HABS-HD - Core E - Disparities & Outreach Core

HABS-HD - 核心 E - 差异

• 批准号: 10708877
• 负责人: Sid E O'Bryant
• 金额: $ 73.67万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708877
• 关键词: Address; African American population; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Awareness; Back; Biological Markers; Brain; Clinical; Cognitive aging; Collaborations; Communities; Community Networks; Community Outreach; Data; Development; Disparate; Disparity; Education; Education and Outreach; Educational Materials; Ensure; Ethnic Population; Event; Feedback; Focus Groups; Funding; Future; Goals; Health; Health Disparities Research; Hispanic Populations; Home; Individual; Informatics; Infrastructure; Institution; Life Cycle Stages; Linguistics; Location; Measures; Methods; Mexican Americans; Minority Groups; Monitor; Newsletter; Not Hispanic or Latino; Participant; Population; Population Heterogeneity; Prevention strategy; Procedures; Process; Protocols documentation; Publications; Race; Research; Research Methodology; Scientist; Spinal Puncture; Students; Training; Underrepresented Minority; Work; aged; aging brain; cohort; community engagement; ethnic minority population; health disparity; health goals; improved outcome; information gathering; member; multi-ethnic; neuroimaging; novel; outreach; precision medicine; racial minority population; racial population; recruit; social media; treatment strategy

HABS-HD DISPARITIES & OUTREACH CORE (CORE E) - ABSTRACT One of the primary goals of the National Alzheimer’s Project Act (NAPA) is to “improve outcomes for ethnic and racial minority populations.” However, substantial gaps in understanding the reasons for the disparate increase in Alzheimer’s disease (AD) and AD related disorders (ADRDs) in ethnic and racial minority populations exist, primarily due to the underrepresentation of minority groups in aging research. Community engagement and outreach is considered one of the most successful strategies to recruiting diverse populations into research. The Dallas Forth-Worth (DFW) metroplex, home to the Health and Aging Brain Study-Health Disparities (HABS-HD), is currently reflective of the future U.S. racial/ethnic population and an ideal location to simultaneously study cognitive aging among African Americans (AA), Mexican Americans (MA; 63% of the U.S. Hispanic population) and non-Hispanic whites (NHW). HABS-HD is the first large-scale, community-based project to simultaneously study each of the AT(N) defined biomarkers, in alignment with the NIA Health Disparities Research Framework. The long-term goal of HABS-HD is to establish population-specific informed precision medicine for novel treatment and prevention strategies as called for in NIA AD+ADRD Research Implementation Milestone 1. For nearly 10 years, HABS-HD has built a network of community ties and relationships using a community-based approach to recruitment. This approach, which emphasized outreach, engagement, and collaboration between the research team and key stakeholders in the community, led to the successful recruitment of 2,000 participants (n=1,000 NHW, 1,000 MA) aged 50 and older and longitudinal follow-ups are underway. Based on UNTHSC Institutional funding, the cohort has expanded to include 1,000 AAs with recruitment to be completed prior to initiation of this U19. As part of the proposed U19, the primary goal of the Core E is to further increase awareness and engagement of diverse communities into research and to provide the outreach infrastructure to comprehensively understand the development and progression of AD and ADRDs across the lifecourse. To address this goal, Core E will address the following Specific Aims: Aim 1: Extend the recruitment of the HABS-HD cohort to ages 30-49 (n=500 per racial/ethnic group), retain existing participants, and recruit new participants to counteract attrition. Aim 2: Generate and disseminate educational materials regarding the importance of brain aging over the lifecourse and the importance of research in diverse communities. Aim 3: In collaboration with all Cores and Projects, continue to monitor and ensure that all HABS-HD activities are conducted in alignment with the NIA Health Disparities Research Framework.

HABS-HD 差异和外展核心（核心 E）- 摘要 国家阿尔茨海默氏症项目法案 (NAPA) 的主要目标之一是“改善少数民族的治疗结果” 然而，在理解差异的原因方面存在巨大差距。 少数族裔和种族中阿尔茨海默病 (AD) 和 AD 相关疾病 (ADRD) 的发病率增加 人口存在的主要原因是少数群体在老龄化研究中代表性不足。 参与和外展被认为是招募不同人群的最成功的策略之一 达拉斯福斯沃斯​​ (DFW) 大都市，健康与衰老大脑研究中心的所在地。 差异（HABS-HD），目前反映了未来美国的种族/族裔人口和理想的位置 同时研究非裔美国人 (AA)、墨西哥裔美国人 (MA；63% 的人 HABS-HD 是第一个大规模、以社区为基础的计划。 项目将同时研究 AT(N) 定义的每个生物标志物，与 NIA Health 保持一致 HABS-HD 的长期目标是建立针对特定人群的知情信息。 NIA AD+ADRD 研究中呼吁的精准医疗新治疗和预防策略 实施里程碑 1. 近 10 年来，HABS-HD 建立了一个社区联系网络， 使用基于社区的招聘方法建立关系这种方法强调外展， 研究团队和社区主要利益相关者之间的参与和合作，导致了 成功招募了 2,000 名 50 岁及以上的参与者（n=1,000 NHW，1,000 MA）并进行纵向研究 在 UNTHSC 机构的资助下，后续行动正在进行中，该群体已扩大到 1,000 人。 AA 的招募工作将在 U19 启动之前完成。 核心 E 的目标是进一步提高不同社区对研究和研究的认识和参与 提供外展基础设施以全面了解 AD 的发展和进展 为了实现这一目标，核心 E 将实现以下具体目标： 目标 1：将 HABS-HD 队列的招募范围扩大到 30-49 岁（每个种族/民族群体 500 人），保留现有的 目标 2：开展和传播教育活动。 关于大脑衰老在生命过程中的重要性以及不同领域研究的重要性的材料 目标 3：与所有核心和项目合作，继续监控并确保所有社区。 HABS-HD 活动是根据 NIA 健康差异研究框架进行的。