OCT Image-guided Biopsy Needle

OCT 图像引导活检针

• 批准号: 6963474
• 负责人: Xingde Li
• 金额: $ 19.15万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6963474
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biopsy; fine needle aspiration; image guided surgery /therapy; laboratory mouse; optical tomography; prostate neoplasms

DESCRIPTION (provided by applicant): This proposal is a collaborative, multidisciplinary program involving researchers from the College of Engineering, School of Medicine at the University of Washington and the Clinical Research Division at the Fred Hutchinson Cancer Research Center. The objective is to develop a high-quality fiber-optic imaging needle that can be integrated with a biopsy needle for in situ guidance of tissue sampling. New methods will be explored to control and achieve desired imaging beam parameters, and to simplify the microfabrication process. The imaging needle is not intended to replace the conventional needle biopsy and histology, but rather to optimize tissue sampling by directing the biopsy to areas of highest yield. Cancers develop over a period of several years and they are characterized by changes in tissue and cellular structure and tissue optical properties. Biopsy followed by histology is the current standard for cancer diagnosis. The major challenge with the gold standard is that biopsies can have low sensitivity due to sampling error. It remains challenging to target the biopsy needle to a small lesion or the most malignant tissue of a large lesion even under conventional image-guidance. Optical coherence tomography (OCT) is an emerging technology that can perform in vivo cross-sectional imaging of tissue microanatomy in real time. In addition, quantitative information about localized tissue optical properties can also be obtained with OCT. The hypothesis of this proposal is that a robust, miniature OCT imaging needle which provides high-resolution tissue microanatomy and quantitative localized tissue optical properties, can be developed and integrated within a biopsy needle for guiding biopsy in situ. The specific aims are to: (1) develop a miniature imaging needle using new engineering methods to achieve high optical quality and mechanical robustness; (2) integrate the imaging needle with a biopsy needle and test the performance of the integrated device with tissue phantoms; and (3) explore the feasibility of the integrated device for guiding biopsy in the mouse prostate cancer TRAMP model in vivo. If successful, the functionally integrated biopsy device can benefit tumor diagnosis in solid organs such as the breast, prostate and pancreas by reducing random sampling errors, minimizing the required sampling tissue volume and the total number of biopsies, and making biopsy less invasive.

描述（由申请人提供）：该提案是一项合作，多学科的计划，涉及工程学院，华盛顿大学医学院和弗雷德·哈钦森癌症研究中心的临床研究部。目的是开发高质量的纤维化成像针，该针头可以与活检针对组织采样的原位指导进行集成。将探讨新方法以控制和实现所需的成像光束参数，并简化微加工过程。成像针并非旨在替代常规的针头活检和组织学，而是通过将活检引导到最高产量区域来优化组织采样。癌症在几年的时间内发展，它们的特征是组织，细胞结构以及组织光学特性的变化。活检后进行了组织学是当前的癌症诊断标准。黄金标准的主要挑战是，由于采样误差，活检可能具有低灵敏度。即使在常规的图像指导下，将活检针靶向小病变或最恶性组织的小病变或最恶性组织仍然具有挑战性。光学相干断层扫描（OCT）是一种新兴技术，可以实时对组织微型解剖学进行体内横截面成像。另外，还可以通过OCT获得有关局部组织光学特性的定量信息。该提议的假设是，可以在活检针中开发并整合了可提供高分辨率组织微分析和定量局部组织光学特性的坚固，微型OCT成像针，可用于指导原位活检。具体目的是：（1）使用新的工程方法开发微型成像针，以实现高光学质量和机械鲁棒性； （2）将成像针与活检针头整合，并用组织幻像测试集成装置的性能； （3）探索在体内小鼠前列腺癌潮流模型中引导活检的集成装置的可行性。如果成功，功能整合的活检装置可以通过减少随机采样误差，最大程度地减少所需的采样组织体积和活检的总数，从而使乳房，前列腺和胰腺等固体器官（例如乳房，前列腺和胰腺）中有益于肿瘤诊断，并使活检减少侵入性。