HABS-HD - Core A - Admin Core

HABS-HD - 核心 A - 管理核心

• 批准号: 10493845
• 负责人: Sid E O'Bryant
• 金额: $ 115.51万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10493845
• 关键词: Address; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Amyloid; Biological Markers; Biometry; Biostatistics Core; Clinic; Clinical; Collaborations; Collection; Communication; Communities; Complement; Data; Data Collection; Decision Making; Development; Effectiveness; Ensure; Ethnic group; Goals; Health; Health Disparities Research; Informatics; Institution; Institutional Review Boards; Leadership; Literature; Methods; Mission; Monitor; Not Hispanic or Latino; Participant; Patient Recruitments; Pharmaceutical Preparations; Policies; Population Heterogeneity; Positron-Emission Tomography; Principal Investigator; Procedures; Protocols documentation; Publications; Quality Control; Recommendation; Reporting; Research; Research Personnel; Resources; Science; Series; Structure; System; Time; Tracer; Work; aging brain; base; data access; data dissemination; data portal; data quality; health disparity; health goals; interest; meetings; neuroimaging; organizational structure; outreach; programs; racial and ethnic; tau Proteins

HABS-HD ADMINISTRATIVE CORE (CORE A) - ABSTRACT Core A has been providing leadership and management to the Health & Aging Brain Study – Health Disparities (HABS-HD) study since inception and has ensured all proposed metrics have been met. Core A will continue to support the overall mission of HABS-HD to achieve the long-term goal of establishing a comprehensive understanding of AT(N) defined biomarkers across diverse populations, thereby addressing one of the most critical gaps in the existing literature as well as multiple components of NIA AD+ADRD Research Implementation Milestone 1. Given the recent approval of an anti-amyloid drug, this work is now more important than ever. The overall goal of the HABS-HD Core A is to continue to provide critical organizational oversight in order to accomplish the scientific goals and to serve as the nexus of leadership for the U19 as a whole and each of its interlocking Cores, Projects, and committees. Core A will coordinate the integrated components and activities of HABS-HD to accomplish the following aims: Aim 1: Provide organizational support and structure to the Multi Principal Investigator (MPI) team, Cores, Projects and committees. Aim 2: Continue to provide structured communication activities for the HABS-HD team. Organize and make decisions on recommendations from the Core and Project Leads and committees as well as execute those decisions. Organize and plan the annual HABS-HD meetings. Organize and be responsible for any/all NIA communications and reporting. Aim 3: Work with the Cores, Projects, Executive Committee (EC) and Steering Committee (SC) to: (a) continue to refine and monitor structure for ensuring progress towards goals for all aspects of HABS-HD including participant recruitment/retention, protocol refinement and development, participant assessments, biospecimen collection, storage and dissemination of data and biospecimens, (b) ensure timely completion of the HABS-HD Projects and (c) monitor all IRB and FDA IND (PET tau tracer) aspects of the study. Aim 4: Working with all Cores, ensure the refinement/development and public availability of all HABS-HD policies and procedures for data collection, data quality control (QC), resource (data and biospecimens) sharing and dissemination, publications, and potential new research directions. Aim 5: Work with the Neuroimaging & Informatics Core, Biostatistics Core and data teams, to generate, refine and implement a series of policies and committees to support access to data through the LONI data portal. Promote and encourage utilization of these unique and valuable data. Monitor data utilization and ensure that systems for data access are effective and efficient. Work with the Development Core to ensure access of HABS-HD data to junior investigators interested in health disparities research in AD. Aim 6: Work with all Core and Project Leads/Co-Leads to ensure maximum collaboration within the HABS-HD team. Aim 7: Work with all Cores to ensure maximum overlap with other ongoing, large-scale AD+ADRD programs to ensure cross-study comparisons and facilitate access to HABS-HD data for these other initiatives.

HABS -HD管理核心（核心A） - 摘要 核心A一直为健康与衰老的大脑研究提供领导和管理 - 健康差异 （HABS-HD）自成立以来的研究，并确保满足所有拟议的指标。核心A将继续 支持HABS-HD的整体使命，以实现建立全面的长期目标 了解AT（n）在潜水员种群中定义的生物标志物，从而解决了最多的生物标志物之一 现有文献以及NIA AD+ADRD研究的多个组成部分的关键差距 实施里程碑1。鉴于最近批准了一种抗淀粉样药，这项工作现在更加 比以往任何时候都重要。 HABS-HD核心A的总体目标是继续提供关键的组织 监督以实现科学目标并作为U19领导力的联系 整个互锁的核心，项目和委员会。核心A将协调集成的 HABS-HD的组件和活动以实现以下目的：目标1：提供组织 多主要研究员（MPI）团队，核心，项目和委员会的支持和结构。目标2： 继续为HABS-HD团队提供结构化的沟通活动。组织并做出决定 根据核心和项目领导和委员会的建议以及执行这些决定。 组织和计划年度HABS-HD会议。组织并负责任何/所有NIA 通讯和报告。目标3：与核心，项目，执行委员会（EC）和转向一起工作 委员会（SC）至：（a）继续完善并监控结构，以确保所有人的目标进步 HABS-HD的各个方面，包括参与招聘/保留，协议改进和开发， 参与者的评估，生物循环收集，数据和生物环境的存储和传播，（b） 确保及时完成HABS-HD项目，（c）监视所有IRB和FDA IND（PET TAU TRACER） 研究的各个方面。目标4：与所有核心合作，确保改进/开发和公众可用性 在所有HABS-HD策略和数据收集的程序中，数据质量控制（QC），资源（数据和数据） 生物测量）共享和传播，出版物和潜在的新研究指示。目标5：工作 具有神经影像学和信息学核心，生物统计学核心和数据团队，以生成，完善和 实施一系列政策和委员会，通过LONI数据门户支持访问数据。 促进和鼓励利用这些独特而有价值的数据。监视数据利用，并确保 用于数据访问的系统有效而有效。与开发核心合作以确保访问 HABS-HD数据向对AD健康差异研究感兴趣的初级研究人员。目标6：与所有核心一起工作 项目领导/共同领导者确保在HABS-HD团队内最大程度地合作。目标7：与所有人一起工作 确保与其他正在进行的大型AD+ADRD程序的最大重叠的核心，以确保跨研究 对这些计划进行比较并促进访问HABS-HD数据。