HABS-HD - Core B - Neuroimaging & Informatics Core

HABS-HD - 核心 B - 神经影像

• 批准号: 10708866
• 负责人: Sid E O'Bryant
• 金额: $ 185.8万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10708866
• 关键词: Alzheimer' s Disease; Amyloid; Atherosclerosis; Authorization documentation; Biological Markers; Biostatistics Core; Blood Vessels; Brain; Cerebrovascular Circulation; Clinical; Clinical Data; Collaborations; Collection; Communities; Computers; Custom; Data; Data Analyses; Data Collection; Databases; Dementia; Diffusion Magnetic Resonance Imaging; Documentation; Ensure; Environment; Ethnic Population; Generations; Genetic; Goals; Health; Health Sciences; Hemorrhage; Hippocampus; Image; Informatics; Information Systems; Infrastructure; Laboratories; Leadership; Liquid substance; MRI Scans; Magnetic Resonance Imaging; Measures; Methods; Nerve Degeneration; Neuropsychology; Noise; Parkinson Disease; Participant; Patients; Phase; Policies; Population; Positron-Emission Tomography; Process; Protocols documentation; Publications; Qualifying; Quality Control; Research; Research Personnel; Resolution; Risk; Role; Scanning; Schedule; Scientist; Services; Site; Slice; Support System; Texas; Translational Research; Universities; White Matter Hyperintensity; Work; aging brain; authority; data acquisition; data analysis pipeline; data dissemination; data management; electronic data; electronic data capture system; experience; health application; health disparity; imaging facilities; imaging modality; improved; multi-site trial; multimodality; neuroimaging; open data; programs; progression marker; racial population; tau Proteins; tool; user-friendly; web site

HABS-HD Neuroimaging & Informatics Core (Core B) Abstract The Neuroimaging & Informatics Core (Core B) is responsible for all neuroimaging acquisition protocols, storage protocols, QA/QC protocols, processing pipelines, and long-term storage of raw scans for the Health and Aging Brain Study- Health Disparities (HABS-HD) U19. The overall objective of Core B is to provide high quality imaging and summary data for Projects 1, 2, and 3 and for all U19 investigators. Core B is led by Dr. Arthur Toga (USC/LONI) and Co-Led by Dr. Meredith Braskie (USC/LONI/IGC). Images obtained as part of HABS-HD are stored and managed within the Laboratory of Neuro Imaging (LONI). At initiation of the HABS- HD U19, approximately 5,000 MRI scans and 6,000 PET scans will have been collected, stored and processed. HABS-HD magnetic resonance imaging (MRI) and amyloid positron emission tomography (PET) acquisition largely aligns to standard ADNI3 protocols. Selected imaging modalities will be processed by Core B and summary data will be uploaded to the HABS-HD database at 6-month intervals. All raw scans will also be available. Core B will provide the amyloid (A), tau (T), neurodegeneration (N), for the AT(N) framework that will be leveraged by Projects 1, 2 and 3, and will also provide summary vascular imaging data to be used by Project 2. All neuroimaging for the HABS-HD program occurs at the University of North Texas Health Science Center Institute for Translational Research (UNTHSC ITR) Imaging Center using the same MRI and PET scanners. Core strengths include decades of experience developing and managing multisite, large data projects. Under the leadership of Drs. Toga and Braskie and using the infrastructure of the USC Institute for Neuroimaging and Informatics (INI), LONI and ATRI, we will provide multi-site data management and dissemination of imaging and clinical data in a manner consistent with systems supporting the Alzheimer Disease Neuroimaging Initiative (ADNI), Global Alzheimer’s Association Interactive Network (GAAIN), Parkinson Progression Marker Initiative (PPMI), and others. All Core B activities will support the U19 scientific goals and the broader national AD and dementia research community. This first-ever comprehensive multimodal study of AD risk using the AT(N) framework within the three largest racial/ethnic groups in the U.S. (75% of the population) requires robust informatics, data management, and harmonization. Core B Aims are as follows: Aim 1: To create an imaging and informatics data management framework for all U19 Projects. Aim 2: To ensure high quality control of all neuroimaging data. Aim 3: To deliver a harmonized analysis workflow for each imaging modality that can accommodate any computational environment.

HABS-HD神经影像学和信息学核心（核心B）摘要 神经影像学和信息学核心（核心B）负责所有神经影像学协议， 存储协议，QA/QC协议，处理管道和生理扫描的长期存储 和衰老的大脑研究 - 健康差异（HABS-HD）U19。核心B的总体目标是提供高 项目1、2和3的质量成像和摘要数据以及所有U19调查人员。核心B由博士领导。 Arthur Toga（USC/LONI），由Meredith Braskie博士（USC/LONI/IGC）共同主持。作为作为一部分获得的图像 HABS-HD在Neuro Imaging（LONI）的实验室中存储和管理。在哈布斯的主动性 HD U19，将收集，存储和处理大约5,000次MRI扫描和6,000次PET扫描。 HABS-HD磁共振成像（MRI）和淀粉样正电子发射断层扫描（PET）采集 在很大程度上与标准ADNI3协议保持一致。选定的成像方式将由核心B和 摘要数据将以6个月的间隔上传到HABS-HD数据库。所有原始扫描也将是 可用的。核心B将为AT（n）框架提供淀粉样蛋白（a），tau（t），神经变性（n） 项目1、2和3将利用，并将提供摘要的血管成像数据 项目2。HABS-HD计划的所有神经影像都发生在北德克萨斯大学健康科学 中心翻译研究所（UNTHSC ITR）成像中心使用相同的MRI和PET 扫描仪。核心优势包括数十年的发展和管理多站点大数据的经验 项目。在博士的领导下。 Toga和Braskie以及使用USC研究所的基础设施 神经影像学和信息学（INI），LONI和ATRI，我们将提供多站点数据管理和 以与支持阿尔茨海默氏症的系统一致的方式传播成像和临床数据 疾病神经影像倡议（ADNI），全球阿尔茨海默氏症协会互动网络（GAAIN）， 帕金森进步标记倡议（PPMI）等。所有核心B活动都将支持U19科学 目标以及更广泛的国家广告和痴呆症研究界。这个有史以来第一个全面的多模式 在美国三个最大的种族/种族中使用AT（N）框架的AT（N）框架研究（75％） 人口）需要强大的信息，数据管理和协调。核心B的目标如下：目标 1：为所有U19项目创建成像和信息数据管理框架。目标2：确保 所有神经影像数据的高质量控制。目标3：为每个成像提供一个统一的分析工作流程 可以适应任何计算环境的方式。