Biobehavioral Characterization of Infant Rhesus Monkeys

幼年恒河猴的生物行为特征

• 批准号: 6808109
• 负责人: JOHN P CAPITANIO
• 金额: $ 26.84万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-10 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6808109
• 关键词: Macaca mulatta; aggression; animal care; animal colony; animal developmental psychology; animal ecology; behavioral /social science research tag; behavioral genetics; chronic disease /disorder; diarrhea; environmental adaptation; ethology; genetic polymorphism; genotype; immunology; infant animal; longitudinal animal study; neuroendocrine system; personality; psychobiology; self destructive behavior; serotonin transporter; social psychology; stress

DESCRIPTION (provided by applicant): As the demand for laboratory-bred rhesus monkeys increases, it becomes crucial to manage our populations more effectively in an effort to optimize physical and psychological health, and ultimately production of sufficient numbers of high-quality animals for research purposes. At all primate facilities, there Ire animals that display poor health outcomes (eg, chronic diarrhea), and impaired behavioral, social, and reproductive outcomes (e.g., stereotypes, self-biting, poor social adaptation, poor maternal behavior), while other animals display none of these problems. What accounts for such individual variation? Two decades of psychobiological research with rhesus macaques have documented the existence of stable individual differences in the organization of behavior and physiology. These differences in biobehavioral organization arise from a number of sources, are detectable at an early age, and can persist throughout life. We propose that individual differences in biobehavioral organization (temperament, stress reactivity, personality) are an important contributor to variability in adaptation that is seen in primate colonies. At the CNPRC, we have successfully implemented a colony-wide assessment program based on this body of research. In the current proposal, we aim to continue this program, and to follow-up on the animals that have been enrolled in the program since 2001 by correlating our infancy measures with measures relating to psychological and physical health that are associated with colony management procedures such as relocations, group formations and indoor pairing. The goal of this analysis is to identify risk factors for negative outcomes and to use this information prospectively in colony management. Information on biobehavioral organization will also be made available to investigators who may wish to select animals with specific, defined characteristics for their research projects. Finally, an important aim is to identify more easily obtainable measures that personnel at other primate facilities might adopt that retain the predictive power of the to-be-identified risk factors identified by our more elaborate assessment program. Quantitative application of the solid research base in nonhuman primate psychobiology to colony management is a novel and innovative aspect of this proposal, and reflects a unique blending of goals between colony management and psychobiological science that is, we believe, unique in the NPRC system.

描述（由申请人提供）：随着对实验室饲养的恒河猴的需求增加，更有效地管理我们的种群以优化身心健康并最终生产足够数量的高质量动物用于研究变得至关重要目的。在所有灵长类动物设施中，都有一些动物表现出健康状况不佳（例如慢性腹泻）以及行为、社会和生殖结果受损（例如刻板印象、自咬、社会适应能力差、母性行为差），而其他动物显示没有这些问题。是什么导致了这种个体差异？二十年来对恒河猴的心理生物学研究证明了行为和生理组织中存在稳定的个体差异。生物行为组织的这些差异有多种来源，可以在很小的时候就被发现，并且可以持续一生。我们认为，生物行为组织（气质、应激反应性、个性）的个体差异是灵长类群体适应变化的重要因素。在 CNPRC，我们基于这一研究成果成功实施了整个群体的评估计划。在当前的提案中，我们的目标是继续该计划，并通过将我们的婴儿期测量值与与群体管理程序相关的心理和身体健康测量值关联起来，对自 2001 年以来加入该计划的动物进行跟踪。例如重新安置、分组和室内结对。该分析的目的是确定负面结果的风险因素，并在群体管理中前瞻性地使用这些信息。有关生物行为组织的信息也将提供给可能希望为其研究项目选择具有特定、明确特征的动物的研究人员。最后，一个重要的目标是确定其他灵长类动物设施的人员可能采取的更容易获得的措施，这些措施保留了我们更详细的评估计划确定的待识别风险因素的预测能力。将非人类灵长类心理生物学的坚实研究基础定量应用于群体管理是该提案的新颖和创新方面，反映了群体管理和心理生物学之间目标的独特融合，我们相信，这在 NPRC 系统中是独一无二的。