampling and statistical controls will be used to increase comparability of groups. Objective and self-report measures of drug use, leg pain, mobility, and CVI will be obtained individually form each participant. Descriptive, inferential, and structural equation model building will be used. We will extend our prior research to show the conditions under which injection drug use is responsible for early-onset CVI. We will examine leg pain and mobility as potential modifiable links between injection drug use and CVI. This research is significant because it will aid in our understanding of the mechanism of CVI and support the development of evidenced-based programs to promote leg health for those who have used injected drugs.

描述（由申请人提供）：本研究的目的是检查非法药物使用对腿部的不良影响，即早发性慢性静脉功能不全（CVI）、活动能力丧失和腿部疼痛。从轻微的皮肤变化到难以愈合的腿部溃疡，CVI 与功能受限、疼痛和痛苦有关。即使已经停止注射毒品的人仍然面临风险。我们的初步研究表明，这是使用注射毒品的人中的一个主要健康问题，在美沙酮诊所的大型样本中，患病率为 87%。中心假设是：(a) 早发性 CVI 的高患病率是注射药物导致下肢静脉损伤的结果；(b) 腿部疼痛和随之而来的活动能力下降进一步加剧了该疾病。将解决两个具体目标：(a) 确定注射使用是导致早发性 CVI 的原因，并确定哪些其他药物使用变量可以调节这种影响，以及 (b) 确定踝关节和一般活动能力以及腿部疼痛与早发性 CVI 之间的关系。这是一个观察/比较设计。将从药物滥用治疗中心招募 30 至 60 岁的客户 (N=600)。符合资格的参与者将根据非法药物使用途径/地点分为 3 组。将使用选择性抽样和统计控制来增加组的可比性。每位参与者将分别获得有关药物使用、腿部疼痛、活动能力和 CVI 的客观和自我报告的测量结果。将使用描述性、推理性和结构方程模型构建。我们将扩展之前的研究，以揭示注射药物使用导致早发 CVI 的条件。我们将研究腿部疼痛和活动能力作为注射吸毒和 CVI 之间潜在的可改变的联系。这项研究意义重大，因为它将有助于我们了解 CVI 的机制，并支持开发基于证据的计划，以促进注射吸毒者的腿部健康。