Alteration and Renovation

改建和翻新

• 批准号: 8812380
• 负责人: THOMAS EDWARD PRISINZANO
• 金额: $ 9.28万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8812380
• 关键词: Biological; Biological Assay; Biology; Chemicals; Communicable Diseases; Containment; Equipment; Funding; Housing; Infectious Agent; Kansas; Laboratories; Location; Research; Screening procedure; Time; Universities; Validation; assay development; hazard; high throughput screening; screening; small molecule libraries; square foot; structural biology

Project Summary Effective and efficient high-throughput screening (HTS) of large chemical libraries requires many carefully coordinated efforts that span target selection through assay validation and into automated large-scale screening. Additionally, assay development and performing high-throughput screening for infectious disease targets can often require special consideration and conditions due to biological hazard and containment issues. To provide for these special considerations and minimize the impact of infectious agents on the general activities of the HTS facility and associated equipment, we propose to renovate space adjacent to the high- throughput screening facility such that it is suitable for performing infectious disease assay development and limited chemical screening associated with Core B. The proposed renovations would provide 211 sq ft of laboratory space dedicated for infectious disease assay development and many high-throughput screening procedures. The proposed laboratory would be suitably equipped through direct contributions from the University of Kansas. Timing for renovations to be completed are estimated to be within six months after receipt of funds.

项目概要 对大型化学文库进行有效且高效的高通量筛选 (HTS) 需要许多仔细的工作 协调一致的努力，涵盖目标选择、分析验证和自动化大规模 筛选。此外，还开展传染病的检测开发和高通量筛选 由于生物危害和遏制问题，目标通常需要特殊考虑和条件。 考虑到这些特殊因素并尽量减少传染源对总体的影响 HTS 设施和相关设备的活动，我们建议翻新毗邻高 通量筛选设施，适合进行传染病检测开发和 与核心 B 相关的有限化学筛选。拟议的翻修将提供 211 平方英尺的 实验室空间专用于传染病检测开发和许多高通量筛选 程序。拟议的实验室将通过直接捐助来配备适当的设备 堪萨斯大学。预计翻修工程将于竣工后六个月内完成 收到资金。