Imaging ESS for in-vivo detection of cancer

用于癌症体内检测的成像 ESS

• 批准号: 6783810
• 负责人: ELLIOT S WACHMAN
• 金额: $ 10万
• 依托单位: CHROMODYNAMICS, INC. (CDI)
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6783810
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biopsy; clinical biomedical equipment; diagnosis design /evaluation; early diagnosis; electron optics; gastrointestinal imaging /visualization; image enhancement; image guided surgery /therapy; light scattering; neoplasm /cancer diagnosis; optical polarization; phantom model; spectrometry; time resolved data

DESCRIPTION (provided by applicant): Detecting cancer early is critical to successful treatment. Within the last decade, a number of minimally invasive techniques for identifying pre-malignant tissue have been developed to address this issue. One of the most promising is elastic scattering spectroscopy (ESS), an "optical biopsy" technique that has demonstrated the capability of detecting abnormal lesions in a variety of organ systems. To date, this technique has been used in-vivo only with a pointdetection probe. In this proposal, a second-generation device for performing imaging elastic scattering spectroscopy 0ESS) is presented. The goal of this Phase I proposal is to fabricate a clinically-ready lESS system, and demonstrate that it can reliably quantitate scatterer size in tissue phantoms. Phase II will concentrate on clinical translational studies of this system, and will begin with a study of its use for detection of dysplasia in Barrett's esophagus. As part of the present proposal, an approved protocol for this initial trial will be developed.

描述（由申请人提供）： 早期检测癌症对于成功治疗至关重要。在过去的十年中，已经开发了许多用于识别机场前组织的微创技术来解决这个问题。最有前途的是弹性散射光谱（ESS），这是一种“光学活检”技术，它证明了在各种器官系统中检测异常病变的能力。迄今为止，该技术仅在Vivo中使用了点进行探针。在此提案中，提出了用于执行成像弹性散射光谱0ESS的第二代设备。该阶段I建议的目的是制造一个临床准备就绪的系统，并证明它可以可靠地量化组织幻像中的散射器大小。第二阶段将集中于该系统的临床翻译研究，并将开始研究其用于检测Barrett食管中发育不良的使用。作为本提案的一部分，将制定该初步审判的批准协议。