EFFECTS OF SHAMPOO AND WATER WASHING ON HAIR CORTISOL CONCENTRATIONS

洗发水和水洗对头发皮质醇浓度的影响

• 批准号: 8358018
• 负责人: Melinda Ann Novak
• 金额: $ 5.4万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8358018
• 关键词: Biological Markers; Chronic stress; Elements; Exposure to; Funding; Grant; Hair; Hair shaft structure; Housing; Human; Hydrocortisone; In Vitro; Laboratories; Macaca mulatta; Measurement; Monkeys; National Center for Research Resources; Nature; Neck; New England; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Source; Testing; United States National Institutes of Health; Water; base; cost; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Measurement of cortisol in hair is emerging as a biomarker for chronic stress in human and nonhuman primates. Because of its external nature, hair is potentially vulnerable to a loss of cortisol from within the hair shaft due to repeated exposure to various substances such as shampoo (in humans) and water (in free-ranging monkeys). This study examined the influence of both factors on the hair cortisol levels of indoor laboratory housed rhesus monkeys. The effect of shampoo and water cannot be tested in humans because of the need to have hair that had no prior exposure to these elements. Hair was shampooed and exposed to water in vitro (i.e., after it had been gently shaved from the nape of the neck of the rhesus monkeys).

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 头发中皮质醇的测量正在成为人类和非人类灵长类动物中慢性应激的生物标志物。由于其外部性质，由于反复暴露于洗发水（人类）和水（在自由放映的猴子中），头发可能容易受到从脱发内部的皮质醇损失的影响。 这项研究检查了这两种因素对室内实验室恒河猴的头发皮质醇水平的影响。 洗发水和水的影响无法在人类中进行测试，因为有必要先前暴露于这些元素的头发。 头发被洗头并在体外暴露于水中（即，从恒河猴的脖子上轻轻剃光后）。