ESTABLISHING PREDICTORS OF SIB IN RHESUS MONKEYS

建立恒河猴 SIB 的预测因子

• 批准号: 8357931
• 负责人: Melinda Ann Novak
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357931
• 关键词: Animal Model; Behavior; Behavior assessment; Biological Assay; Biological Markers; Clinical; Collaborations; Development; Disease; Funding; Genetic Variation; Grant; Hair; Housing; Human; Hydrocortisone; Longitudinal Studies; Macaca; Macaca mulatta; Monkeys; National Center for Research Resources; National Institute of Child Health and Human Development; New England; Opioid; Population; Prevention strategy; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Risk Factors; Saliva; Sampling; Screening procedure; Source; Syndrome; United States National Institutes of Health; base; biological adaptation to stress; cohort; cost; male; novel; stereotypy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have previously established an animal model of naturally occurring SIB in which monkeys show a reduced stress response and lower opioid levels compared to controls. Because we study monkeys only after they have spontaneously developed SIB, we do not know whether these differences are risk factors for or consequences of developing SIB. The purpose of this project is to determine whether there are early markers for the onset of SIB and stereotypic behavior. We are currently conducting a unique, large-scale longitudinal study of a cohort of male monkeys in which we are coordinating our standard behavioral assessments of abnormal behavior, collecting hair and saliva samples for cortisol and other assays, and searching for polymorphic gene variants that are predictive of later SIB or stereotypy development. We are also examining hair cortisol profiles in macaques as a function of housing, early rearing, and species (in collaboration with Dr. Stephen Suomi, NICHD). The determination of biomarkers for these syndromes can then be used for colony screening and the development of new prevention strategies. Elucidation of novel biomarkers of SIB will also have significant implications for our understanding of this disorder in human clinical populations.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 我们以前已经建立了一种天然发生的SIB动物模型，与对照组相比，猴子表现出降低的应力反应和降低的阿片类药物水平。 因为我们只有在自发发展SIB后才研究它们，所以我们不知道这些差异是发展SIB的风险因素还是后果。 该项目的目的是确定SIB和刻板印象的发作是否有早期标记。 目前，我们正在对一系列雄性猴子进行独特的大规模纵向研究，其中我们正在协调对异常行为的标准行为评估，收集头发和唾液样品，用于皮质醇和其他测定法，并搜索多型基因变种，以预测后来的SIB SIB或STEREREPY型开发。 我们还正在检查猕猴中的皮质蛋白酶剖面，这是住房，早期饲养和物种的函数（与NICHD的Stephen Suomi博士合作）。 然后，可以将这些综合征生物标志物的确定用于菌落筛查和新预防策略的发展。 阐明新型SIB的生物标志物也将对我们在人类临床人群中对这种疾病的理解产生重大影响。