Biobehavioral characterization of infant rhesus monkeys

幼年恒河猴的生物行为特征

• 批准号: 9251921
• 负责人: JOHN P CAPITANIO
• 金额: $ 36万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9251921
• 关键词: Adopted; Affect; Age; Animals; Applications Grants; Behavior; Behavioral; Biological Markers; C-reactive protein; California; Characteristics; Chronic; Communities; Data; Data Set; Databases; Decision Making; Development; Diarrhea; Disease; Educational workshop; Emotional; Funding; Genes; Genetic; Genetic Polymorphism; Genotype; Health; Hour; Human; Hypothalamic structure; Individual; Infant; Inflammation; Institution; Knowledge; Life; Life Experience; Literature; Macaca mulatta; Measurable; Measures; Memory; Mental Health; Modeling; Monoamine Oxidase A; Motor; Organism; Outcome; Pattern; Peer Review; Performance; Personality; Physiological; Pituitary-Adrenal System; Primates; Principal Investigator; Procedures; Promoter Regions; Protocols documentation; Publishing; Regulation; Research; Resources; Review Literature; Risk; Risk Factors; Rodent; Scientist; Standardization; Subjects Selections; System; Temperament; Time; Training and Education; United States; Variant; behavioral outcome; biobehavior; coping; data resource; design; experience; improved; microbial; model development; neuropsychiatry; nonhuman primate; novel; online resource; outreach; personalized approach; personalized medicine; physical conditioning; prenatal; primate development; programs; promoter; public health relevance; reproductive; serotonin transporter; social; stereotypy; web page; willingness

DESCRIPTION (provided by applicant): From an early age, organisms display variation in patterns of behavioral and physiological reactivity, temperament, emotionality, and personality, a set of overlapping constructs referred to as "biobehavioral organization." These patterns appear early in life and are remarkably stable over time. A growing literature, has focused on the origins of this variation as well as its consequences for a variety of health outcomes. Such an individualized approach is evident in development of the field of personalized medicine, and this approach is becoming increasingly adopted in more applied settings as well, including in the management of captive nonhuman primates. At the California National Primate Research Center we have developed a BioBehavioral Assessment (BBA) Program to characterize biobehavioral organization in infant rhesus monkeys. The BBA Program involves a highly standardized, 25-hour-long, protocol that includes a) collecting behavioral data to assess memory, responsiveness to mild challenges, and willingness to interact with novel objects; b) genotyping for polymorphisms in the promoter regions of the serotonin transporter and monoamine oxidase-A genes; c) assessing regulation of the hypothalamic-pituitary-adrenal system; and d) measuring routine hematologic parameters. In addition to providing a database for scientific studies, the BBA Program contributes to the knowledge and improvement of the nonhuman primate resource at our own center, and published studies provide important information to management staff at other primate facilities in the United States as well. The following four specific aims are proposed: 1. Continue performing the BioBehavioral Assessment, and make these data available to management staff at CNPRC and qualified scientific staff at CNPRC and other institutions; 2. Incorporate into the BBA program a biomarker of inflammation, namely C-reactive protein, and examine the relationship between this marker and other BBA measures, as well as health outcomes; 3. Continue to examine causes and consequences of variation in BBA measures to better understand how biobehavioral organization is affected by management procedures, and to determine whether biobehavioral organization predicts abnormal behavior outcomes; 4. Improve dissemination of important colony management-related findings via both inreach efforts (focusing on education and training of individuals at CNPRC), and outreach efforts (for the larger nonhuman primate behavior management community).

描述（由申请人提供）：从很小的时候开始，有机体表现出行为和生理反应性，气质，情感和个性的模式的差异，这是一组重叠的构造，称为“生物行为组织”。这些模式出现在生命的早期，并且随着时间的流逝非常稳定。越来越多的文献集中在这种变化的起源以及对各种健康结果的后果上。这种个性化的方法在个性化医学领域的发展中很明显，这种方法也越来越多地在应用的环境中采用，包括在圈养非人类灵长类动物的管理中。在加利福尼亚国家灵长类动物研究中心，我们开发了一项生物行为评估（BBA）计划，以表征婴儿恒河猴的生物行为组织。 BBA计划涉及一个高度标准化的25小时的协议，其中包括a）收集行为数据以评估记忆，对轻度挑战的响应以及愿意与新物体互动； b）在5-羟色胺转运蛋白和单胺氧化酶-A基因的启动子区域中多态性的基因分型； c）评估下丘脑 - 垂体 - 肾上腺系统的调节； d）测量常规血液学参数。除了提供科学研究数据库外，BBA计划还为我们自己中心的非人类灵长类动物资源的知识和改进做出了贡献，并且已发表的研究也向美国其他灵长类动物设施的管理人员提供了重要信息。提出了以下四个特定目标：1。继续进行生物行为评估，并将这些数据提供给CNPRC的管理人员以及CNPRC和其他机构的合格科学人员； 2。将炎症的生物标志物纳入BBA计划，即C反应蛋白，并检查该标记物与其他BBA措施之间的关系以及健康结果； 3。继续检查BBA措施变化的原因和后果，以更好地了解生物行为组织如何受到管理程序的影响，并确定生物行为组织是否预测了异常行为结果； 4.通过INREACH努力（专注于CNPRC的个人的教育和培训）和外展工作（对于更大的非人类灵长类动物行为管理社区），改善与殖民地管理相关的重要发现的传播。