Optical Coherence Microscopy for Endoscopic Diagnostics

用于内窥镜诊断的光学相干显微镜

• 批准号: 7062332
• 负责人: AARON D AGUIRRE
• 金额: $ 4.43万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-16 至 2009-01-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7062332
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biopsy; cell morphology; clinical research; confocal scanning microscopy; endoscopy; gastrointestinal imaging /visualization; gastrointestinal neoplasms; human subject; laboratory rabbit; miniature biomedical equipment; molecular /cellular imaging; neoplasm /cancer diagnosis; optical tomography; predoctoral investigator; preneoplastic state; surgery material /equipment; technology /technique development

DESCRIPTION (provided by applicant): The hypothesis of this proposal is that optical coherence microscopy (OCM), a combination of OCT with confocal microscopy, can enable cellular resolution endoscopic imaging of tissue morphology, thereby dramatically advancing the capabilities of either technique for endoscopic detection of early stage neoplasms. An endoscopic "optical biopsy" technique that allows for real time, in vivo imaging of precancerous changes at the cellular level would allow image guidance of traditional excisional biopsy, potentially reducing sampling error and improving sensitivity. The specific aims are: 1) Develop optical coherence microscopy (OCM) technology for cellular imaging of unstained tissues. 2) Investigate OCM for detecting early neoplastic cellular alterations in human tissues through ex vivo clinical imaging studies. 3) Develop miniaturized flexible endoscopes for OCM imaging based on micro-electro-mechanical systems (MEMS) scanning technology. 4) Validate flexible OCM endoscopes through in vivo animal imaging experiments. These studies combined seek to demonstrate fundamental new advances for endoscopic detection of early stage neoplasms.

描述（由申请人提供）：该提案的假设是光学相干显微镜（OCM）（OCT与共焦显微镜的组合）可以实现组织形态的细胞分辨率内窥镜成像，从而显着提高任一技术的内窥镜检测能力早期肿瘤。内窥镜“光学活检”技术可以在细胞水平上对癌前变化进行实时体内成像，从而可以对传统切除活检进行图像引导，从而有可能减少采样误差并提高灵敏度。具体目标是：1）开发用于未染色组织细胞成像的光学相干显微镜（OCM）技术。 2) 研究OCM，通过离体临床成像研究检测人体组织中的早期肿瘤细胞改变。 3）开发基于微机电系统（MEMS）扫描技术的用于OCM成像的小型化柔性内窥镜。 4) 通过体内动物成像实验验证柔性 OCM 内窥镜。这些研究相结合，旨在证明早期肿瘤内窥镜检测的基本新进展。