HABS-HD - Project 3

HABS-HD - 项目 3

• 批准号: 10708902
• 负责人: Sid E O'Bryant
• 金额: $ 52.41万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708902
• 关键词: Acculturation; African American population; Age of Onset; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer’s disease biomarker; Amyloid; Area; Autopsy; Biological; Biological Markers; Blood Vessels; Childhood; Cognition; Cognitive; Collaborations; Data; Disease; Disease Outcome; Disparate; Disparity; Epigenetic Process; Ethnic Population; Health; Health Disparities Research; Hispanic Populations; Household; Impaired cognition; Income; Inflammation; Inflammatory; Intervention; Language; Lead; Link; Magnetic Resonance Imaging; Measures; Memory; Metabolic; Metabolic dysfunction; Mexican Americans; Neighborhoods; Nerve Degeneration; Not Hispanic or Latino; Outcome; Pathologic; Plasma; Population Heterogeneity; Prevalence; Race; Research; Research Personnel; Risk; Stress; aging brain; burden of illness; cognitive function; deprivation; epigenetic marker; ethnic difference; executive function; experience; health disparity; indexing; magnetic resonance imaging biomarker; methylation pattern; middle age; neighborhood disadvantage; neuropathology; racial difference; racial population; racism; residential segregation; social culture; social factors; sociocultural determinant; successful intervention; tau Proteins; theories; trend

HABS-HD PROJECT 3 ABSTRACT African Americans (AAs) currently suffer the highest burden of Alzheimer’s disease (AD) and Alzheimer’s Disease-Related Dementias (ADRD) while Hispanics (65% of which are Mexican American [MA]) will experience the greatest increase in disease burden by 2060. Additionally, emerging data supports racial/ethnic differences in the fundamental pathological biomarkers of Amyloid (A), Tau (T), and Neurodegeneration (N) in AD, as defined by the 2018 AT(N) framework (Project 1). Research also demonstrates a significant impact of vascular, metabolic and inflammatory (VMI) factors on AD outcomes, which are experienced at higher rates among AAs and MAs and, therefore, may impact AT(N) biomarkers (Project 2). Given that AAs and MAs experience a disparate burden of exposome and sociocultural factors previously linked to AD outcomes, these factors may contribute to observed AD health disparities and biomarker differences. In fact, the Link & Phelan “Fundamental Causes Theory” proposes that social factors may be ‘fundamental causes’ of disease and must be considered for successful intervention strategies. Milestones 1.B and 1.I of the NIA AD + ADRD Implementation Milestones explicitly call for examinations of the impact of exposome and social factors on AD/ADRD disparities. Therefore, Project 3 will evaluate the impact of exposome (i.e., neighborhood disadvantage) and sociocultural (i.e., acculturation, stress, perceived racism) factors on the prevalence, sequence and trajectories of cognitive decline as well as AT(N) defined biomarkers among the three largest racial/ethnic groups in the U.S. Therefore, Project 3 will address the following Specific Aims in alignment with the NIA Health Disparities Research Framework. Aim 1: Examine the link between neighborhood disadvantage and sociocultural factors on the presence and longitudinal progression of cognitive loss among African Americans, Mexican Americans and non-Hispanic whites. Aim 2: Examine the impact of neighborhood disadvantage and sociocultural factors on the presence, sequence and trajectories of AT(N) defined biomarkers among African Americans, Mexican Americans and non-Hispanic whites. Aim 3: Examine the impact of epigenetic factors on the link between neighborhood disadvantage and sociocultural factors on AT(N) defined biomarkers, and cognitive trajectories, among African Americans, Mexican Americans and non- Hispanic whites. Aim 4 (Project – Project Interactions): Collaborate with Projects 1 and 2 to develop a comprehensive understanding of AT(N) defined biomarkers across diverse populations. Aim 5: Utilize data from Project 3 as a comparison for other studies examining the impact of neighborhood disadvantage (e.g., Neighborhood Study), and sociocultural factors (e.g., WHICAP, SOL/INCA), on AD biomarkers and cognitive trajectories.

HABS-HD项目3摘要 非洲裔美国人（AAS）目前遭受阿尔茨海默氏病（AD）和阿尔茨海默氏症的最高烧伤 与疾病有关的痴呆症（ADRD），而西班牙裔（其中65％是墨西哥裔美国人[MA]）将 到2060年，伯恩（Burnen）的疾病增长最大。此外，新兴数据支持种族/族裔 淀粉样蛋白（a），tau（t）和神经变性（n）的基本病理生物标志物的差异 AD，如2018年（n）框架（项目1）所定义的。研究还证明了 AD结果的血管，代谢和炎症（VMI）因素，这些因素以较高的速度经历 因此，在AAS和MAS中，可能会影响（N）生物标志物（项目2）。鉴于AAS和MAS 经历了以前与广告结果相关的杂物体和社会文化因素的不同伯恩（Burnen） 因素可能导致观察到的AD健康差异和生物标志物差异。实际上，Link＆Phelan “基本原因是理论”的建议，即社会因素可能是疾病的'基本原因，必须是 考虑用于成功的干预策略。 NIA AD + ADRD的里程碑1.b和1.i 实施里程碑明确呼吁对宣传体和社会因素的影响进行检查 广告/ADRD差异。因此，项目3将评估展示体的影响（即邻里 劣势）和社会文化（即培养，压力，感知种族主义）因素 认知下降以及（n）定义的生物标志物的患病率，序列和轨迹 因此，美国三个最大的种族/族裔群体将解决以下特定的特定问题 目标与NIA健康差异研究框架保持一致。目标1：检查 认知能力的存在和纵向进步的邻里灾难和社会文化因素 非裔美国人，墨西哥裔美国人和非西班牙裔白人的损失。目标2：检查 邻里灾难和社会文化因素（AT）的存在，顺序和轨迹（n） 在非洲裔美国人，墨西哥裔美国人和非西班牙裔白人中定义的生物标志物。目标3：检查 表观遗传因素对邻里灾难与社会文化因素之间联系的影响 在非洲裔美国人，墨西哥裔美国人和非 - 西班牙裔白人。 AIM 4（项目 - 项目互动）：与项目1和2合作开发一个 对AT（N）定义的生物标志物的全面理解。目标5：利用数据 从项目3作为其他研究的比较，以研究邻里灾难的影响（例如， 邻里研究）和社会文化因素（例如WHICAP，SOL/INCA），关于AD生物标志物和认知能力 轨迹。