NEURAL CONTROL OF VISUAL-VESTIBULAR BEHAVIOR

视觉前庭行为的神经控制

• 批准号: 6754473
• 负责人: Michael J Mustari
• 金额: $ 40万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-07 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6754473
• 关键词: Macaca mulatta; behavior test; behavioral /social science research tag; eye movements; mesencephalon; neural plasticity; neurophysiology; neuroregulation; optic tract; sensorimotor system; single cell analysis; tegmentum; vestibular apparatus; vestibular pathway; visual perception

DESCRIPTION (Provided by applicant): Norma1 posture, balance and stable vision are dependent on interactions between the visual and vestibular systems. Our studies are directed at defining the neural substrate for normal visual-vestibular-oculomotor behavior. There is a continuous need to calibrate the motor output of the vestibular ocular reflex due to normal development or injury to the vestibular system. Without this calibration, difficulties in maintaining balance and clear vision during locomotion would occur. In addition to long-term calibration, vision is supported by moment-by-moment or dynamic visual-vestibular interactions. The neural structures involved in processing visual motion information for vestibular function are incompletely understood. Our earlier studies have shown that the pretectal nucleus of the optic tract (NOT) and the dorsolateral pontine nucleus (DLPN) receive visual information from different central structures and play a critical role in visualoculomotor behavior. Furthermore, the NOT and DLPN have efferent connections with the vestibulocerebellum and vestibular nuclei, structures known to play a role in visual-vestibular function per se. Our neurophysiological studies will define the contributions made by these important visual afferent sources to vestibular function and sensorimotor integration. Completion of our studies will be of benefit in the diagnosis and treatment of disorders of vision, balance and posture associated with vestibular dysfunction.

描述（申请人提供）：Norma1姿势，平衡和稳定的视力 取决于视觉和前庭系统之间的相互作用。我们的 研究旨在定义正常的神经底物 视觉 - 卵巢核能行为。需要持续校准 由于正常发育或 前庭系统受伤。没有这种校准，困难 在移动过程中保持平衡和清晰的视力。此外 长期校准，视力受到时刻或动态的支持 视觉范围的相互作用。处理的神经结构 前庭功能的视觉运动信息尚不完全理解。 我们较早的研究表明，光学的预性核 （非）和背外侧丘脑核（DLPN）接收视觉信息 来自不同的中央结构，在Visualoculomotor中起关键作用 行为。此外，非和DLPN与 前庭脑和前庭核，已知在 视觉 - 视觉函数本身。我们的神经生理研究将定义 这些重要的视觉传入来源对前庭的贡献 功能和感觉运动积分。我们的学习完成将是 在诊断和治疗视力，平衡和治疗方面受益 与前庭功能障碍相关的姿势。