SELF INJURIOUS BEHAVIOR AND PRIMATE WELL BEING

自残行为与灵长类动物的健康

• 批准号: 6078281
• 负责人: Melinda Ann Novak
• 金额: $ 24.92万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2000-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6078281
• 关键词: Macaca mulatta; aggression; animal care; animal colony; animal population study; animal welfare research; blood chemistry; data collection; disease /disorder proneness /risk; ethology; neurotransmitters; self destructive behavior

Successful management of laboratory monkey colonies requires a substantial investment of personnel as well as adequate facilities. The ultimate goal of colony management is to maintain the highest standards of health and well-being across all the monkeys in a given facility within the context of the research program. Despite the strides made in controlling colony diseases, in developing new housing procedures, and in modernizing facilities, some monkeys show abnormal behavior. Of particular concern is the small, but persistent percentage of monkeys that become self-aggressive and develop the syndrome of SIB. Although many causes have been suggested, none seem to explain why only a small percentage of monkeys is affected. The overall objective of this project is to characterize the nature of SIB in rhesus monkeys, and to identify the mechanisms responsible for the expression of these behavior patterns. The investigators will determine whether physical health or colony management practices differ between SIB and control monkeys, and will use archival procedures to ensure a sufficient number of subjects. The remainder of the work is focused on behavioral, biochemical, and pharmacological studies of a group of SIB and control monkeys. An evaluation will be made of the structure of SIB, its relationship to other behavior patterns, the context in which it occurs, and diurnal variation in SIB in order to identify stimuli in the environment that appear to provoke it. As part of this project, three risk factors will be examined that may have some association to SIB: hyperactivity, impulsive aggression, and arthritic disorders. The presence of such risk factors will be tested experimentally. Neurotransmitter correlates of these risk factors as well as the efficacy of drugs that may reduce SIB will be sought. Such a multilevel analysis will enable a characterization of this disorder, and will assist in determining what risk factors might predispose some monkeys to develop the syndrome. This information is critical for developing effective interventions and improving colony management.

成功管理实验室猴子殖民地需要 大量投资人员和足够的设施。 殖民地管理的最终目标是保持最高 给定的所有猴子的健康和福祉标准 在研究计划的背景下的设施。 尽管有 在控制菌落疾病的方面取得了长足的进步，开发新住房 程序和现代化设施时，一些猴子表现出异常 行为。 特别关心的是很小但持久的 成为自我攻击并发展的猴子的百分比 SIB综合征。 尽管已经提出了许多原因，但似乎没有 解释为什么只有一小部分猴子受到影响。 这 该项目的总体目的是表征SIB的性质 在恒河猴中，并确定负责 这些行为模式的表达。 调查人员会 确定身体健康或殖民管理实践是否有所不同 在SIB和控制猴子之间，将使用档案程序 确保足够数量的受试者。 其余的工作是 专注于行为，生化和药理学研究 一组SIB和控制猴子。 将对 SIB的结构，其与其他行为模式的关系， 它发生的上下文以及SIB的昼夜变化 在似乎引起它的环境中识别刺激。 作为一部分 在该项目中，将检查三个可能有一些风险因素 与SIB的关联：多动症，冲动攻击和关节炎 疾病。 将测试此类风险因素的存在 实验。 神经递质将这些危险因素的相关性 随着可能会减少SIB的药物的功效。 这样的 多级分析将使这种疾病的特征， 并将有助于确定哪些风险因素可能使某些风险因素易于 猴子发展综合征。 此信息对于 制定有效的干预措施并改善殖民地管理。